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Nicholas Seyfried
Nicholas Seyfried
Professor of Biochemistry, Emory School of Medicine
Verified email at emory.edu - Homepage
Title
Cited by
Cited by
Year
Quantitative proteomics reveals the function of unconventional ubiquitin chains in proteasomal degradation
P Xu, DM Duong, NT Seyfried, D Cheng, Y Xie, J Robert, J Rush, ...
Cell 137 (1), 133-145, 2009
13802009
Large-scale proteomic analysis of Alzheimer’s disease brain and cerebrospinal fluid reveals early changes in energy metabolism associated with microglia and astrocyte activation
ECB Johnson, EB Dammer, DM Duong, L Ping, M Zhou, L Yin, ...
Nature medicine 26 (5), 769-780, 2020
6232020
Continuous release of endostatin from microencapsulated engineered cells for tumor therapy
T Joki, M Machluf, A Atala, J Zhu, NT Seyfried, IF Dunn, T Abe, RS Carroll, ...
Nature biotechnology 19 (1), 35-39, 2001
4872001
TDP-43 pathology disrupts nuclear pore complexes and nucleocytoplasmic transport in ALS/FTD
CC Chou, YI Zhang, ME Umoh, SW Vaughan, I Lorenzini, F Liu, ...
Nature neuroscience 21 (2), 228-239, 2018
4812018
Cleavage of tau by asparagine endopeptidase mediates the neurofibrillary pathology in Alzheimer's disease
Z Zhang, M Song, X Liu, SS Kang, IS Kwon, DM Duong, NT Seyfried, ...
Nature medicine 20 (11), 1254-1262, 2014
4032014
Evidence for brain glucose dysregulation in Alzheimer's disease
Y An, VR Varma, S Varma, R Casanova, E Dammer, O Pletnikova, ...
Alzheimer's & dementia 14 (3), 318-329, 2018
3962018
A multi-network approach identifies protein-specific co-expression in asymptomatic and symptomatic Alzheimer’s disease
NT Seyfried, EB Dammer, V Swarup, D Nandakumar, DM Duong, L Yin, ...
Cell systems 4 (1), 60-72. e4, 2017
3872017
Expression of cyclooxygenase 2 (COX-2) in human glioma and in vitro inhibition by a specific COX-2 inhibitor, NS-398
T Joki, O Heese, DC Nikas, L Bello, J Zhang, SK Kraeft, NT Seyfried, ...
Cancer research 60 (17), 4926-4931, 2000
3772000
Posttranslational modifications mediate the structural diversity of tauopathy strains
T Arakhamia, CE Lee, Y Carlomagno, M Kumar, DM Duong, H Wesseling, ...
Cell 180 (4), 633-644. e12, 2020
3292020
Glutamate dehydrogenase 1 signals through antioxidant glutathione peroxidase 1 to regulate redox homeostasis and tumor growth
L Jin, D Li, GN Alesi, J Fan, HB Kang, Z Lu, TJ Boggon, P Jin, H Yi, ...
Cancer cell 27 (2), 257-270, 2015
3202015
The Mount Sinai cohort of large-scale genomic, transcriptomic and proteomic data in Alzheimer's disease
M Wang, ND Beckmann, P Roussos, E Wang, X Zhou, Q Wang, C Ming, ...
Scientific data 5 (1), 1-16, 2018
3062018
Identification and therapeutic modulation of a pro-inflammatory subset of disease-associated-microglia in Alzheimer’s disease
S Rangaraju, EB Dammer, SA Raza, P Rathakrishnan, H Xiao, T Gao, ...
Molecular neurodegeneration 13, 1-25, 2018
3042018
U1 small nuclear ribonucleoprotein complex and RNA splicing alterations in Alzheimer’s disease
B Bai, CM Hales, PC Chen, Y Gozal, EB Dammer, JJ Fritz, X Wang, Q Xia, ...
Proceedings of the National Academy of Sciences 110 (41), 16562-16567, 2013
3002013
Delta-secretase cleaves amyloid precursor protein and regulates the pathogenesis in Alzheimer’s disease
Z Zhang, M Song, X Liu, S Su Kang, DM Duong, NT Seyfried, X Cao, ...
Nature communications 6 (1), 8762, 2015
2572015
Large-scale deep multi-layer analysis of Alzheimer’s disease brain reveals strong proteomic disease-related changes not observed at the RNA level
ECB Johnson, EK Carter, EB Dammer, DM Duong, ES Gerasimov, Y Liu, ...
Nature neuroscience 25 (2), 213-225, 2022
2292022
Integrated proteomics reveals brain-based cerebrospinal fluid biomarkers in asymptomatic and symptomatic Alzheimer’s disease
L Higginbotham, L Ping, EB Dammer, DM Duong, M Zhou, M Gearing, ...
Science advances 6 (43), eaaz9360, 2020
2102020
Polyubiquitin linkage profiles in three models of proteolytic stress suggest the etiology of Alzheimer disease
EB Dammer, CH Na, P Xu, NT Seyfried, DM Duong, D Cheng, M Gearing, ...
Journal of biological chemistry 286 (12), 10457-10465, 2011
2102011
Integrating human brain proteomes with genome-wide association data implicates new proteins in Alzheimer’s disease pathogenesis
AP Wingo, Y Liu, ES Gerasimov, J Gockley, BA Logsdon, DM Duong, ...
Nature genetics 53 (2), 143-146, 2021
1802021
Global quantitative analysis of the human brain proteome in Alzheimer’s and Parkinson’s Disease
L Ping, DM Duong, L Yin, M Gearing, JJ Lah, AI Levey, NT Seyfried
Scientific data 5 (1), 1-12, 2018
1802018
Deep proteomic network analysis of Alzheimer’s disease brain reveals alterations in RNA binding proteins and RNA splicing associated with disease
ECB Johnson, EB Dammer, DM Duong, L Yin, M Thambisetty, ...
Molecular neurodegeneration 13, 1-22, 2018
1702018
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