Similarities and differences between the responses induced in human phagocytes through activation of the medium chain fatty acid receptor GPR84 and the short chain fatty acid … M Sundqvist, K Christenson, A Holdfeldt, M Gabl, J Mårtensson, ... Biochimica et Biophysica Acta (BBA)-Molecular Cell Research 1865 (5), 695-708, 2018 | 45 | 2018 |
The neutrophil response induced by an agonist for free fatty acid receptor 2 (GPR43) is primed by tumor necrosis factor alpha and by receptor uncoupling from the cytoskeleton … L Björkman, J Mårtensson, M Winther, M Gabl, A Holdfeldt, M Uhrbom, ... Molecular and Cellular Biology 36 (20), 2583-2595, 2016 | 43 | 2016 |
Neutrophil signaling that challenges dogmata of G protein-coupled receptor regulated functions C Dahlgren, A Holdfeldt, S Lind, J Mårtensson, M Gabl, L Björkman, ... ACS Pharmacology & Translational Science 3 (2), 203-220, 2020 | 33 | 2020 |
Neutrophil priming that turns natural FFA2R agonists into potent activators of the superoxide generating NADPH-oxidase J Mårtensson, A Holdfeldt, M Sundqvist, M Gabl, TP Kenakin, L Björkman, ... Journal of Leukocyte Biology 104 (6), 1117-1132, 2018 | 29 | 2018 |
Functional selective ATP receptor signaling controlled by the free fatty acid receptor 2 through a novel allosteric modulation mechanism S Lind, A Holdfeldt, J Mårtensson, M Sundqvist, L Björkman, H Forsman, ... The FASEB Journal 33 (6), 6887-6903, 2019 | 26 | 2019 |
Mitocryptides from human mitochondrial DNA–encoded proteins activate neutrophil formyl peptide receptors: receptor preference and signaling properties M Gabl, M Sundqvist, A Holdfeldt, S Lind, J Mårtensson, K Christenson, ... The Journal of Immunology 200 (9), 3269-3282, 2018 | 22 | 2018 |
Neutrophil recruitment to inflamed joints can occur without cellular priming L Björkman, K Christenson, L Davidsson, J Mårtensson, F Amirbeagi, ... Journal of Leukocyte Biology 105 (6), 1123-1130, 2019 | 21 | 2019 |
Interdependent allosteric free fatty acid receptor 2 modulators synergistically induce functional selective activation and desensitization in neutrophils S Lind, A Holdfeldt, J Mårtensson, M Sundqvist, TP Kenakin, L Björkman, ... Biochimica et Biophysica Acta (BBA)-Molecular Cell Research 1867 (6), 118689, 2020 | 20 | 2020 |
The two formyl peptide receptors differently regulate GPR84-mediated neutrophil NADPH oxidase activity J Mårtensson, M Sundqvist, A Manandhar, L Ieremias, L Zhang, T Ulven, ... Journal of Innate Immunity 13 (4), 242-256, 2021 | 15 | 2021 |
G protein coupled pattern recognition receptors expressed in neutrophils: recognition, activation/modulation, signaling and receptor regulated functions C Dahlgren, S Lind, J Mårtensson, L Björkman, Y Wu, M Sundqvist, ... Immunological Reviews 314 (1), 69-92, 2023 | 14 | 2023 |
Identification of Residues Critical for FPR2 Activation by the Cryptic Peptide Mitocryptide-2 Originating from the Mitochondrial DNA–Encoded Cytochrome b S Lind, M Gabl, A Holdfeldt, J Mårtensson, M Sundqvist, K Nishino, ... The Journal of Immunology 202 (9), 2710-2719, 2019 | 13 | 2019 |
GRK2 selectively attenuates the neutrophil NADPH-oxidase response triggered by β-arrestin recruiting GPR84 agonists J Fredriksson, A Holdfeldt, J Mårtensson, L Björkman, TC Møller, ... Biochimica et Biophysica Acta (BBA)-Molecular Cell Research 1869 (7), 119262, 2022 | 9 | 2022 |
Multiple ligand recognition sites in free fatty acid receptor 2 (FFA2R) direct distinct neutrophil activation patterns S Lind, A Holdfeldt, J Mårtensson, KL Granberg, H Forsman, C Dahlgren Biochemical Pharmacology 193, 114762, 2021 | 8 | 2021 |
Function and regulation of GPR84 in human neutrophils H Forsman, C Dahlgren, J Mårtensson, L Björkman, M Sundqvist British Journal of Pharmacology 181 (10), 1536-1549, 2024 | 7 | 2024 |
The ketone body acetoacetate activates human neutrophils through FFAR2 J Mårtensson, L Björkman, S Lind, MB Viklund, L Zhang, S Gutierrez, ... Journal of Leukocyte Biology 113 (6), 577-587, 2023 | 5 | 2023 |
AZ2158 is a more potent formyl peptide receptor 1 inhibitor than the commonly used peptide antagonists in abolishing neutrophil chemotaxis H Forsman, Y Wu, J Mårtensson, L Björkman, KL Granberg, C Dahlgren, ... Biochemical Pharmacology 211, 115529, 2023 | 4 | 2023 |
AB0067 Allosteric receptor modulation of a free fatty acid receptor turns natural agonists into potent activators of the superoxide generating neutrophil nadph-oxidase L Björkman, J Mårtensson, A Holdfeldt, H Forsman, M Gabl, M Sundqvist, ... Annals of the Rheumatic Diseases 77 (Suppl 2), 1232-1232, 2018 | 1 | 2018 |
Interdependent Allosteric FFA2R Modulators Synergistically Induce Functional Selective Activation and Desensitization in Neutrophils S Lind, A Holdfeldt, J Mårtensson, M Sundqvist, TP Kenakin, L Björkman, ... bioRxiv, 809061, 2019 | | 2019 |
Allosteric receptor modulation of FFA2R turns natural agonists into potent activators of the superoxide generating neutrophil NADPH-oxidase J Mårtensson, A Holdfeldt, M Sundqvist, M Gabl, L Björkman, H Forsman, ... bioRxiv, 284935, 2018 | | 2018 |