Jeffrey D. Rothstein
Jeffrey D. Rothstein
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A hexanucleotide repeat expansion in C9ORF72 is the cause of chromosome 9p21-linked ALS-FTD
AE Renton, E Majounie, A Waite, J Simón-Sánchez, S Rollinson, ...
Neuron 72 (2), 257-268, 2011
Knockout of glutamate transporters reveals a major role for astroglial transport in excitotoxicity and clearance of glutamate
JD Rothstein, M Dykes-Hoberg, CA Pardo, LA Bristol, L Jin, RW Kuncl, ...
Neuron 16 (3), 675-686, 1996
Identification of a unique TGF-β–dependent molecular and functional signature in microglia
O Butovsky, MP Jedrychowski, CS Moore, R Cialic, AJ Lanser, G Gabriely, ...
Nature neuroscience 17 (1), 131-143, 2014
Localization of neuronal and glial glutamate transporters
JD Rothstein, L Martin, AI Levey, M Dykes-Hoberg, L Jin, D Wu, N Nash, ...
Neuron 13 (3), 713-725, 1994
Selective loss of glial glutamate transporter GLT‐1 in amyotrophic lateral sclerosis
JD Rothstein, M Van Kammen, AI Levey, LJ Martin, RW Kuncl
Annals of Neurology: Official Journal of the American Neurological …, 1995
β-Lactam antibiotics offer neuroprotection by increasing glutamate transporter expression
JD Rothstein, S Patel, MR Regan, C Haenggeli, YH Huang, DE Bergles, ...
Nature 433 (7021), 73-77, 2005
From Charcot to Lou Gehrig: deciphering selective motor neuron death in ALS
DW Cleveland, JD Rothstein
Nature reviews neuroscience 2 (11), 806-819, 2001
ALS-linked SOD1 mutant G85R mediates damage to astrocytes and promotes rapidly progressive disease with SOD1-containing inclusions
LI Bruijn, MW Becher, MK Lee, KL Anderson, NA Jenkins, NG Copeland, ...
Neuron 18 (2), 327-338, 1997
Oligodendroglia metabolically support axons and contribute to neurodegeneration
Y Lee, BM Morrison, Y Li, S Lengacher, MH Farah, PN Hoffman, Y Liu, ...
Nature 487 (7408), 443-448, 2012
Decreased glutamate transport by the brain and spinal cord in amyotrophic lateral sclerosis
JD Rothstein, LJ Martin, RW Kuncl
New England Journal of Medicine 326 (22), 1464-1468, 1992
Exome sequencing reveals VCP mutations as a cause of familial ALS
JO Johnson, J Mandrioli, M Benatar, Y Abramzon, VM Van Deerlin, ...
Neuron 68 (5), 857-864, 2010
Retrograde viral delivery of IGF-1 prolongs survival in a mouse ALS model
BK Kaspar, J Lladó, N Sherkat, JD Rothstein, FH Gage
Science 301 (5634), 839-842, 2003
Focal loss of the glutamate transporter EAAT2 in a transgenic rat model of SOD1 mutant-mediated amyotrophic lateral sclerosis (ALS)
DS Howland, J Liu, Y She, B Goad, NJ Maragakis, B Kim, J Erickson, ...
Proceedings of the National Academy of Sciences 99 (3), 1604-1609, 2002
Mechanisms of disease: astrocytes in neurodegenerative disease
NJ Maragakis, JD Rothstein
Nature clinical practice Neurology 2 (12), 679-689, 2006
RNA toxicity from the ALS/FTD C9ORF72 expansion is mitigated by antisense intervention
CJ Donnelly, PW Zhang, JT Pham, AR Haeusler, NA Mistry, S Vidensky, ...
Neuron 80 (2), 415-428, 2013
C9orf72 nucleotide repeat structures initiate molecular cascades of disease
AR Haeusler, CJ Donnelly, G Periz, EAJ Simko, PG Shaw, MS Kim, ...
Nature 507 (7491), 195-200, 2014
The C9orf72 repeat expansion disrupts nucleocytoplasmic transport
K Zhang, CJ Donnelly, AR Haeusler, JC Grima, JB Machamer, ...
Nature 525 (7567), 56-61, 2015
Abnormal excitatory amino acid metabolism in amyotrophic lateral sclerosis
JD Rothstein, G Tsai, RW Kuncl, L Clawson, DR Cornblath, DB Drachman, ...
Annals of neurology 28 (1), 18-25, 1990
Reactive astrocyte nomenclature, definitions, and future directions
C Escartin, E Galea, A Lakatos, JP O’Callaghan, GC Petzold, ...
Nature neuroscience 24 (3), 312-325, 2021
Aberrant RNA processing in a neurodegenerative disease: the cause for absent EAAT2, a glutamate transporter, in amyotrophic lateral sclerosis
CLG Lin, LA Bristol, L Jin, M Dykes-Hoberg, T Crawford, L Clawson, ...
Neuron 20 (3), 589-602, 1998
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