Potential impact of the multi-target drug approach in the treatment of some complex diseases XH Makhoba, C Viegas Jr, RA Mosa, FPD Viegas, OJ Pooe Drug design, development and therapy, 3235-3249, 2020 | 144 | 2020 |
Comparative Characterization of Plasmodium falciparum Hsp70-1 Relative to E. coli DnaK Reveals the Functional Specificity of the Parasite Chaperone CM Lebepe, PR Matambanadzo, XH Makhoba, I Achilonu, T Zininga, ... Biomolecules 10 (6), 856, 2020 | 24 | 2020 |
Use of a chimeric Hsp70 to enhance the quality of recombinant Plasmodium falciparum S-adenosylmethionine decarboxylase protein produced in Escherichia coli XH Makhoba, A Burger, D Coertzen, T Zininga, LM Birkholtz, A Shonhai PLoS One 11 (3), e0152626, 2016 | 20 | 2016 |
Molecular chaperone assisted expression systems: obtaining pure soluble and active recombinant proteins for structural and therapeutic purposes XH Makhoba, OJ Pooe, MS Mthembu OMICS International, 2015 | 10 | 2015 |
Potential impact of the multi-target drug approach in the treatment of some complex diseases. Drug Des Devel Ther 14: 3235–3249 XH Makhoba, C Viegas, RA Mosa, FPD Viegas, OJ Pooe | 9 | 2020 |
The capture of host cell’s resources: The role of heat shock proteins and polyamines in SARS-COV-2 (COVID-19) pathway to viral infection XH Makhoba, S Makumire Biomolecular Concepts 13 (1), 220-229, 2022 | 8 | 2022 |
Protein PEGylation: navigating recombinant protein stability, aggregation, and bioactivity LK Zuma, NL Gasa, XH Makhoba, OJ Pooe BioMed Research International 2022 (1), 8929715, 2022 | 8 | 2022 |
Potential impact of the multi-target drug approach in the treatment of some complex diseases. Drug Des Devel Ther. 2020; 14: 3235–49 XH Makhoba, C Viegas Jr, RA Mosa, FP Viegas, OJ Pooe | 5 | |
The role of pyridine derivatives on the treatment of some complex diseases: A review XH Makhoba Recent Developments in the Synthesis and Applications of Pyridines, 143-158, 2023 | 3 | 2023 |
A Double Line of Defense: Heat Shock Proteins and Polyamines Act as Contributing Factors to Drug Resistance of some Plasmodium Parasites XH Makhoba Plasmodium Species and Drug Resistance, 2021 | 3 | 2021 |
In silico evaluation of heat shock proteins reveals an interplay with polyamines as a survival strategy for the Plasmodium falciparum G Sesethu, M Nombalentle, M Yamkela, M Anelisa, S Makumire, ... INNOSC Theranostics and Pharmacological Sciences 7 (1), 1228, 2023 | 1 | 2023 |
An Undefined Interaction between Polyamines and Heat Shock Proteins Leads to Cellular Protection in Plasmodium falciparum and Proliferating Cells in Various Organisms E Makhoba, X.H. Ragno, R. Kaiser, Agostinelli Molecules 28 (4), 1686, 2023 | 1 | 2023 |
The development of a molecular chaperone-based system to improve the heterologous production of Plasmodium falciparum AdoMetDC protein in E. coli. XH Makhoba | 1 | 2011 |
In Silico Analysis of SARS-CoV-2 Non-Structural Proteins Reveals an Interaction with the Host’s Heat Shock Proteins That May Contribute to Viral Replications and Development M Yamkela, Z Sitobo, XH Makhoba Current Issues in Molecular Biology 45 (12), 10225-10247, 2023 | | 2023 |
A Comprehensive Review of Some Heat‐Shock Proteins in the Development and Progression of Human Breast Cancer XH Makhoba, OJ Pooe Drug and Therapy Development for Triple Negative Breast Cancer, 237-247, 2023 | | 2023 |
Drug Repurposing: Challenges and Successes in the Treatment of SARS-CoV-2 XH Makhoba Drug Repurposing-Advances, Scopes and Opportunities in Drug Discovery, 2023 | | 2023 |
The Computational Analysis of Plasmodium falciparum Heat Shock Proteins Reveals an Interplay with Polyamines G Sesethu, M Nombalentle, M Yamnkela, M Anelisa, S Makumire, ... bioRxiv, 2023.05. 11.540332, 2023 | | 2023 |
Molecular chaperones and human disease G Chakafana, S Makumire, XH Makhoba Frontiers in Molecular Biosciences 9, 1068238, 2022 | | 2022 |
Effects of co-expression of chaperone combinations on production of soluble plasmodial protein PfAdoMetDC in E. coli XH Makhoba University of Zululand, 2015 | | 2015 |
Comparative characterisation of Plasmodium falciparum Hsp70-1 relative to E. coli DnaK reveals functional specificity of the parasite chaperone CMLPR Matambanadzo, XHM Ikechukwu, AT Zininga, A Shonhai | | |