α-Synuclein strains target distinct brain regions and cell types A Lau, RWL So, HHC Lau, JC Sang, A Ruiz-Riquelme, SC Fleck, E Stuart, ... Nature neuroscience 23 (1), 21-31, 2020 | 241 | 2020 |
Prion-like propagation of β-amyloid aggregates in the absence of APP overexpression A Ruiz-Riquelme, HHC Lau, E Stuart, AN Goczi, Z Wang, G Schmitt-Ulms, ... Acta Neuropathologica Communications 6, 1-16, 2018 | 64 | 2018 |
Alpha-synuclein seeding shows a wide heterogeneity in multiple system atrophy I Martinez-Valbuena, NP Visanji, A Kim, HHC Lau, RWL So, ... Translational Neurodegeneration 11 (1), 7, 2022 | 48 | 2022 |
The existence of Aβ strains and their potential for driving phenotypic heterogeneity in Alzheimer’s disease HHC Lau, M Ingelsson, JC Watts Acta Neuropathologica 142 (1), 17-39, 2021 | 42 | 2021 |
Application of CRISPR genetic screens to investigate neurological diseases RWL So, SW Chung, HHC Lau, JJ Watts, E Gaudette, ZAM Al-Azzawi, ... Molecular Neurodegeneration 14, 1-16, 2019 | 32 | 2019 |
Aβ43 aggregates exhibit enhanced prion-like seeding activity in mice A Ruiz-Riquelme, A Mao, MM Barghash, HHC Lau, E Stuart, GG Kovacs, ... Acta neuropathologica communications 9 (1), 83, 2021 | 19 | 2021 |
Mdm2 and MdmX RING domains play distinct roles in the regulation of p53 responses: a comparative study of Mdm2 and MdmX RING domains in U2OS cells O Egorova, HHC Lau, K McGraphery, Y Sheng International Journal of Molecular Sciences 21 (4), 1309, 2020 | 7 | 2020 |
Discriminating strains of self-propagating protein aggregates using a conformational stability assay HHC Lau, A Lau, JC Watts Peptide Self-Assembly, 339-354, 2018 | 6 | 2018 |
The G51D SNCA mutation generates a slowly progressive α-synuclein strain in early-onset Parkinson’s disease HHC Lau, I Martinez-Valbuena, RWL So, S Mehra, NRG Silver, A Mao, ... Acta neuropathologica communications 11 (1), 72, 2023 | 3 | 2023 |
Strains of self-propagating protein aggregates in human neurodegenerative disease HHC Lau University of Toronto (Canada), 2022 | 1 | 2022 |
A novel approach to evaluate alpha-synuclein seeding shows a wide heterogeneity in multiple system atrophy I Martinez-Valbuena, NP Visanji, A Kim, HHC Lau, RWL So, ... Biorxiv, 2021.08. 10.455800, 2021 | 1 | 2021 |