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Tomás Sou
Tomás Sou
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New developments in dry powder pulmonary vaccine delivery
T Sou, EN Meeusen, M de Veer, DAV Morton, LM Kaminskas, ...
Trends in biotechnology 29 (4), 191-198, 2011
1652011
The effect of amino acid excipients on morphology and solid-state properties of multi-component spray-dried formulations for pulmonary delivery of biomacromolecules
T Sou, LM Kaminskas, TH Nguyen, R Carlberg, MP McIntosh, DAV Morton
European Journal of Pharmaceutics and Biopharmaceutics 83 (2), 234-243, 2013
1552013
Investigating the interactions of amino acid components on a mannitol-based spray-dried powder formulation for pulmonary delivery: a design of experiment approach
T Sou, L Orlando, MP McIntosh, LM Kaminskas, DAV Morton
International journal of pharmaceutics 421 (2), 220-229, 2011
712011
Spray-dried influenza antigen with trehalose and leucine produces an aerosolizable powder vaccine formulation that induces strong systemic and mucosal immunity after pulmonary …
T Sou, DAV Morton, M Williamson, EN Meeusen, LM Kaminskas, ...
Journal of aerosol medicine and pulmonary drug delivery 28 (5), 361-371, 2015
572015
Automated assays for thermodynamic (equilibrium) solubility determination
T Sou, CAS Bergström
Drug Discovery Today: Technologies 27, 11-19, 2018
532018
Hit Identification of New Potent PqsR Antagonists as Inhibitors of Quorum Sensing in Planktonic and Biofilm Grown Pseudomonas aeruginosa
F Soukarieh, R Liu, M Romero, SN Roberston, W Richardson, S Lucanto, ...
Frontiers in Chemistry 8, 204, 2020
412020
Contemporary formulation development for inhaled pharmaceuticals
T Sou, CAS Bergström
Journal of Pharmaceutical Sciences 110 (1), 66-86, 2021
382021
Model‐informed drug development for antimicrobials: translational PK and PK/PD modeling to predict an efficacious human dose for apramycin
T Sou, J Hansen, E Liepinsh, M Backlund, O Ercan, S Grinberga, S Cao, ...
Clinical Pharmacology & Therapeutics 109 (4), 1063-1073, 2021
282021
Design and Evaluation of New Quinazolin-4(3H)-one Derived PqsR Antagonists as Quorum Sensing Quenchers in Pseudomonas aeruginosa
F Soukarieh, A Mashabi, W Richardson, EV Oton, M Romero, ...
ACS Infectious Diseases 7 (9), 2666-2685, 2021
262021
Population pharmacokinetics of piperacillin in plasma and subcutaneous tissue in patients on continuous renal replacement therapy
M Bue, T Sou, ASL Okkels, P Hanberg, A Thorsted, LE Friberg, ...
International Journal of Infectious Diseases 92, 133-140, 2020
262020
Designing a multi-component spray-dried formulation platform for pulmonary delivery of biopharmaceuticals: the use of polyol, disaccharide, polysaccharide and synthetic polymer …
T Sou, RT Forbes, J Gray, RJ Prankerd, LM Kaminskas, MP McIntosh, ...
Powder technology 287, 248-255, 2016
252016
Designing a multicomponent spray-dried formulation platform for pulmonary delivery of biomacromolecules: the effect of polymers on the formation of an amorphous matrix for …
T Sou, MP McIntosh, LM Kaminskas, RJ Prankerd, DAV Morton
Drying technology 31 (13-14), 1451-1458, 2013
202013
Model-based drug development in pulmonary delivery: pharmacokinetic analysis of novel drug candidates for treatment of Pseudomonas aeruginosa lung infection
T Sou, I Kukavica-Ibrulj, F Soukarieh, N Halliday, RC Levesque, ...
Journal of Pharmaceutical Sciences 108 (1), 630-640, 2019
182019
Model-informed drug development in pulmonary delivery: semimechanistic pharmacokinetic–pharmacodynamic modeling for evaluation of treatments against chronic Pseudomonas …
T Sou, I Kukavica-Ibrulj, RC Levesque, LE Friberg, CAS Bergström
Molecular Pharmaceutics 17 (5), 1458-1469, 2020
102020
Pulmonary and systemic pharmacokinetics of colistin methanesulfonate (CMS) and formed colistin following nebulisation of CMS among patients with ventilator-associated pneumonia
A Gkoufa, T Sou, I Karaiskos, C Routsi, YW Lin, M Psichogiou, ...
International Journal of Antimicrobial Agents 59 (6), 106588, 2022
82022
Model-informed drug discovery and development in pulmonary delivery: biopharmaceutical Pharmacometric Modeling for formulation evaluation of pulmonary suspensions
T Sou, F Soukarieh, P Williams, MJ Stocks, M Cámara, CAS Bergström
ACS omega 5 (40), 25733-25746, 2020
62020
Method and formulation for inhalation
M McIntosh, D Morton, T Sou, L Olerile, R Prankerd
US Patent 11,065,297, 2021
22021
Method and formulation for inhalation
M McIntosh, D Morton, T Sou, L Olerile, R Prankerd
US Patent App. 14/236,465, 2014
12014
The role and interaction effects of amino acids on the particle engineering of a mannitol-based powder formulation
DAV Morton, T Sou, LM Kaminskas, MP McIntosh, L Orlando
The electronic conference on pharmaceutical sciences ECPS, 1-6, 2011
12011
Investigating effects of surface modifications on a mannitol dry powder inhaler plume by laser diffraction
DAV Morton, MP McIntosh, T Sou
Respiratory Drug Delivery 2008, 649-653, 2008
12008
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