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Fred Guengerich
Fred Guengerich
Professor of Biochemistry, Vanderbilt University
Verified email at vanderbilt.edu - Homepage
Title
Cited by
Cited by
Year
Interindividual variations in human liver cytochrome P-450 enzymes involved in the oxidation of drugs, carcinogens and toxic chemicals: studies with liver microsomes of 30 …
T Shimada, H Yamazaki, M Mimura, Y Inui, FP Guengerich
Journal of pharmacology and experimental therapeutics 270 (1), 414-423, 1994
36761994
Membrane transporters in drug development
Nature reviews Drug discovery 9 (3), 215-236, 2010
35912010
The P450 superfamily: update on new sequences, gene mapping, accession numbers, early trivial names of enzymes, and nomenclature
DR Nelson, T Kamataki, DJ Waxman, FP Guengerich, RW Estabrook, ...
DNA and cell biology 12 (1), 1-51, 1993
22911993
Common and uncommon cytochrome P450 reactions related to metabolism and chemical toxicity
FP Guengerich
Chemical research in toxicology 14 (6), 611-650, 2001
21952001
Cytochrome p450 and chemical toxicology
FP Guengerich
Chemical research in toxicology 21 (1), 70-83, 2008
20502008
The P450 superfamily: updated listing of all genes and recommended nomenclature for the chromosomal loci
DW Nebert, DR Nelson, M Adesnik, MJ Coon, RW Estabrook, ...
Dna 8 (1), 1-13, 1989
18931989
Cytochrome P-450 3A4: regulation and role in drug metabolism
FP Guengerich
Annual review of pharmacology and toxicology 39 (1), 1-17, 1999
16051999
Role of human cytochrome P-450 IIE1 in the oxidation of many low molecular weight cancer suspects
FP Guengerich, DH Kim, M Iwasaki
Chemical research in toxicology 4 (2), 168-179, 1991
15791991
The P450 superfamily: update on new sequences, gene mapping, and recommended nomenclature
DW NEBERT, DR NELSON, MJ COON, RW ESTABROOK, ...
DNA and cell biology 10 (1), 1-14, 1991
14351991
Oxidation of toxic and carcinogenic chemicals by human cytochrome P-450 enzymes
FP Guengerich, T Shimada
Chemical research in toxicology 4 (4), 391-407, 1991
13871991
Purification and characterization of liver microsomal cytochromes P-450: electrophoretic, spectral, catalytic, and immunochemical properties and inducibility of eight isozymes …
FP Guengerich, GA Dannan, ST Wright, MV Martin, LS Kaminsky
Biochemistry 21 (23), 6019-6030, 1982
13261982
Mapping the genetic architecture of gene expression in human liver
EE Schadt, C Molony, E Chudin, K Hao, X Yang, PY Lum, A Kasarskis, ...
PLoS biology 6 (5), e107, 2008
12002008
Activation of chemically diverse procarcinogens by human cytochrome P-450 1B1
T Shimada, CL Hayes, H Yamazaki, S Amin, SS Hecht, FP Guengerich, ...
Cancer research 56 (13), 2979-2984, 1996
10411996
Characterization of rat and human liver microsomal cytochrome P-450 forms involved in nifedipine oxidation, a prototype for genetic polymorphism in oxidative drug metabolism.
FP Guengerich, MV Martin, PH Beaune, P Kremers, T Wolff, DJ Waxman
Journal of Biological Chemistry 261 (11), 5051-5060, 1986
9901986
Reactions and significance of cytochrome P-450 enzymes
FP Guengerich
Journal of Biological Chemistry 266 (16), 10019-10022, 1991
9331991
Human cytochrome P-450PA (P-450IA2), the phenacetin O-deethylase, is primarily responsible for the hepatic 3-demethylation of caffeine and N-oxidation of carcinogenic arylamines.
MA Butler, M Iwasaki, FP Guengerich, FF Kadlubar
Proceedings of the National Academy of Sciences 86 (20), 7696-7700, 1989
8681989
Cytochrome P450s and other enzymes in drug metabolism and toxicity
FP Guengerich
The AAPS journal 8, E101-E111, 2006
8232006
Chemical mechanisms of catalysis by cytochromes P-450: a unified view
FP Guengerich, TL Macdonald
Accounts of Chemical Research 17 (1), 9-16, 1984
8161984
Dealkylation of pentoxyresorufin: a rapid and sensitive assay for measuring induction of cytochrome (s) P-450 by phenobarbital and other xenobiotics in the rat
RA Lubet, RT Mayer, JW Cameron, RW Nims, MD Burke, T Wolff, ...
Archives of biochemistry and biophysics 238 (1), 43-48, 1985
7801985
Regulation of rat hepatic cytochrome P-450: age-dependent expression, hormonal imprinting, and xenobiotic inducibility of sex-specific isoenzymes
DJ Waxman, GA Dannan, FP Guengerich
Biochemistry 24 (16), 4409-4417, 1985
7381985
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