| Compartmentation of cyclic nucleotide signaling in the heart: the role of cyclic nucleotide phosphodiesterases R Fischmeister, LRV Castro, A Abi-Gerges, F Rochais, J Jurevicius, ... Circulation research 99 (8), 816-828, 2006 | 451 | 2006 |
| The cAMP binding protein Epac modulates Ca2+ sparks by a Ca2+/calmodulin kinase signalling pathway in rat cardiac myocytes L Pereira, M Métrich, M Fernández‐Velasco, A Lucas, J Leroy, R Perrier, ... The Journal of physiology 583 (2), 685-694, 2007 | 264 | 2007 |
| Spatiotemporal Dynamics of β-Adrenergic cAMP Signals and L-Type Ca2+ Channel Regulation in Adult Rat Ventricular Myocytes: Role of Phosphodiesterases J Leroy, A Abi-Gerges, VO Nikolaev, W Richter, P Lechêne, JL Mazet, ... Circulation research 102 (9), 1091-1100, 2008 | 176 | 2008 |
| PDEs create local domains of cAMP signaling D Mika, J Leroy, G Vandecasteele, R Fischmeister Journal of molecular and cellular cardiology 52 (2), 323-329, 2012 | 171 | 2012 |
| Phosphodiesterase 4B in the cardiac L-type Ca2+ channel complex regulates Ca2+ current and protects against ventricular arrhythmias in mice J Leroy, W Richter, D Mika, LRV Castro, A Abi-Gerges, M Xie, ... The Journal of clinical investigation 121 (7), 2651-2661, 2011 | 160 | 2011 |
| Phosphodiesterase-2 is up-regulated in human failing hearts and blunts β-adrenergic responses in cardiomyocytes H Mehel, J Emons, C Vettel, K Wittköpper, D Seppelt, M Dewenter, S Lutz, ... Journal of the American College of Cardiology 62 (17), 1596-1606, 2013 | 149 | 2013 |
| Cyclic adenosine monophosphate phosphodiesterase type 4 protects against atrial arrhythmias CE Molina, J Leroy, W Richter, M Xie, C Scheitrum, IO Lee, C Maack, ... Journal of the American College of Cardiology 59 (24), 2182-2190, 2012 | 137 | 2012 |
| Cyclic nucleotide phosphodiesterases in heart and vessels: a therapeutic perspective P Bobin, M Belacel-Ouari, I Bedioune, L Zhang, J Leroy, V Leblais, ... Archives of cardiovascular diseases 109 (6-7), 431-443, 2016 | 121 | 2016 |
| Interaction via a key tryptophan in the I-II linker of N-type calcium channels is required for β1 but not for palmitoylated β2, implicating an additional binding site in the … J Leroy, MS Richards, AJ Butcher, M Nieto-Rostro, WS Pratt, A Davies, ... Journal of Neuroscience 25 (30), 6984-6996, 2005 | 101 | 2005 |
| Dominant-negative calcium channel suppression by truncated constructs involves a kinase implicated in the unfolded protein response KM Page, F Heblich, A Davies, AJ Butcher, J Leroy, F Bertaso, WS Pratt, ... Journal of Neuroscience 24 (23), 5400-5409, 2004 | 91 | 2004 |
| Ca2+ currents in cardiac myocytes: old story, new insights F Brette, J Leroy, JY Le Guennec, L Sallé Progress in biophysics and molecular biology 91 (1-2), 1-82, 2006 | 89 | 2006 |
| Phosphoinositide 3-kinase γ protects against catecholamine-induced ventricular arrhythmia through protein kinase a–mediated regulation of distinct phosphodiesterases A Ghigo, A Perino, H Mehel, A Zahradníková Jr, F Morello, J Leroy, ... Circulation 126 (17), 2073-2083, 2012 | 84 | 2012 |
| Phosphodiesterase 2 protects against catecholamine-induced arrhythmia and preserves contractile function after myocardial infarction C Vettel, M Lindner, M Dewenter, K Lorenz, C Schanbacher, M Riedel, ... Circulation research 120 (1), 120-132, 2017 | 80 | 2017 |
| Association between antithrombotic treatment and outcomes at 1-year follow-up in patients with atrial fibrillation: the EORP-AF General Long-Term Registry G Boriani, M Proietti, C Laroche, L Fauchier, F Marin, M Nabauer, ... EP Europace 21 (7), 1013-1022, 2019 | 67 | 2019 |
| Alternate splicing in the cytosolic II–III loop and the carboxy terminus of human E-type voltage-gated Ca2+ channels: electrophysiological characterization of isoforms A Pereverzev, J Leroy, A Krieger, CO Malécot, J Hescheler, G Pfitzer, ... Molecular and Cellular Neuroscience 21 (2), 352-365, 2002 | 65 | 2002 |
| Cardiac overexpression of PDE4B blunts β-adrenergic response and maladaptive remodeling in heart failure S Karam, JP Margaria, A Bourcier, D Mika, A Varin, I Bedioune, M Lindner, ... Circulation 142 (2), 161-174, 2020 | 62 | 2020 |
| Differential regulation of cardiac excitation–contraction coupling by cAMP phosphodiesterase subtypes D Mika, P Bobin, M Pomerance, P Lechêne, RE Westenbroek, ... Cardiovascular research 100 (2), 336-346, 2013 | 61 | 2013 |
| The HOOK-Domain Between the SH3- and the GK-Domains of CaVβ Subunits Contains Key Determinants Controlling Calcium Channel Inactivation MW Richards, J Leroy, WS Pratt, AC Dolphin Channels 1 (2), 92-101, 2007 | 51 | 2007 |
| The stargazin-related protein γ7 interacts with the mRNA-binding protein heterogeneous nuclear ribonucleoprotein A2 and regulates the stability of specific mRNAs, including Cav2. 2 L Ferron, A Davies, KM Page, DJ Cox, J Leroy, D Waithe, AJ Butcher, ... Journal of Neuroscience 28 (42), 10604-10617, 2008 | 48 | 2008 |
| Cyclic nucleotide phosphodiesterases as therapeutic targets in cardiac hypertrophy and heart failure R Kamel, J Leroy, G Vandecasteele, R Fischmeister Nature Reviews Cardiology 20 (2), 90-108, 2023 | 47 | 2023 |
