| A pregnancy physiologically based pharmacokinetic (p‐PBPK) model for disposition of drugs metabolized by CYP1A2, CYP2D6 and CYP3A4 L Gaohua, K Abduljalil, M Jamei, TN Johnson, A Rostami‐Hodjegan British journal of clinical pharmacology 74 (5), 873-885, 2012 | 134 | 2012 |
| Metformin and cimetidine: Physiologically based pharmacokinetic modelling to investigate transporter mediated drug–drug interactions HJ Burt, S Neuhoff, L Almond, L Gaohua, MD Harwood, M Jamei, ... European journal of pharmaceutical sciences 88, 70-82, 2016 | 108 | 2016 |
| Development of a novel maternal-fetal physiologically based pharmacokinetic model I: insights into factors that determine fetal drug exposure through simulations and … Z Zhang, MZ Imperial, GI Patilea-Vrana, J Wedagedera, L Gaohua, ... Drug Metabolism and Disposition 45 (8), 920-938, 2017 | 89 | 2017 |
| Development of a multicompartment permeability‐limited lung PBPK model and its application in predicting pulmonary pharmacokinetics of antituberculosis drugs L Gaohua, J Wedagedera, BG Small, L Almond, K Romero, D Hermann, ... CPT: pharmacometrics & systems pharmacology 4 (10), 605-613, 2015 | 88 | 2015 |
| Crosstalk of physiological pH and chemical pKa under the umbrella of physiologically based pharmacokinetic modeling of drug absorption, distribution, metabolism, excretion, and … L Gaohua, X Miao, L Dou Expert opinion on drug metabolism & toxicology 17 (9), 1103-1124, 2021 | 82 | 2021 |
| Targeted protein degradation in vivo with Proteolysis Targeting Chimeras: Current status and future considerations GF Watt, P Scott-Stevens, L Gaohua Drug Discovery Today: Technologies 31, 69-80, 2019 | 73 | 2019 |
| Accounting for transporters in renal clearance: towards a mechanistic kidney model (Mech KiM) S Neuhoff, L Gaohua, H Burt, M Jamei, L Li, GT Tucker, ... Transporters in drug development: discovery, optimization, clinical study …, 2013 | 73 | 2013 |
| Development of a permeability-limited model of the human brain and cerebrospinal fluid (CSF) to integrate known physiological and biological knowledge: Estimating time varying … L Gaohua, S Neuhoff, TN Johnson, A Rostami-Hodjegan, M Jamei Drug metabolism and pharmacokinetics 31 (3), 224-233, 2016 | 63 | 2016 |
| Applications of linking PBPK and PD models to predict the impact of genotypic variability, formulation differences, differences in target binding capacity and target site drug … M Chetty, RH Rose, K Abduljalil, N Patel, G Lu, T Cain, M Jamei, ... Frontiers in pharmacology 5, 258, 2014 | 60 | 2014 |
| Physiologically-based pharmacokinetic (PBPK) models for assessing the kinetics of xenobiotics during pregnancy: achievements and shortcomings G Lu, K Abduljalil, M Jamei, T N Johnson, H Soltani, A Rostami-Hodjegan Current drug metabolism 13 (6), 695-720, 2012 | 55 | 2012 |
| A mathematical model of brain glucose homeostasis L Gaohua, H Kimura Theoretical Biology and Medical Modelling 6, 1-24, 2009 | 35 | 2009 |
| A mathematical model of intracranial pressure dynamics for brain hypothermia treatment L Gaohua, H Kimura Journal of theoretical biology 238 (4), 882-900, 2006 | 33 | 2006 |
| Predicting nonlinear pharmacokinetics of omeprazole enantiomers and racemic drug using physiologically based pharmacokinetic modeling and simulation: application to predict … F Wu, L Gaohua, P Zhao, M Jamei, SM Huang, ED Bashaw, SC Lee Pharmaceutical research 31, 1919-1929, 2014 | 32 | 2014 |
| An integrated model of thermodynamic–hemodynamic–pharmacokinetic system and its application on decoupling control of intracranial temperature and pressure in brain hypothermia … L Gaohua, T Maekawa, H Kimura Journal of theoretical biology 242 (1), 16-31, 2006 | 17 | 2006 |
| Biothermal model of patient for brain hypothermia treatment H Wakamatsu, L Gaohua IEEJ Transactions on Electronics, Information and Systems 123 (9), 1537-1546, 2003 | 15 | 2003 |
| A mathematical model of respiratory and biothermal dynamics in brain hypothermia treatment L Gaohua, H Kimura IEEE Transactions on Biomedical Engineering 55 (4), 1266-1278, 2008 | 13 | 2008 |
| Biothermal model of patient and automatic control system of brain temperature for brain hypothermia treatment H Wakamatsu, L Gaohua IEEJ Transactions on Electronics, Information and Systems 123 (4), 734-741, 2003 | 12 | 2003 |
| Transporters in Drug Development S Neuhoff, L Gaohua, H Burt, M Jamei, L Li, GT Tucker, ... Springer 7, 155-177, 2013 | 11 | 2013 |
| Adaptive control of brain temperature for brain hypothermia treatment using Stolwijk-Hardy model H Wakamatsu, L Gaohua Artificial Life and Robotics 8, 214-221, 2004 | 9 | 2004 |
| Simulation of propofol anaesthesia for intracranial decompression using brain hypothermia treatment L Gaohua, H Kimura Theoretical Biology and Medical Modelling 4, 1-12, 2007 | 8 | 2007 |
