Optimization and 13CH3 methionine labeling of a signaling competent neurotensin receptor 1 variant for NMR studies F Bumbak, AC Keen, NJ Gunn, PR Gooley, RAD Bathgate, DJ Scott Biochimica et Biophysica Acta (BBA)-Biomembranes 1860 (6), 1372-1383, 2018 | 39 | 2018 |
Distinct inactive conformations of the dopamine D2 and D3 receptors correspond to different extents of inverse agonism JR Lane, AM Abramyan, P Adhikari, AC Keen, KH Lee, J Sanchez, ... Elife 9, e52189, 2020 | 32 | 2020 |
Molecular determinants of the intrinsic efficacy of the antipsychotic aripiprazole C Klein Herenbrink, R Verma, HD Lim, A Kopinathan, A Keen, J Shonberg, ... ACS chemical biology 14 (8), 1780-1792, 2019 | 24 | 2019 |
Inhibition of the proliferation of human lung fibroblasts by prostacyclin receptor agonists is linked to a sustained cAMP signal in the nucleus MJ Roberts, LT May, AC Keen, B Liu, T Lam, SJ Charlton, EM Rosethorne, ... Frontiers in pharmacology 12, 669227, 2021 | 21 | 2021 |
New phosphosite-specific antibodies to unravel the role of GRK phosphorylation in dopamine D2 receptor regulation and signaling A Mann, AC Keen, H Mark, P Dasgupta, JA Javitch, M Canals, S Schulz, ... Scientific Reports 11 (1), 8288, 2021 | 15 | 2021 |
OZITX, a pertussis toxin-like protein for occluding inhibitory G protein signalling including Gαz AC Keen, MH Pedersen, L Lemel, DJ Scott, M Canals, DR Littler, ... Communications Biology 5 (1), 256, 2022 | 8 | 2022 |
Structure of the metastatic factor P-Rex1 reveals a two-layered autoinhibitory mechanism YG Chang, CJ Lupton, C Bayly-Jones, AC Keen, L D’Andrea, CM Lucato, ... Nature Structural & Molecular Biology 29 (8), 767-773, 2022 | 5 | 2022 |
The application of targeted protein degradation technologies to G protein‐coupled receptors AC Keen, M Jörg, ML Halls British Journal of Pharmacology, 2023 | 3 | 2023 |
Signalling of Adrenoceptors: Canonical Pathways and New Paradigms C Mastos, X Xu, AC Keen, ML Halls | | 2024 |
Kinetic studies of dopamine D2 receptor molecular pharmacology AC Keen University of Nottingham, 2021 | | 2021 |
A new pertussis toxin-like protein complex as a tool for investigation of GPCR-G alpha (i) and G alpha (z) signalling A Keen, M Pedersen, J Javitch, JR Lane BRITISH JOURNAL OF PHARMACOLOGY 178 (2), 403-403, 2021 | | 2021 |
Kinetic investigations into G protein activation and biased agonism at the dopamine D2 receptor AC Keen, DA Sykes, SJ Charlton, JR Lane Proceedings for Annual Meeting of The Japanese Pharmacological Society …, 2018 | | 2018 |