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Nicolas Perrot
Nicolas Perrot
McMaster University
Verified email at crlb-gmel.ca
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Ideal cardiovascular health influences cardiovascular disease risk associated with high lipoprotein (a) levels and genotype: the EPIC-Norfolk prospective population study
N Perrot, R Verbeek, M Sandhu, SM Boekholdt, GK Hovingh, ...
Atherosclerosis 256, 47-52, 2017
922017
Electronic health record-based genome-wide meta-analysis provides insights on the genetic architecture of non-alcoholic fatty liver disease
N Ghodsian, E Abner, CA Emdin, E Gobeil, N Taba, ME Haas, N Perrot, ...
Cell Reports Medicine 2 (11), 2021
852021
Genetic and In Vitro Inhibition of PCSK9 and Calcific Aortic Valve Stenosis
N Perrot, V Valerio, D Moschetta, SM Boekholdt, C Dina, HY Chen, ...
Basic to Translational Science 5 (7), 649-661, 2020
592020
Elevated lipoprotein (a) and risk of atrial fibrillation: an observational and Mendelian randomization study
P Mohammadi-Shemirani, M Chong, S Narula, N Perrot, D Conen, ...
Journal of the American College of Cardiology 79 (16), 1579-1590, 2022
542022
Genetic variation in LPA, calcific aortic valve stenosis in patients undergoing cardiac surgery, and familial risk of aortic valve microcalcification
N Perrot, S Thériault, C Dina, HY Chen, SM Boekholdt, S Rigade, ...
JAMA cardiology 4 (7), 620-627, 2019
492019
Lipoprotein (a), oxidized phospholipids, and aortic valve microcalcification assessed by 18F-sodium fluoride positron emission tomography and computed tomography
AA Després, N Perrot, A Poulin, L Tastet, M Shen, HY Chen, R Bourgeois, ...
CJC open 1 (3), 131-140, 2019
462019
GWAS and ExWAS of blood mitochondrial DNA copy number identifies 71 loci and highlights a potential causal role in dementia
M Chong, P Mohammadi-Shemirani, N Perrot, W Nelson, R Morton, ...
Elife 11, e70382, 2022
442022
Association of long-term exposure to elevated lipoprotein (a) levels with parental life span, chronic disease–free survival, and mortality risk: a Mendelian randomization analysis
BJ Arsenault, W Pelletier, Y Kaiser, N Perrot, C Couture, KT Khaw, ...
JAMA network open 3 (2), e200129-e200129, 2020
352020
Life's simple 7 and calcific aortic valve stenosis incidence in apparently healthy men and women
N Perrot, SM Boekholdt, P Mathieu, NJ Wareham, KT Khaw, BJ Arsenault
International journal of cardiology 269, 226-228, 2018
332018
Polygenic risk score for coronary artery disease improves the prediction of early-onset myocardial infarction and mortality in men
HD Manikpurage, A Eslami, N Perrot, Z Li, C Couture, P Mathieu, Y Bossé, ...
Circulation: Genomic and Precision Medicine 14 (6), e003452, 2021
252021
Does lifestyle contribute to disease severity in patients with inherited lipid disorders?
BJ Arsenault, N Perrot, P Couture
Current Opinion in Lipidology 28 (2), 177-185, 2017
202017
Lipoprotein proteomics and aortic valve transcriptomics identify biological pathways linking lipoprotein (a) levels to aortic stenosis
R Bourgeois, J Bourgault, AA Despres, N Perrot, J Guertin, A Girard, ...
Metabolites 11 (7), 459, 2021
182021
Interaction of autotaxin with lipoprotein (a) in patients with calcific aortic valve stenosis
R Bourgeois, R Devillers, N Perrot, AA Després, MC Boulanger, ...
Basic to Translational Science 5 (9), 888-897, 2020
172020
Lipoprotein-associated phospholipase A2 activity, genetics and calcific aortic valve stenosis in humans
N Perrot, S Thériault, S Rigade, HY Chen, C Dina, A Martinsson, ...
Heart 106 (18), 1407-1412, 2020
152020
Therapeutic agents targeting cardiometabolic risk for preventing and treating atherosclerotic cardiovascular diseases
BJ Arsenault, N Perrot, R Puri
Clinical Pharmacology & Therapeutics 104 (2), 257-268, 2018
142018
A comparative analysis of the lipoprotein (a) and low-density lipoprotein proteomic profiles combining mass spectrometry and Mendelian randomization
R Bourgeois, A Girard, N Perrot, J Guertin, PL Mitchell, C Couture, C Gotti, ...
CJC open 3 (4), 450-459, 2021
132021
Sex-Specific Associations of Genetically Predicted Circulating Lp(a) (Lipoprotein(a)) and Hepatic LPA Gene Expression Levels With Cardiovascular Outcomes …
J Guertin, Y Kaiser, H Manikpurage, N Perrot, R Bourgeois, C Couture, ...
Circulation: Genomic and Precision Medicine 14 (4), e003271, 2021
112021
A trans‐omic Mendelian randomization study of parental lifespan uncovers novel aging biology and therapeutic candidates for chronic diseases
N Perrot, W Pelletier, J Bourgault, C Couture, Z Li, PL Mitchell, ...
Aging Cell 20 (11), e13497, 2021
92021
Circulating galectin-3 levels are not associated with nonalcoholic fatty liver disease: A mendelian randomization study
M Tremblay, N Perrot, N Ghodsian, É Gobeil, C Couture, PL Mitchell, ...
The Journal of Clinical Endocrinology & Metabolism 106 (8), e3178-e3184, 2021
72021
A versatile, fast and unbiased method for estimation of gene-by-environment interaction effects on biobank-scale datasets
M Di Scipio, M Khan, S Mao, M Chong, C Judge, N Pathan, N Perrot, ...
Nature Communications 14 (1), 5196, 2023
62023
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