| 2′-Deoxyadenosine 5′-diphosphoribose is an endogenous TRPM2 superagonist R Fliegert, A Bauche, AM Wolf Pérez, JM Watt, MD Rozewitz, R Winzer, ... Nature chemical biology 13 (9), 1036-1044, 2017 | 82 | 2017 |
| Structure–activity relationship of adenosine 5′-diphosphoribose at the transient receptor potential melastatin 2 (TRPM2) channel: rational design of antagonists C Moreau, T Kirchberger, JM Swarbrick, SJ Bartlett, R Fliegert, T Yorgan, ... Journal of Medicinal Chemistry 56 (24), 10079-10102, 2013 | 72 | 2013 |
| Nicotinic Acid Adenine Dinucleotide Phosphate (NAADP)-mediated Calcium Signaling and Arrhythmias in the Heart Evoked by β-Adrenergic Stimulation*♦ M Nebel, AP Schwoerer, D Warszta, CC Siebrands, AC Limbrock, ... Journal of Biological Chemistry 288 (22), 16017-16030, 2013 | 53 | 2013 |
| Visualizing context-dependent calcium signaling in encephalitogenic T cells in vivo by two-photon microscopy NI Kyratsous, IJ Bauer, G Zhang, M Pesic, I Bartholomäus, M Mues, ... Proceedings of the National Academy of Sciences 114 (31), E6381-E6389, 2017 | 46 | 2017 |
| Direct activation of NADPH oxidase 2 by 2-deoxyribose-1-phosphate triggers nuclear factor kappa B-dependent angiogenesis D Vara, JM Watt, TM Fortunato, H Mellor, M Burgess, K Wicks, K Mace, ... Antioxidants & Redox Signaling 28 (2), 110-130, 2018 | 40 | 2018 |
| Ligand-induced activation of human TRPM2 requires the terminal ribose of ADPR and involves Arg1433 and Tyr1349 R Fliegert, JM Watt, A Schöbel, MD Rozewitz, C Moreau, T Kirchberger, ... Biochemical Journal 474 (13), 2159-2175, 2017 | 39 | 2017 |
| ‘Click cyclic ADP-ribose’: a neutral second messenger mimic JM Swarbrick, R Graeff, C Garnham, MP Thomas, A Galione, BVL Potter Chemical communications 50 (19), 2458-2461, 2014 | 34 | 2014 |
| CD38 Structure-Based Inhibitor Design Using the N1-Cyclic Inosine 5′-Diphosphate Ribose Template C Moreau, Q Liu, R Graeff, GK Wagner, MP Thomas, JM Swarbrick, ... PLoS One 8 (6), e66247, 2013 | 31 | 2013 |
| Total Synthesis of a cyclic adenosine 5′-diphosphate ribose receptor agonist JM Swarbrick, BVL Potter The Journal of organic chemistry 77 (9), 4191-4197, 2012 | 29 | 2012 |
| Cyclic adenosine 5′-diphosphate ribose analogs without a “southern” ribose inhibit ADP-ribosyl cyclase–hydrolase CD38 JM Swarbrick, R Graeff, H Zhang, MP Thomas, Q Hao, BVL Potter Journal of medicinal chemistry 57 (20), 8517-8529, 2014 | 20 | 2014 |
| Different substrate specificities of the two ADPR binding sites in TRPM2 channels of Nematostella vectensis and the role of IDPR FJP Kühn, JM Watt, BVL Potter, A Lückhoff Scientific reports 9 (1), 4985, 2019 | 16 | 2019 |
| Regioselective deprotection of orthobenzoates for the synthesis of inositol phosphates JM Swarbrick, S Cooper, G Bultynck, PRJ Gaffney Organic & Biomolecular Chemistry 7 (8), 1709-1715, 2009 | 16 | 2009 |
| Synthesis of terminal ribose analogues of adenosine 5′-diphosphate ribose as probes for the transient receptor potential cation channel TRPM2 O Baszczyňski, JM Watt, MD Rozewitz, AH Guse, R Fliegert, BVL Potter The Journal of organic chemistry 84 (10), 6143-6157, 2019 | 15 | 2019 |
| Small Molecule Antagonists of NAADP-Induced Ca2+ Release in T-Lymphocytes Suggest Potential Therapeutic Agents for Autoimmune Disease B Zhang, JM Watt, C Cordiglieri, W Dammermann, MF Mahon, A Flügel, ... Scientific Reports 8 (1), 16775, 2018 | 13 | 2018 |
| Synthesis of 4-C-Alkyl Inositol 1,4,5-Trisphosphates and 1,3,4,5-Tetrakisphosphates JM Swarbrick, PRJ Gaffney The Journal of Organic Chemistry 75 (13), 4376-4386, 2010 | 12 | 2010 |
| Synthesis of phosphonoacetate analogues of the second messenger adenosine 5′-diphosphate ribose (ADPR) O Baszczyňski, JM Watt, MD Rozewitz, R Fliegert, AH Guse, BVL Potter RSC advances 10 (3), 1776-1785, 2020 | 9 | 2020 |
| Designer small molecules to target calcium signalling JM Swarbrick, AM Riley, SJ Mills, BVL Potter Biochemical Society Transactions 43 (3), 417-425, 2015 | 9 | 2015 |
| Inositol Adenophostin: Convergent Synthesis of a Potent Agonist of d-myo-Inositol 1,4,5-Trisphosphate Receptors X Su, W Dohle, SJ Mills, JM Watt, AM Rossi, CW Taylor, BVL Potter ACS omega 5 (44), 28793-28811, 2020 | 5 | 2020 |
| Second messenger analogues highlight unexpected substrate sensitivity of CD38: total synthesis of the hybrid “L-cyclic inosine 5′-diphosphate ribose” JM Watt, R Graeff, MP Thomas, BVL Potter Scientific reports 7 (1), 16100, 2017 | 4 | 2017 |
| Synthetic cADPR analogues may form only one of two possible conformational diastereoisomers JM Watt, MP Thomas, BVL Potter Scientific Reports 8 (1), 15268, 2018 | 3 | 2018 |
