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Xolani Henry Makhoba
Xolani Henry Makhoba
PhD Biochemistry
Verified email at unisa.ac.za
Title
Cited by
Cited by
Year
Potential impact of the multi-target drug approach in the treatment of some complex diseases
XH Makhoba, C Viegas Jr, RA Mosa, FPD Viegas, OJ Pooe
Drug design, development and therapy, 3235-3249, 2020
1442020
Comparative Characterization of Plasmodium falciparum Hsp70-1 Relative to E. coli DnaK Reveals the Functional Specificity of the Parasite Chaperone
CM Lebepe, PR Matambanadzo, XH Makhoba, I Achilonu, T Zininga, ...
Biomolecules 10 (6), 856, 2020
242020
Use of a chimeric Hsp70 to enhance the quality of recombinant Plasmodium falciparum S-adenosylmethionine decarboxylase protein produced in Escherichia coli
XH Makhoba, A Burger, D Coertzen, T Zininga, LM Birkholtz, A Shonhai
PLoS One 11 (3), e0152626, 2016
202016
Molecular chaperone assisted expression systems: obtaining pure soluble and active recombinant proteins for structural and therapeutic purposes
XH Makhoba, OJ Pooe, MS Mthembu
OMICS International, 2015
102015
Potential impact of the multi-target drug approach in the treatment of some complex diseases. Drug Des Devel Ther 14: 3235–3249
XH Makhoba, C Viegas, RA Mosa, FPD Viegas, OJ Pooe
92020
The capture of host cell’s resources: The role of heat shock proteins and polyamines in SARS-COV-2 (COVID-19) pathway to viral infection
XH Makhoba, S Makumire
Biomolecular Concepts 13 (1), 220-229, 2022
82022
Protein PEGylation: navigating recombinant protein stability, aggregation, and bioactivity
LK Zuma, NL Gasa, XH Makhoba, OJ Pooe
BioMed Research International 2022 (1), 8929715, 2022
82022
Potential impact of the multi-target drug approach in the treatment of some complex diseases. Drug Des Devel Ther. 2020; 14: 3235–49
XH Makhoba, C Viegas Jr, RA Mosa, FP Viegas, OJ Pooe
5
The role of pyridine derivatives on the treatment of some complex diseases: A review
XH Makhoba
Recent Developments in the Synthesis and Applications of Pyridines, 143-158, 2023
32023
A Double Line of Defense: Heat Shock Proteins and Polyamines Act as Contributing Factors to Drug Resistance of some Plasmodium Parasites
XH Makhoba
Plasmodium Species and Drug Resistance, 2021
32021
In silico evaluation of heat shock proteins reveals an interplay with polyamines as a survival strategy for the Plasmodium falciparum
G Sesethu, M Nombalentle, M Yamkela, M Anelisa, S Makumire, ...
INNOSC Theranostics and Pharmacological Sciences 7 (1), 1228, 2023
12023
An Undefined Interaction between Polyamines and Heat Shock Proteins Leads to Cellular Protection in Plasmodium falciparum and Proliferating Cells in Various Organisms
E Makhoba, X.H. Ragno, R. Kaiser, Agostinelli
Molecules 28 (4), 1686, 2023
12023
The development of a molecular chaperone-based system to improve the heterologous production of Plasmodium falciparum AdoMetDC protein in E. coli.
XH Makhoba
12011
In Silico Analysis of SARS-CoV-2 Non-Structural Proteins Reveals an Interaction with the Host’s Heat Shock Proteins That May Contribute to Viral Replications and Development
M Yamkela, Z Sitobo, XH Makhoba
Current Issues in Molecular Biology 45 (12), 10225-10247, 2023
2023
A Comprehensive Review of Some Heat‐Shock Proteins in the Development and Progression of Human Breast Cancer
XH Makhoba, OJ Pooe
Drug and Therapy Development for Triple Negative Breast Cancer, 237-247, 2023
2023
Drug Repurposing: Challenges and Successes in the Treatment of SARS-CoV-2
XH Makhoba
Drug Repurposing-Advances, Scopes and Opportunities in Drug Discovery, 2023
2023
The Computational Analysis of Plasmodium falciparum Heat Shock Proteins Reveals an Interplay with Polyamines
G Sesethu, M Nombalentle, M Yamnkela, M Anelisa, S Makumire, ...
bioRxiv, 2023.05. 11.540332, 2023
2023
Molecular chaperones and human disease
G Chakafana, S Makumire, XH Makhoba
Frontiers in Molecular Biosciences 9, 1068238, 2022
2022
Effects of co-expression of chaperone combinations on production of soluble plasmodial protein PfAdoMetDC in E. coli
XH Makhoba
University of Zululand, 2015
2015
Comparative characterisation of Plasmodium falciparum Hsp70-1 relative to E. coli DnaK reveals functional specificity of the parasite chaperone
CMLPR Matambanadzo, XHM Ikechukwu, AT Zininga, A Shonhai
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Articles 1–20