The structure-based design of SARS-CoV-2 nsp14 methyltransferase ligands yields nanomolar inhibitors T Otava, M Sala, F Li, J Fanfrlik, K Devkota, S Perveen, I Chau, P Pakarian, ... ACS infectious diseases 7 (8), 2214-2220, 2021 | 67 | 2021 |
Probing the SAM binding site of SARS-CoV-2 Nsp14 in vitro using SAM competitive inhibitors guides developing selective bisubstrate inhibitors K Devkota, M Schapira, S Perveen, A Khalili Yazdi, F Li, I Chau, P Ghiabi, ... SLAS DISCOVERY: Advancing the Science of Drug Discovery 26 (9), 1200-1211, 2021 | 64 | 2021 |
A high-throughput RNA displacement assay for screening SARS-CoV-2 nsp10-nsp16 complex toward developing therapeutics for COVID-19 S Perveen, A Khalili Yazdi, K Devkota, F Li, P Ghiabi, T Hajian, ... SLAS DISCOVERY: Advancing the Science of Drug Discovery 26 (5), 620-627, 2021 | 28 | 2021 |
A high-throughput radioactivity-based assay for screening SARS-CoV-2 nsp10-nsp16 complex A Khalili Yazdi, F Li, K Devkota, S Perveen, P Ghiabi, T Hajian, ... SLAS DISCOVERY: Advancing the Science of Drug Discovery 26 (6), 757-765, 2021 | 22 | 2021 |
SS148 and WZ16 inhibit the activities of nsp10-nsp16 complexes from all seven human pathogenic coronaviruses F Li, P Ghiabi, T Hajian, M Klima, ASM Li, AK Yazdi, I Chau, P Loppnau, ... Biochimica et Biophysica Acta (BBA)-General Subjects 1867 (4), 130319, 2023 | 13 | 2023 |
Anthranilate phosphoribosyltransferase from the hyperthermophilic archaeon Thermococcus kodakarensis shows maximum activity with zinc and forms a unique … S Perveen, N Rashid, XF Tang, T Imanaka, AC Papageorgiou FEBS Open bio 7 (8), 1217-1230, 2017 | 13 | 2017 |
Kinetic characterization of SARS-CoV-2 nsp13 ATPase activity and discovery of small-molecule inhibitors AK Yazdi, P Pakarian, S Perveen, T Hajian, V Santhakumar, A Bolotokova, ... ACS Infectious Diseases 8 (8), 1533-1542, 2022 | 9 | 2022 |
Pcal_1127, a highly stable and efficient ribose-5-phosphate pyrophosphokinase from Pyrobaculum calidifontis T Bibi, S Perveen, I Aziz, Q Bashir, N Rashid, T Imanaka, M Akhtar Extremophiles 20, 821-830, 2016 | 9 | 2016 |
Extremely stable indole-3-glycerol-phosphate synthase from hyperthermophilic archaeon Pyrococcus furiosus M Arif, N Rashid, S Perveen, Q Bashir, M Akhtar Extremophiles 23, 69-77, 2019 | 8 | 2019 |
Chemical tools for the Gid4 subunit of the human E3 ligase C-terminal to LisH (CTLH) degradation complex AK Yazdi, S Perveen, C Dong, X Song, A Dong, MM Szewczyk, ... RSC Medicinal Chemistry 15 (3), 1066-1071, 2024 | 3 | 2024 |
Probing the mechanism of Cbl-b inhibition by a small-molecule inhibitor S Kimani, S Perveen, M Szewezyk, H Zeng, A Dong, F Li, P Ghiabi, Y Li, ... bioRxiv, 2023.05. 05.539612, 2023 | 3 | 2023 |
Crystal structure of a phosphoribosyl anthranilate isomerase from the hyperthermophilic archaeon Thermococcus kodakaraensis S Perveen, N Rashid, AC Papageorgiou Acta Crystallographica Section F: Structural Biology Communications 72 (11 …, 2016 | 3 | 2016 |
Development of Complementary Photo‐arginine/lysine to Promote Discovery of Arg/Lys Hptms Interactomes Y Zong, N Weiss, K Wang, AE Pagano, S Heissel, S Perveen, J Huang Advanced Science, 2307526, 2024 | 1 | 2024 |
The co-crystal structure of Cbl-b and a small-molecule inhibitor reveals the mechanism of Cbl-b inhibition SW Kimani, S Perveen, M Szewezyk, H Zeng, A Dong, F Li, P Ghiabi, Y Li, ... Communications Biology 6 (1), 1272, 2023 | 1 | 2023 |
Discovery of small molecule antagonists of human Retinoblastoma Binding Protein 4 (RBBP4) S Perveen, CA Zepeda-Velázquez, D McLeod, R Marcellus, ... bioRxiv, 2022.01. 05.475077, 2022 | 1 | 2022 |
Development of Peptide Displacement Assays to Screen for Antagonists of DDB1 Interactions D Yong, S Ahmad, MF Mabanglo, L Halabelian, M Schapira, S Ackloo, ... Biochemistry, 2024 | | 2024 |
Kinetic characterization of human mRNA guanine-N7 methyltransferase S Perveen, AK Yazdi, T Hajian, F Li, M Vedadi Scientific Reports 14 (1), 4509, 2024 | | 2024 |
Application of Established Computational Techniques to Identify Potential SARS-CoV-2 Nsp14-MTase Inhibitors in Low Data Regimes AK Nigam, MFD Hurley, F Lu, E Konkoľová, M Klima, J Trylčová, R Pollice, ... Digital Discovery, 2024 | | 2024 |
A resource to enable chemical biology and drug discovery of WDR Proteins CH Arrowsmith, S Ackloo, F Li, M Szewczyk, A Seitova, P Loppnau, ... bioRxiv, 2024.03. 03.583197, 2024 | | 2024 |
Drug Discovery in Low Data Regimes: Leveraging a Computational Pipeline for the Discovery of Novel SARS-CoV-2 Nsp14-MTase Inhibitors AK Nigam, MFD Hurley, F Li, E Konkoľová, M Klíma, J Trylčová, R Pollice, ... bioRxiv, 2023 | | 2023 |