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Heather Lau
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α-Synuclein strains target distinct brain regions and cell types
A Lau, RWL So, HHC Lau, JC Sang, A Ruiz-Riquelme, SC Fleck, E Stuart, ...
Nature neuroscience 23 (1), 21-31, 2020
2412020
Prion-like propagation of β-amyloid aggregates in the absence of APP overexpression
A Ruiz-Riquelme, HHC Lau, E Stuart, AN Goczi, Z Wang, G Schmitt-Ulms, ...
Acta Neuropathologica Communications 6, 1-16, 2018
642018
Alpha-synuclein seeding shows a wide heterogeneity in multiple system atrophy
I Martinez-Valbuena, NP Visanji, A Kim, HHC Lau, RWL So, ...
Translational Neurodegeneration 11 (1), 7, 2022
482022
The existence of Aβ strains and their potential for driving phenotypic heterogeneity in Alzheimer’s disease
HHC Lau, M Ingelsson, JC Watts
Acta Neuropathologica 142 (1), 17-39, 2021
422021
Application of CRISPR genetic screens to investigate neurological diseases
RWL So, SW Chung, HHC Lau, JJ Watts, E Gaudette, ZAM Al-Azzawi, ...
Molecular Neurodegeneration 14, 1-16, 2019
322019
Aβ43 aggregates exhibit enhanced prion-like seeding activity in mice
A Ruiz-Riquelme, A Mao, MM Barghash, HHC Lau, E Stuart, GG Kovacs, ...
Acta neuropathologica communications 9 (1), 83, 2021
192021
Mdm2 and MdmX RING domains play distinct roles in the regulation of p53 responses: a comparative study of Mdm2 and MdmX RING domains in U2OS cells
O Egorova, HHC Lau, K McGraphery, Y Sheng
International Journal of Molecular Sciences 21 (4), 1309, 2020
72020
Discriminating strains of self-propagating protein aggregates using a conformational stability assay
HHC Lau, A Lau, JC Watts
Peptide Self-Assembly, 339-354, 2018
62018
The G51D SNCA mutation generates a slowly progressive α-synuclein strain in early-onset Parkinson’s disease
HHC Lau, I Martinez-Valbuena, RWL So, S Mehra, NRG Silver, A Mao, ...
Acta neuropathologica communications 11 (1), 72, 2023
32023
Strains of self-propagating protein aggregates in human neurodegenerative disease
HHC Lau
University of Toronto (Canada), 2022
12022
A novel approach to evaluate alpha-synuclein seeding shows a wide heterogeneity in multiple system atrophy
I Martinez-Valbuena, NP Visanji, A Kim, HHC Lau, RWL So, ...
Biorxiv, 2021.08. 10.455800, 2021
12021
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Articles 1–11