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Karan H. Muchhala
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Effects of acute and repeated treatment with the biased mu opioid receptor agonist TRV130 (oliceridine) on measures of antinociception, gastrointestinal function, and abuse …
AA Altarifi, B David, KH Muchhala, BE Blough, H Akbarali, SS Negus
Journal of Psychopharmacology 31 (6), 730-739, 2017
1602017
Chemotherapy induced gastrointestinal toxicities
HI Akbarali, KH Muchhala, DK Jessup, S Cheatham
Advances in cancer research 155, 131-166, 2022
432022
Glycine and GABAA ultra-sensitive ethanol receptors as novel tools for alcohol and brain research
A Naito, KH Muchhala, L Asatryan, JR Trudell, GE Homanics, DI Perkins, ...
Molecular Pharmacology 86 (6), 635-646, 2014
162014
Role of β-arrestin-2 in short-and long-term opioid tolerance in the dorsal root ganglia
KH Muchhala, JC Jacob, WL Dewey, HI Akbarali
European journal of pharmacology 899, 174007, 2021
142021
Sex-specific role for serotonin 5-HT2A receptor in modulation of opioid-induced antinociception and reward in mice
S Sierra, KH Muchhala, DK Jessup, KM Contreras, UH Shah, DL Stevens, ...
Neuropharmacology 209, 108988, 2022
82022
The guts of the opioid crisis
KH Muchhala, JC Jacob, M Kang, WL Dewey, HI Akbarali
Physiology 36 (5), 315-323, 2021
82021
Manipulations of extracellular Loop 2 in α1 GlyR ultra-sensitive ethanol receptors (USERs) enhance receptor sensitivity to isoflurane, ethanol, and lidocaine, but not propofol
A Naito, KH Muchhala, J Trang, L Asatryan, JR Trudell, GE Homanics, ...
Neuroscience 297, 68-77, 2015
82015
The “culture” of pain control: A review of opioid-induced dysbiosis (OID) in antinociceptive tolerance
RA Mischel, KH Muchhala, WL Dewey, HI Akbarali
The Journal of Pain 21 (7-8), 751-762, 2020
62020
The role of morphine-induced impairment of intestinal epithelial antibacterial activity in dysbiosis and its impact on the microbiota-gut-brain axis
K Muchhala, M Kang, E Koseli, J Poklis, Q Xu, W Dewey, J Fettweis, ...
Research Square, 2023
52023
Chronic Morphine Induces IL-18 in Ileum Myenteric Plexus Neurons Through Mu-opioid Receptor Activation in Cholinergic and VIPergic Neurons
KH Muchhala, E Koseli, AR Gade, K Woods, S Minai, M Kang, ...
Journal of Neuroimmune Pharmacology 17 (1), 111-130, 2022
52022
Morphine exacerbates experimental colitis-induced depression of nesting in mice
SM Cheatham, KH Muchhala, E Koseli, JC Jacob, E Komla, SS Negus, ...
Frontiers in Pain Research 2, 738499, 2021
42021
Rapid tolerance to morphine in the myenteric neurons of the small intestine is independent of β-arrestin-2 and mediated by PKC
KH Muchhala, JC Jacob, I Alam, S Hasan, A Khan, M Kang, WL Dewey, ...
BioRxiv, 2020.07. 17.209437, 2020
32020
Mutations In GABAA Receptor Loop 2 Create Ultrasensitive Ethanol Receptors (USERs) Sensitive To Micromolar Ethanol Concentrations
A Naito, K Muchhala, L Asatryan, JR Trudell, GE Homanics, DL Davies, ...
ALCOHOLISM-CLINICAL AND EXPERIMENTAL RESEARCH 37, 242A-242A, 2013
12013
Role of β-arrestin-2 in the development of opioid withdrawal in the mouse colon
S Rehman, S Haider, KH Muchhala, HI Akbarali
Journal of Pharmacology and Experimental Therapeutics 389 (S3), 2024
2024
The role of morphine‐and fentanyl‐induced impairment of intestinal epithelial antibacterial activity in dysbiosis and its impact on the microbiota‐gut‐brain axis
KH Muchhala, PS Kallurkar, M Kang, E Koseli, JL Poklis, Q Xu, WL Dewey, ...
The FASEB Journal 38 (8), e23603, 2024
2024
Endocannabinoid biosynthetic enzymes regulate pain response via LKB1–AMPK signaling
M Chen, M Shin, TB Ware, G Donvito, KH Muchhala, R Mischel, ...
Proceedings of the National Academy of Sciences 120 (52), e2304900120, 2023
2023
Enhanced Cholinergic Action of Myenteric Neurons During Chemotherapy Induced Diarrhea
S Cheatham, KH Muchhala, HI Akbarali
Journal of Pharmacology and Experimental Therapeutics 385 (S3), 2023
2023
Chronic Morphine and Fentanyl Induce Intestinal Dysbiosis by Decreasing the Antimicrobial Activity of the Ileum
KH Muchhala, GK Mahon, E Koseli, J Bethea, M Kang, HI Akbarali
Journal of Pharmacology and Experimental Therapeutics 385 (S3), 368, 2023
2023
O-13: INHIBITION OF THE ENDOCANNABINOID REGULATING ENZYME MONOACYLGLYCEROL LIPASE AMELIORATES THE HYPER-NOCICEPTIVE PHENOTYPE IN THE BERKELEY MOUSE MODEL OF SICKLE CELL DISEASE
K GOLDSBOROUGH, K MUCHHALA, A ADU-GYAMFI, S HERZ, ...
HemaSphere 6, 08, 2022
2022
Distinct Mechanisms of Morphine Tolerance in Enteric Neurons and Dorsal Root Ganglia Neurons: Role of β‐arrestin‐2
KH Muchhala, HI Akbarali
The FASEB Journal 36, 2022
2022
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