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Yang Yu
Yang Yu
Verified email at queensu.ca
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Endosomal signaling of delta opioid receptors is an endogenous mechanism and therapeutic target for relief from inflammatory pain
NN Jimenez-Vargas, J Gong, MJ Wisdom, DD Jensen, R Latorre, ...
Proceedings of the National Academy of Sciences 117 (26), 15281-15292, 2020
852020
Histamine production by the gut microbiota induces visceral hyperalgesia through histamine 4 receptor signaling in mice
G De Palma, C Shimbori, DE Reed, Y Yu, V Rabbia, J Lu, ...
Science Translational Medicine 14 (655), eabj1895, 2022
552022
Interplay between mast cells, enterochromaffin cells, and sensory signaling in the aging human bowel
Y Yu, DM Daly, IJ Adam, P Kitsanta, CJ Hill, J Wild, A Shorthouse, ...
Neurogastroenterology & Motility 28 (10), 1465-1479, 2016
432016
Agonist that activates the µ-opioid receptor in acidified microenvironments inhibits colitis pain without side effects
NN Jiménez-Vargas, Y Yu, DD Jensen, DD Bok, M Wisdom, R Latorre, ...
Gut 71 (4), 695-704, 2022
362022
Deoxycholic acid activates colonic afferent nerves via 5-HT3 receptor-dependent and -independent mechanisms
Y Yu, EC Villalobos-Hernandez, S Pradhananga, CC Baker, C Keating, ...
American Journal of Physiology-Gastrointestinal and Liver Physiology 317 (3 …, 2019
322019
Ageing and gastrointestinal sensory function: altered colonic mechanosensory and chemosensory function in the aged mouse
C Keating, L Nocchi, Y Yu, J Donovan, D Grundy
The Journal of Physiology 594 (16), 4549-4564, 2016
322016
Inducible nitric oxide synthase‐derived nitric oxide reduces vagal satiety signalling in obese mice
Y Yu, SJ Park, MJ Beyak
The Journal of Physiology 597 (6), 1487-1502, 2019
202019
Cannabinoid 1 and mu-opioid receptor agonists synergistically inhibit abdominal pain and lack side effects in mice
Y Yu, QK Tsang, J Jaramillo-Polanco, AE Lomax, SJ Vanner, DE Reed
Journal of Neuroscience 42 (33), 6313-6324, 2022
152022
Increased TASK channel-mediated currents underlie high-fat diet induced vagal afferent dysfunction
SJ Park, Y Yu, B Wagner, WC Valinsky, AE Lomax, MJ Beyak
American Journal of Physiology-Gastrointestinal and Liver Physiology 315 (4 …, 2018
132018
Changes in signalling from faecal neuroactive metabolites following dietary modulation of IBS pain
CJ Tuck, AA Omar, G De Palma, S Osman, NN Jiménez-Vargas, Y Yu, ...
Gut 72 (9), 1678-1691, 2023
112023
Mechanisms of reduced leptin-mediated satiety signaling during obesity
SJ Park, Y Yu, CG Zides, MJ Beyak
International Journal of Obesity 46 (6), 1212-1221, 2022
92022
Dietary monosodium glutamate increases visceral hypersensitivity in a mouse model of visceral pain
BJA Brant, Y Yu, AA Omar, JO Jaramillo Polanco, CD Lopez Lopez, ...
Neurogastroenterology & Motility 35 (9), e14596, 2023
32023
Opioid-induced pronociceptive signaling in the gastrointestinal tract is mediated by delta-opioid receptor signaling
J Jaramillo-Polanco, C Lopez-Lopez, Y Yu, E Neary, A Hegron, M Canals, ...
Journal of Neuroscience 42 (16), 3316-3328, 2022
32022
Effect of high-fat diet on mechanosensitive transient receptor potential channel activation in vagal afferent neurons
SJ Park, Y Yu, MJ Beyak
Canadian Journal of Physiology and Pharmacology 99 (6), 660-666, 2021
32021
916-Gut microbiota-diet interactions in a humanized mouse model of IBS: the role of intestinal mast cells
C Shimbori, G De Palma, DE Reed, M Pigrau, J Lu, Y Zhang, Y Yu, ...
Gastroenterology 154 (6), S-182, 2018
32018
Diet-Microbiota Interactions Underlie Symptoms' Generation in IBS
G De Palma, DE Reed, M Pigrau, J Lu, S Sidani, Y Zhang, Y Yu, ...
Gastroenterology 152 (5), S160, 2017
32017
A124 synergistic interaction of cannabinoids and opioids reduces pain signaling in colonic nociceptive nerves
Q Tsang, Y Yu, AE Lomax, S Vanner, DE Reed
Journal of the Canadian Association of Gastroenterology 3 (Supplement_1 …, 2020
22020
Su1658-Gut Microbiota Defines Host Responses to Dietary Fermentable Carbohydrates in IBS: The Role of Bacterial Histamine
G De Palma, DE Reed, C Shimbori, Y Zhang, M Pigrau, Y Yu, J Lu, ...
Gastroenterology 154 (6), S-565, 2018
22018
Evolving acidic microenvironments during colitis provide selective analgesic targets for a pH-sensitive opioid
CE Degro, NN Jiménez-Vargas, Q Tsang, Y Yu, M Guzman-Rodriguez, ...
Pain, 10.1097, 2022
12022
A53 a novel ph-sensitive opioid analogue provides sustained analgesia during colonic inflammation and lacks common side effects
CE Degro, NN Jiménez-Vargas, QK Tsang, Y Yu, C Stein, NW Bunnett, ...
Journal of the Canadian Association of Gastroenterology 5 (Suppl 1), 61, 2022
12022
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Articles 1–20