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Jeremy Van Raamsdonk
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Selective striatal neuronal loss in a YAC128 mouse model of Huntington disease
EJ Slow, J van Raamsdonk, D Rogers, SH Coleman, RK Graham, Y Deng, ...
Human molecular genetics 12 (13), 1555-1567, 2003
9352003
Deletion of the Mitochondrial Superoxide Dismutase sod-2 Extends Lifespan in Caenorhabditis elegans
JM Van Raamsdonk, S Hekimi
PLoS genetics 5 (2), e1000361, 2009
6252009
Caspase cleavage of mutant huntingtin precedes neurodegeneration in Huntington's disease
CL Wellington, LM Ellerby, CA Gutekunst, D Rogers, S Warby, ...
Journal of Neuroscience 22 (18), 7862-7872, 2002
4972002
Superoxide dismutase is dispensable for normal animal lifespan
JM Van Raamsdonk, S Hekimi
Proceedings of the National Academy of Sciences 109 (15), 5785-5790, 2012
3792012
Cognitive dysfunction precedes neuropathology and motor abnormalities in the YAC128 mouse model of Huntington's disease
JM Van Raamsdonk, J Pearson, EJ Slow, SM Hossain, BR Leavitt, ...
Journal of Neuroscience 25 (16), 4169-4180, 2005
3752005
Beneficial and detrimental effects of reactive oxygen species on lifespan: a comprehensive review of comparative and experimental studies
HJ Shields, A Traa, JM Van Raamsdonk
Frontiers in cell and developmental biology 9, 628157, 2021
2742021
Wild‐type huntingtin protects neurons from excitotoxicity
BR Leavitt, JM van Raamsdonk, J Shehadeh, H Fernandes, Z Murphy, ...
Journal of neurochemistry 96 (4), 1121-1129, 2006
2562006
Selective degeneration and nuclear localization of mutant huntingtin in the YAC128 mouse model of Huntington disease
JM Van Raamsdonk, Z Murphy, EJ Slow, BR Leavitt, MR Hayden
Human molecular genetics 14 (24), 3823-3835, 2005
2312005
Reactive Oxygen Species and Aging in Caenorhabditis elegans: Causal or Casual Relationship?
JM Van Raamsdonk, S Hekimi
Antioxidants & redox signaling 13 (12), 1911-1953, 2010
2182010
Mitochondrial and cytoplasmic ROS have opposing effects on lifespan
CE Schaar, DJ Dues, KK Spielbauer, E Machiela, JF Cooper, M Senchuk, ...
PLoS genetics 11 (2), e1004972, 2015
2062015
Loss of wild-type huntingtin influences motor dysfunction and survival in the YAC128 mouse model of Huntington disease
JM Van Raamsdonk, J Pearson, DA Rogers, N Bissada, AW Vogl, ...
Human molecular genetics 14 (10), 1379-1392, 2005
2062005
Huntingtin inhibits caspase‐3 activation
Y Zhang, BR Leavitt, JM van Raamsdonk, I Dragatsis, D Goldowitz, ...
The EMBO journal 25 (24), 5896-5906, 2006
1582006
Mitochondrial pyruvate carrier regulates autophagy, inflammation, and neurodegeneration in experimental models of Parkinson’s disease
A Ghosh, T Tyson, S George, EN Hildebrandt, JA Steiner, Z Madaj, ...
Science translational medicine 8 (368), 368ra174-368ra174, 2016
1542016
Modeling Parkinson’s Disease in C. elegans
JF Cooper, JM Van Raamsdonk
Journal of Parkinson's disease 8 (1), 17-32, 2018
1482018
Body weight is modulated by levels of full-length huntingtin
JM Van Raamsdonk, WT Gibson, J Pearson, Z Murphy, G Lu, BR Leavitt, ...
Human molecular genetics 15 (9), 1513-1523, 2006
1422006
FUdR causes a twofold increase in the lifespan of the mitochondrial mutant gas-1
JM Van Raamsdonk, S Hekimi
Mechanisms of ageing and development 132 (10), 519-521, 2011
1302011
Testicular degeneration in Huntington disease
JM Van Raamsdonk, Z Murphy, DM Selva, R Hamidizadeh, J Pearson, ...
Neurobiology of disease 26 (3), 512-520, 2007
1302007
Activation of DAF-16/FOXO by reactive oxygen species contributes to longevity in long-lived mitochondrial mutants in Caenorhabditis elegans
MM Senchuk, DJ Dues, CE Schaar, BK Johnson, ZB Madaj, MJ Bowman, ...
PLoS genetics 14 (3), e1007268, 2018
1292018
Phenotypic abnormalities in the YAC128 mouse model of Huntington disease are penetrant on multiple genetic backgrounds and modulated by strain
JM Van Raamsdonk, M Metzler, E Slow, J Pearson, C Schwab, J Carroll, ...
Neurobiology of disease 26 (1), 189-200, 2007
1282007
Decreased Energy Metabolism Extends Life Span in Caenorhabditis elegans Without Reducing Oxidative Damage
JM Van Raamsdonk, Y Meng, D Camp, W Yang, X Jia, C Bénard, ...
Genetics 185 (2), 559-571, 2010
1232010
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