| ARHI (DIRAS3) induces autophagy in ovarian cancer cells by downregulating the epidermal growth factor receptor, inhibiting PI3K and Ras/MAP signaling and activating the FOXo3a … Z Lu, H Yang, MN Sutton, M Yang, CH Clarke, WSL Liao, RC Bast Cell Death & Differentiation 21 (8), 1275-1289, 2014 | 84 | 2014 |
| ARHI (DIRAS3)-mediated autophagy-associated cell death enhances chemosensitivity to cisplatin in ovarian cancer cell lines and xenografts MN Washington, G Suh, AF Orozco, MN Sutton, H Yang, Y Wang, W Mao, ... Cell Death & Disease 6 (8), e1836-e1836, 2015 | 63 | 2015 |
| RAS-related GTPases DIRAS1 and DIRAS2 induce autophagic cancer cell death and are required for autophagy in murine ovarian cancer cells MN Sutton, H Yang, GY Huang, C Fu, M Pontikos, Y Wang, W Mao, ... Autophagy 14 (4), 637-653, 2018 | 54 | 2018 |
| DIRAS3 (ARHI) blocks RAS/MAPK signaling by binding directly to RAS and disrupting RAS clusters MN Sutton, Z Lu, YC Li, Y Zhou, T Huang, AS Reger, AM Hurwitz, ... Cell reports 29 (11), 3448-3459. e6, 2019 | 52 | 2019 |
| Tumor necrosis factor-α and interferon-γ stimulate MUC16 (CA125) expression in breast, endometrial and ovarian cancers through NFκB M Morgado, MN Sutton, M Simmons, CR Warren, Z Lu, PE Constantinou, ... Oncotarget 7 (12), 14871, 2016 | 52 | 2016 |
| The role of vascular endothelial growth factor, interleukin 8, and insulinlike growth factor in sustaining autophagic DIRAS3‐induced dormant ovarian cancer xenografts W Mao, HL Peters, MN Sutton, AF Orozco, L Pang, H Yang, Z Lu, ... Cancer 125 (8), 1267-1280, 2019 | 30 | 2019 |
| Directed evolution of cyclic peptides for inhibition of autophagy JP Gray, MN Uddin, R Chaudhari, MN Sutton, H Yang, P Rask, H Locke, ... Chemical Science 12 (10), 3526-3543, 2021 | 29 | 2021 |
| DIRAS3: an imprinted tumor suppressor gene that regulates RAS and PI3K-driven cancer growth, motility, autophagy, and tumor dormancy G Bildik, X Liang, MN Sutton, RC Bast Jr, Z Lu Molecular cancer therapeutics 21 (1), 25-37, 2022 | 27 | 2022 |
| Induction of autophagy by ARHI (DIRAS3) alters fundamental metabolic pathways in ovarian cancer models A Ornelas, CR McCullough, Z Lu, NM Zacharias, LE Kelderhouse, J Gray, ... BMC cancer 16, 1-18, 2016 | 24 | 2016 |
| Excess exogenous pyruvate inhibits lactate dehydrogenase activity in live cells in an MCT1-dependent manner Y Rao, ST Gammon, MN Sutton, NM Zacharias, P Bhattacharya, ... Journal of Biological Chemistry 297 (1), 2021 | 23 | 2021 |
| Complementary longitudinal serum biomarkers to CA125 for early detection of ovarian cancer AR Simmons, EO Fourkala, A Gentry-Maharaj, A Ryan, MN Sutton, ... Cancer Prevention Research 12 (6), 391-400, 2019 | 23 | 2019 |
| Amino acid deprivation-induced autophagy requires upregulation of DIRAS3 through reduction of E2F1 and E2F4 transcriptional repression MN Sutton, GY Huang, J Zhou, W Mao, R Langley, Z Lu, RC Bast Jr Cancers 11 (5), 603, 2019 | 22 | 2019 |
| Analysis of RAS protein interactions in living cells reveals a mechanism for pan-RAS depletion by membrane-targeted RAS binders YC Li, NK Lytle, ST Gammon, L Wang, TK Hayes, MN Sutton, RC Bast Jr, ... Proceedings of the National Academy of Sciences 117 (22), 12121-12130, 2020 | 18 | 2020 |
| DIRAS3-derived peptide inhibits autophagy in ovarian cancer cells by binding to Beclin1 MN Sutton, GY Huang, X Liang, R Sharma, AS Reger, W Mao, L Pang, ... Cancers 11 (4), 557, 2019 | 17 | 2019 |
| Noise exposure in convertible automobiles AA Mikulec, SB Lukens, LE Jackson, MN Deyoung The Journal of Laryngology & Otology 125 (2), 121-125, 2011 | 10 | 2011 |
| RAS-driven macropinocytosis of albumin or dextran reveals mutation-specific target engagement of RAS p. G12C inhibitor ARS-1620 by NIR-fluorescence imaging MN Sutton, ST Gammon, R Muzzioli, F Pisaneschi, B Radaram, P Yang, ... Molecular imaging and biology 24 (3), 498-509, 2022 | 5 | 2022 |
| IL-8, VEGF and IGF-1 play the important role in ARHI mediated-tumor dormancy in ovarian cancer Z Lu, A Orozco, W Mao, Y Wang, MN Sutton, H Yang, DA Levine, ... Cancer Research 76 (14_Supplement), 1151-1151, 2016 | 3 | 2016 |
| Helical stapled peptides derived from DIRAS3 block KRAS dimerization and downstream MEK/ERK signaling in pancreatic and ovarian carcinomas JP Gray, GE Bildik, MN Sutton, Y Zhou, S Millward, JF Hancock, Z Lu, ... Cancer Research 82 (12_Supplement), 3599-3599, 2022 | 2 | 2022 |
| Facile real time detection of membrane colocalization of RAS superfamily GTPase proteins in living cells YC Li, L Wang, TK Hayes, MN Sutton, RC Bast Jr, F McCormick, CJ Der, ... bioRxiv, 369587, 2018 | 2 | 2018 |
| The Role of the DIRAS Family Members in Regulating Ras Function, Cancer Growth and Autophagy MN Sutton | 2 | 2017 |
