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Ulrich Bierbach
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Design, Synthesis, and biological activity of a novel non-cisplatin-type platinum− acridine pharmacophore
ET Martins, H Baruah, J Kramarczyk, G Saluta, CS Day, GL Kucera, ...
Journal of medicinal chemistry 44 (25), 4492-4496, 2001
1642001
Synthesis, Structure, Biological Activity, and DNA Binding of Platinum(II) Complexes of the Type trans-[PtCl2(NH3)L] (L = Planar Nitrogen Base). Effect of L and …
U Bierbach, Y Qu, TW Hambley, J Peroutka, HL Nguyen, M Doedee, ...
Inorganic Chemistry 38 (15), 3535-3542, 1999
1521999
Platinum-intercalator conjugates: from DNA-targeted cisplatin derivatives to adenine binding complexes as potential modulators of gene regulation
H Baruah, CG Barry, U Bierbach
Current topics in medicinal chemistry 4 (15), 1537-1549, 2004
1362004
A non-cross-linking platinum− acridine agent with potent activity in non-small-cell lung cancer
Z Ma, JR Choudhury, MW Wright, CS Day, G Saluta, GL Kucera, ...
Journal of medicinal chemistry 51 (23), 7574-7580, 2008
1282008
DNA interactions of antitumor trans‐[PtCl2(NH3)(quinoline)]
A Žákovská, O Nováková, Z Balcarová, U Bierbach, N Farrell, V Brabec
European journal of biochemistry 254 (3), 547-557, 1998
1271998
Zirconium tetraazamacrocycle complexes display extraordinary stability and provide a new strategy for zirconium-89-based radiopharmaceutical development
DN Pandya, N Bhatt, H Yuan, CS Day, BM Ehrmann, M Wright, ...
Chemical Science 8 (3), 2309-2314, 2017
1222017
Modification of platinum (II) antitumor complexes with sulfur ligands. 1. Synthesis, structure, and spectroscopic properties of cationic complexes of the types [PtCl (diamine …
U Bierbach, TW Hambley, N Farrell
Inorganic Chemistry 37 (4), 708-716, 1998
1161998
Mechanism of action of non-cisplatin type DNA-targeted platinum anticancer agents: DNA interactions of novel acridinylthioureas and their platinum conjugates
H Baruah, CL Rector, SM Monnier, U Bierbach
Biochemical pharmacology 64 (2), 191-200, 2002
1092002
Solution Structural Study of a DNA Duplex Containing the Guanine-N7 Adduct Formed by a Cytotoxic Platinum−Acridine Hybrid Agent,
H Baruah, MW Wright, U Bierbach
Biochemistry 44 (16), 6059-6070, 2005
942005
DNA metalating–intercalating hybrid agents for the treatment of chemoresistant cancers
J Suryadi, U Bierbach
Chemistry–A European Journal 18 (41), 12926-12934, 2012
892012
Using Fluorescent Post-Labeling to Probe the Subcellular Localization of DNA-Targeted Platinum
S Ding, X Qiao, J Suryadi, GS Marrs, GL Kucera, U Bierbach
Angewandte Chemie (International ed. in English) 52 (12), 2013
832013
Unprecedented monofunctional metalation of adenine nucleobase in guanine-and thymine-containing dinucleotide sequences by a cytotoxic platinum− acridine hybrid agent
CG Barry, H Baruah, U Bierbach
Journal of the American Chemical Society 125 (32), 9629-9637, 2003
722003
Unusual intercalation of acridin‐9‐ylthiourea into the 5′‐GA/TC DNA base step from the minor groove: implications for the covalent DNA adduct profile of a novel platinum …
H Baruah, U Bierbach
Nucleic acids research 31 (14), 4138-4146, 2003
692003
Modulation of nucleotide binding of trans platinum (II) complexes by planar ligands. A combined proton NMR and molecular mechanics study
U Bierbach, N Farrell
Inorganic chemistry 36 (17), 3657-3665, 1997
661997
Duplex-promoted platination of adenine-N3 in the minor groove of DNA: challenging a longstanding bioinorganic paradigm
CG Barry, CS Day, U Bierbach
Journal of the American Chemical Society 127 (4), 1160-1169, 2005
642005
Structure–activity relationships in platinum–acridinylthiourea conjugates: effect of the thiourea nonleaving group on drug stability, nucleobase affinity, and in vitro cytotoxicity
MC Ackley, CG Barry, AM Mounce, MC Farmer, BE Springer, CS Day, ...
JBIC Journal of Biological Inorganic Chemistry 9, 453-461, 2004
632004
Inversion of the cis geometry requirement for cytotoxicity in structurally novel platinum (II) complexes containing the bidentate N, O-donor pyridin-2-yl-acetate
U Bierbach, M Sabat, N Farrell
Inorganic Chemistry 39 (9), 1882-1890, 2000
602000
Modification of platinum (II) antitumor complexes with sulfur ligands. 2. Reactivity and nucleotide binding properties of cationic complexes of the types [PtCl (diamine)(L …
U Bierbach, JD Roberts, N Farrell
Inorganic Chemistry 37 (4), 717-723, 1998
591998
The cell’s nucleolus: an emerging target for chemotherapeutic intervention
AJ Pickard, U Bierbach
ChemMedChem 8 (9), 1441-1449, 2013
582013
Synthesis, biological activity, and DNA-damage profile of platinum-threading intercalator conjugates designed to target adenine
R Guddneppanavar, G Saluta, GL Kucera, U Bierbach
Journal of medicinal chemistry 49 (11), 3204-3214, 2006
582006
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