A LUHMES 3D dopaminergic neuronal model for neurotoxicity testing allowing long-term exposure and cellular resilience analysis L Smirnova, G Harris, J Delp, M Valadares, D Pamies, HT Hogberg, ... Archives of toxicology 90, 2725-2743, 2016 | 113 | 2016 |
Canagliflozin mediated dual inhibition of mitochondrial glutamate dehydrogenase and complex I: an off-target adverse effect PF Secker, S Beneke, N Schlichenmaier, J Delp, S Gutbier, M Leist, ... Cell death & disease 9 (2), 226, 2018 | 75 | 2018 |
A high-throughput approach to identify specific neurotoxicants/developmental toxicants in human neuronal cell function assays J Delp, S Gutbier, S Klima, L Hoelting, K Pinto-Gil, JH Hsieh, M Aichem, ... Altex 35 (2), 235, 2018 | 72 | 2018 |
Development of a neurotoxicity assay that is tuned to detect mitochondrial toxicants J Delp, M Funke, F Rudolf, A Cediel, SH Bennekou, W van der Stel, ... Archives of Toxicology 93, 1585-1608, 2019 | 53 | 2019 |
Prevention of neuronal apoptosis by astrocytes through thiol-mediated stress response modulation and accelerated recovery from proteotoxic stress S Gutbier, AS Spreng, J Delp, S Schildknecht, C Karreman, I Suciu, ... Cell Death & Differentiation 25 (12), 2101-2117, 2018 | 51 | 2018 |
Major changes of cell function and toxicant sensitivity in cultured cells undergoing mild, quasi-natural genetic drift S Gutbier, P May, S Berthelot, A Krishna, T Trefzer, M Behbehani, ... Archives of toxicology 92, 3487-3503, 2018 | 46 | 2018 |
Multiparametric assessment of mitochondrial respiratory inhibition in HepG2 and RPTEC/TERT1 cells using a panel of mitochondrial targeting agrochemicals W van der Stel, G Carta, J Eakins, S Darici, J Delp, A Forsby, ... Archives of toxicology 94, 2707-2729, 2020 | 43 | 2020 |
Stage-specific metabolic features of differentiating neurons: implications for toxicant sensitivity J Delp, S Gutbier, M Cerff, C Zasada, S Niedenführ, L Zhao, L Smirnova, ... Toxicology and applied pharmacology 354, 64-80, 2018 | 35 | 2018 |
Neurotoxicity and underlying cellular changes of 21 mitochondrial respiratory chain inhibitors J Delp, A Cediel-Ulloa, I Suciu, P Kranaster, BMA van Vugt-Lussenburg, ... Archives of Toxicology 95, 591-615, 2021 | 34 | 2021 |
Thiazolides promote G1 cell cycle arrest in colorectal cancer cells by targeting the mitochondrial respiratory chain P Ripani, J Delp, K Bode, ME Delgado, L Dietrich, VM Betzler, N Yan, ... Oncogene 39 (11), 2345-2357, 2020 | 29 | 2020 |
Pharmacological LRH-1/Nr5a2 inhibition limits pro-inflammatory cytokine production in macrophages and associated experimental hepatitis J Schwaderer, TS Phan, A Glöckner, J Delp, M Leist, T Brunner, ... Cell death & disease 11 (2), 154, 2020 | 28 | 2020 |
Reductive modification of genetically encoded 3-nitrotyrosine sites in alpha synuclein expressed in E. coli HR Gerding, C Karreman, A Daiber, J Delp, D Hammler, M Mex, ... Redox biology 26, 101251, 2019 | 27 | 2019 |
New approach methods (NAMs) supporting read-across: Two neurotoxicity AOP-based IATA case studies W Van der Stel, G Carta, J Eakins, J Delp, I Suciu, A Forsby, ... ALTEX: Alternatives to Animal Experiments 38 (4), 615-635, 2021 | 20 | 2021 |
Correlation of structural features of novel 1, 2, 3-triazoles with their neurotoxic and tumoricidal properties EM de Souza-Fagundes, J Delp, PHDM Prazeres, LB Marques, ... Chemico-Biological Interactions 291, 253-263, 2018 | 20 | 2018 |
Identification of mitochondrial toxicants by combined in silico and in vitro studies–A structure-based view on the adverse outcome pathway F Troger, J Delp, M Funke, W van der Stel, C Colas, M Leist, ... Computational Toxicology 14, 100123, 2020 | 16 | 2020 |
A quantitative AOP of mitochondrial toxicity based on data from three cell lines C Tebby, W Gao, J Delp, G Carta, W van der Stel, M Leist, P Jennings, ... Toxicology in Vitro 81, 105345, 2022 | 14 | 2022 |
Mapping the cellular response to electron transport chain inhibitors reveals selective signaling networks triggered by mitochondrial perturbation W van der Stel, H Yang, NG Vrijenhoek, JP Schimming, G Callegaro, ... Archives of toxicology 96 (1), 259-285, 2022 | 13 | 2022 |
Shortened derivatives from native antimicrobial peptide LyeTx I: In vitro and in vivo biological activity assessment LL Fuscaldi, JT de Avelar Júnior, DM Dos Santos, D Boff, VLS de Oliveira, ... Experimental Biology and Medicine 246 (4), 414-425, 2021 | 9 | 2021 |
Dynamic metabolic and transcriptional responses of proteasome-inhibited neurons I Suciu, J Delp, S Gutbier, AK Ückert, AS Spreng, P Eberhard, C Karreman, ... Antioxidants 12 (1), 164, 2023 | 6 | 2023 |
Case study on the use of integrated approaches to testing and assessment for mitochondrial complex-iii-mediated neurotoxicity of azoxystrobin-read-across to other strobilurins … SH Bennekou, W van der Stel, G Carta, J Eakins, J Delp, A Forsby, ... Organisation for Economic Co-operation and Development, 2020 | 3 | 2020 |