Niemann-Pick disease type C1 is a sphingosine storage disease that causes deregulation of lysosomal calcium E Lloyd-Evans, AJ Morgan, X He, DA Smith, E Elliot-Smith, DJ Sillence, ... Nature medicine 14 (11), 1247-1255, 2008 | 913 | 2008 |
Accumulation of glycosphingolipids in Niemann-Pick C disease disrupts endosomal transport D te Vruchte, E Lloyd-Evans, RJ Veldman, DCA Neville, RA Dwek, ... Journal of Biological Chemistry 279 (25), 26167-26175, 2004 | 235 | 2004 |
Treatment with miglustat reverses the lipid-trafficking defect in Niemann–Pick disease type C RH Lachmann, D te Vruchte, E Lloyd-Evans, G Reinkensmeier, ... Neurobiology of disease 16 (3), 654-658, 2004 | 221 | 2004 |
Analysis of fluorescently labeled glycosphingolipid-derived oligosaccharides following ceramide glycanase digestion and anthranilic acid labeling DCA Neville, V Coquard, DA Priestman, DJM te Vruchte, DJ Sillence, ... Analytical biochemistry 331 (2), 275-282, 2004 | 207 | 2004 |
Glucosylceramide modulates membrane traffic along the endocytic pathway DJ Sillence, V Puri, DL Marks, TD Butters, RA Dwek, RE Pagano, FM Platt Journal of lipid research 43 (11), 1837-1845, 2002 | 154 | 2002 |
Role of multiple drug resistance protein 1 in neutral but not acidic glycosphingolipid biosynthesis MF De Rosa, D Sillence, C Ackerley, C Lingwood Journal of Biological Chemistry 279 (9), 7867-7876, 2004 | 127 | 2004 |
The association of Shiga-like toxin with detergent-resistant membranes is modulated by glucosylceramide and is an essential requirement in the endoplasmic reticulum for a … DC Smith, DJ Sillence, T Falguieres, RM Jarvis, L Johannes, JM Lord, ... Molecular biology of the cell 17 (3), 1375-1387, 2006 | 103 | 2006 |
Relative acidic compartment volume as a lysosomal storage disorder–associated biomarker D Te Vruchte, AO Speak, KL Wallom, N Al Eisa, DA Smith, CJ Hendriksz, ... The Journal of clinical investigation 124 (3), 1320-1328, 2014 | 88 | 2014 |
Niemann–Pick type C disease: cellular pathology and pharmacotherapy S Wheeler, DJ Sillence Journal of neurochemistry 153 (6), 674-692, 2020 | 86 | 2020 |
Evidence against an early signalling role for ceramide in Fas-mediated apoptosis DJ Sillence, D ALLAN Biochemical Journal 324 (1), 29-32, 1997 | 67 | 1997 |
Glucosylceramide modulates endolysosomal pH in Gaucher disease DJ Sillence Molecular Genetics and Metabolism 109 (2), 194-200, 2013 | 51 | 2013 |
Storage diseases: new insights into sphingolipid functions DJ Sillence, FM Platt Trends in cell biology 13 (4), 195-203, 2003 | 46 | 2003 |
New insights into glycosphingolipid functions—storage, lipid rafts, and translocators DJ Sillence International review of cytology 262, 151-189, 2007 | 45 | 2007 |
The subcellular sites of sphingomyelin synthesis in BHK cells MJM Obradors, D Sillence, S Howitt, D Allan Biochimica et Biophysica Acta (BBA)-Molecular Cell Research 1359 (1), 1-12, 1997 | 41 | 1997 |
Glycosphingolipids in endocytic membrane transport DJ Sillence, FM Platt Seminars in cell & developmental biology 15 (4), 409-416, 2004 | 40 | 2004 |
Cytosolic glucosylceramide regulates endolysosomal function in Niemann-Pick type C disease S Wheeler, P Haberkant, M Bhardwaj, P Tongue, MJ Ferraz, D Halter, ... Neurobiology of disease 127, 242-252, 2019 | 28 | 2019 |
Utilization of phosphatidylcholine and production of diradylglycerol as a consequence of sphingomyelin synthesis DJ SILLENCE, D ALLAN Biochemical Journal 331 (1), 251-256, 1998 | 23 | 1998 |
Lipid–protein interactions in Niemann–Pick type C disease: insights from molecular modeling S Wheeler, R Schmid, DJ Sillence International Journal of Molecular Sciences 20 (3), 717, 2019 | 22 | 2019 |
Subcellular distribution of agonist-stimulated phosphatidylinositol synthesis in 1321 N1 astrocytoma cells DJ Sillence, CP Downes Biochemical Journal 290 (2), 381-387, 1993 | 22 | 1993 |
Lithium treatment of affective disorders: effects of lithium on the inositol phospholipid and cyclic AMP signalling pathways DJ Sillence, CP Downes Biochimica et Biophysica Acta (BBA)-Molecular Basis of Disease 1138 (1), 46-52, 1992 | 22 | 1992 |