Exploiting the dynamics of the EPR effect and strategies to improve the therapeutic effects of nanomedicines by using EPR effect enhancers J Fang, W Islam, H Maeda Advanced drug delivery reviews 157, 142-160, 2020 | 476 | 2020 |
Augmentation of the enhanced permeability and retention effect with nitric oxide–generating agents improves the therapeutic effects of nanomedicines W Islam, J Fang, T Imamura, T Etrych, V Subr, K Ulbrich, H Maeda Molecular cancer therapeutics 17 (12), 2643-2653, 2018 | 97 | 2018 |
Enhanced cellular polysulfides negatively regulate TLR4 signaling and mitigate lethal endotoxin shock T Zhang, K Ono, H Tsutsuki, H Ihara, W Islam, T Akaike, T Sawa Cell Chemical Biology 26 (5), 686-698. e4, 2019 | 76 | 2019 |
Augmentation of EPR effect and efficacy of anticancer nanomedicine by carbon monoxide generating agents J Fang, R Islam, W Islam, H Yin, V Subr, T Etrych, K Ulbrich, H Maeda Pharmaceutics 11 (7), 343, 2019 | 57 | 2019 |
Combined targeting of STAT3 and STAT5: a novel approach to overcome drug resistance in chronic myeloid leukemia KV Gleixner, M Schneeweiss, G Eisenwort, D Berger, H Herrmann, K Blatt, ... Haematologica 102 (9), 1519, 2017 | 43 | 2017 |
N-(2-hydroxypropyl) methacrylamide polymer conjugated pyropheophorbide-a, a promising tumor-targeted theranostic probe for photodynamic therapy and imaging J Fang, V Šubr, W Islam, S Hackbarth, R Islam, T Etrych, K Ulbrich, ... European Journal of Pharmaceutics and Biopharmaceutics 130, 165-176, 2018 | 35 | 2018 |
ATP exposure stimulates glutathione efflux as a necessary switch for NLRP3 inflammasome activation T Zhang, H Tsutsuki, W Islam, K Ono, K Takeda, T Akaike, T Sawa Redox biology 41, 101930, 2021 | 28 | 2021 |
Phosphorylcholine-Grafted Molecular Bottlebrush–Doxorubicin Conjugates: High Structural Stability, Long Circulation in Blood, and Efficient Anticancer Activity S Takano, W Islam, K Nakazawa, H Maeda, K Sakurai, S Fujii Biomacromolecules 22 (3), 1186-1196, 2020 | 25 | 2020 |
Polymer-conjugated glucosamine complexed with boric acid shows tumor-selective accumulation and simultaneous inhibition of glycolysis W Islam, Y Matsumoto, J Fang, A Harada, T Niidome, K Ono, H Tsutsuki, ... Biomaterials 269, 120631, 2021 | 24 | 2021 |
Singlet oxygen phosphorescence detection in vivo identifies PDT-induced anoxia in solid tumors S Hackbarth, W Islam, J Fang, V Subr, B Röder, T Etrych, H Maeda Photochemical & Photobiological Sciences 18, 1304-1314, 2019 | 20 | 2019 |
Overcoming barriers for tumor-targeted drug delivery: The power of macromolecular anticancer drugs with the EPR effect and the modulation of vascular physiology H Maeda, W Islam Polymer-Protein Conjugates, 41-58, 2020 | 18 | 2020 |
EPR-effect enhancers strongly potentiate tumor-targeted delivery of nanomedicines to advanced cancers: Further extension to enhancement of the therapeutic effect W Islam, S Kimura, R Islam, A Harada, K Ono, J Fang, T Niidome, T Sawa, ... Journal of Personalized Medicine 11 (6), 487, 2021 | 17 | 2021 |
Enhanced permeability and retention effect as a ubiquitous and epoch-making phenomenon for the selective drug targeting of solid tumors W Islam, T Niidome, T Sawa Journal of Personalized Medicine 12 (12), 1964, 2022 | 16 | 2022 |
HPMA copolymer conjugate with pirarubicin: In vitro and ex vivo stability and drug release study W Islam, J Fang, T Etrych, P Chytil, K Ulbrich, A Sakoguchi, K Kusakabe, ... International journal of pharmaceutics 536 (1), 108-115, 2018 | 16 | 2018 |
Unraveling the role of Intralipid in suppressing off-target delivery and augmenting the therapeutic effects of anticancer nanomedicines R Islam, S Gao, W Islam, V Šubr, JR Zhou, K Yokomizo, T Etrych, ... Acta Biomaterialia 126, 372-383, 2021 | 11 | 2021 |
Synthesis of PEGylated manganese protoporphyrin as a catalase mimic and its therapeutic application to acetaminophen-induced acute liver failure T Zhang, J Fang, H Tsutsuki, K Ono, W Islam, T Sawa Biological and Pharmaceutical Bulletin 42 (7), 1199-1206, 2019 | 9 | 2019 |
Preparation of function-enhanced vegetable oils H Maeda, T Satoh, W Islam Functional Foods in Health and Disease 6 (1), 33-41, 2016 | 4 | 2016 |
Weak Interplay between Hydrophobic Part of Water-soluble Polymers and Serum Protein S Takano, W Islam, S Fujii, H Maeda, K Sakurai Chemistry Letters 50 (7), 1392-1393, 2021 | 3 | 2021 |
Structural Determination of the Nanocomplex of Borate with Styrene–Maleic Acid Copolymer-Conjugated Glucosamine Used as a Multifunctional Anticancer Drug W Islam, H Tsutsuki, K Ono, A Harada, K Shinozaki, T Niidome, J Fang, ... ACS Applied Bio Materials 5 (12), 5953-5964, 2022 | 1 | 2022 |
Pegylated manganese protoporphyrin self-assembles into nanoparticles in aqueous media and exerts potent catalase-mimic activity to protect oxidative cellular damages T Zhang, J Fang, K Ono, W Islam, H Tsutsuki, T Sawa Free Radical Biology and Medicine 128, S120, 2018 | 1 | 2018 |