The aryl-ureido fatty acid CTU activates endoplasmic reticulum stress and PERK/NOXA-mediated apoptosis in tumor cells by a dual mitochondrial-targeting mechanism H Choucair, MK Rahman, B Umashankar, Y Al-Zubaidi, K Bourget, ... Cancer Letters 526, 131-141, 2022 | 9 | 2022 |
Aryl-urea fatty acids that activate the p38 MAP kinase and down-regulate multiple cyclins decrease the viability of MDA-MB-231 breast cancer cells Y Al-Zubaidi, C Pazderka, N Koolaji, MK Rahman, H Choucair, ... European Journal of Pharmaceutical Sciences 129, 87-98, 2019 | 6 | 2019 |
Molecular and Functional Characteristics of Airway Epithelium under Chronic Hypoxia SL Wong, E Kardia, A Vijayan, B Umashankar, E Pandzic, L Zhong, ... International Journal of Molecular Sciences 24 (7), 6475, 2023 | 1 | 2023 |
Inclusion of the in-chain sulfur in 3-thiaCTU increases the efficiency of mitochondrial targeting and cell killing by anticancer aryl-urea fatty acids MK Rahman, B Umashankar, H Choucair, C Pazderka, K Bourget, Y Chen, ... European Journal of Pharmacology 939, 175470, 2023 | 1 | 2023 |
PTU, a novel ureido-fatty acid, inhibits MDA-MB-231 cell invasion and dissemination by modulating Wnt5a secretion and cytoskeletal signaling Y Al-Zubaidi, Y Chen, MK Rahman, B Umashankar, H Choucair, ... Biochemical pharmacology 192, 114726, 2021 | 1 | 2021 |
The inositol-requiring enzyme 1 (IRE1) endoplasmic reticulum stress pathway promotes MDA-MB-231 cell survival and renewal in response to the aryl-ureido fatty acid CTU MK Rahman, B Umashankar, H Choucair, K Bourget, T Rawling, ... The International Journal of Biochemistry & Cell Biology 171, 106571, 2024 | | 2024 |
A novel fatty acid metabolite analogue activates cell death mechanisms in human breast cancer cells. B Umashankar | | 2021 |
Inhibition of IRE1-mediated pro-tumorigenic responses enhances the sensitivity of MDA-MB-231 cells to the novel arylurea-fatty acid CTU MK Rahman, T Rawling, Y Al-Zubaidi, H Choucair, B Umashankar, ... MOLECULAR CANCER THERAPEUTICS 18 (12), 2019 | | 2019 |
Abstract A119: Inhibition of IRE1-mediated pro-tumorigenic responses enhances the sensitivity of MDA-MB-231 cells to the novel arylurea-fatty acid CTU MK Rahman, T Rawling, Y Al-Zubaidi, H Choucair, B Umashankar, ... Molecular Cancer Therapeutics 18 (12_Supplement), A119-A119, 2019 | | 2019 |