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Alastair C Keen
Alastair C Keen
Postdoctoral Research Fellow, Monash Institute of Pharmaceutical Sciences, Monash University
Verified email at monash.edu
Title
Cited by
Cited by
Year
Optimization and 13CH3 methionine labeling of a signaling competent neurotensin receptor 1 variant for NMR studies
F Bumbak, AC Keen, NJ Gunn, PR Gooley, RAD Bathgate, DJ Scott
Biochimica et Biophysica Acta (BBA)-Biomembranes 1860 (6), 1372-1383, 2018
392018
Distinct inactive conformations of the dopamine D2 and D3 receptors correspond to different extents of inverse agonism
JR Lane, AM Abramyan, P Adhikari, AC Keen, KH Lee, J Sanchez, ...
Elife 9, e52189, 2020
322020
Molecular determinants of the intrinsic efficacy of the antipsychotic aripiprazole
C Klein Herenbrink, R Verma, HD Lim, A Kopinathan, A Keen, J Shonberg, ...
ACS chemical biology 14 (8), 1780-1792, 2019
242019
Inhibition of the proliferation of human lung fibroblasts by prostacyclin receptor agonists is linked to a sustained cAMP signal in the nucleus
MJ Roberts, LT May, AC Keen, B Liu, T Lam, SJ Charlton, EM Rosethorne, ...
Frontiers in pharmacology 12, 669227, 2021
212021
New phosphosite-specific antibodies to unravel the role of GRK phosphorylation in dopamine D2 receptor regulation and signaling
A Mann, AC Keen, H Mark, P Dasgupta, JA Javitch, M Canals, S Schulz, ...
Scientific Reports 11 (1), 8288, 2021
152021
OZITX, a pertussis toxin-like protein for occluding inhibitory G protein signalling including Gαz
AC Keen, MH Pedersen, L Lemel, DJ Scott, M Canals, DR Littler, ...
Communications Biology 5 (1), 256, 2022
82022
Structure of the metastatic factor P-Rex1 reveals a two-layered autoinhibitory mechanism
YG Chang, CJ Lupton, C Bayly-Jones, AC Keen, L D’Andrea, CM Lucato, ...
Nature Structural & Molecular Biology 29 (8), 767-773, 2022
52022
The application of targeted protein degradation technologies to G protein‐coupled receptors
AC Keen, M Jörg, ML Halls
British Journal of Pharmacology, 2023
32023
Signalling of Adrenoceptors: Canonical Pathways and New Paradigms
C Mastos, X Xu, AC Keen, ML Halls
2024
Kinetic studies of dopamine D2 receptor molecular pharmacology
AC Keen
University of Nottingham, 2021
2021
A new pertussis toxin-like protein complex as a tool for investigation of GPCR-G alpha (i) and G alpha (z) signalling
A Keen, M Pedersen, J Javitch, JR Lane
BRITISH JOURNAL OF PHARMACOLOGY 178 (2), 403-403, 2021
2021
Kinetic investigations into G protein activation and biased agonism at the dopamine D2 receptor
AC Keen, DA Sykes, SJ Charlton, JR Lane
Proceedings for Annual Meeting of The Japanese Pharmacological Society …, 2018
2018
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Articles 1–12