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Jacqueto Zephyr
Jacqueto Zephyr
Nimbus Therapeutics
Verified email at nimbustx.com
Title
Cited by
Cited by
Year
Viral proteases: Structure, mechanism and inhibition
J Zephyr, NK Yilmaz, CA Schiffer
The Enzymes 50, 301-333, 2021
462021
Drug design strategies to avoid resistance in direct-acting antivirals and beyond
AN Matthew, F Leidner, GJ Lockbaum, M Henes, J Zephyr, S Hou, ...
Chemical reviews 121 (6), 3238-3270, 2021
432021
Hepatitis C virus NS3/4A protease inhibitors incorporating flexible P2 quinoxalines target drug resistant viral variants
AN Matthew, J Zephyr, CJ Hill, M Jahangir, A Newton, CJ Petropoulos, ...
Journal of medicinal chemistry 60 (13), 5699-5716, 2017
412017
Avoiding drug resistance by substrate envelope-guided design: Toward potent and robust HCV NS3/4A protease inhibitors
AN Matthew, J Zephyr, D Nageswara Rao, M Henes, W Kamran, ...
MBio 11 (2), 10.1128/mbio. 00172-20, 2020
162020
Discovery of quinoxaline-based p1–p3 macrocyclic ns3/4a protease inhibitors with potent activity against drug-resistant hepatitis C virus variants
D Nageswara Rao, J Zephyr, M Henes, ET Chan, AN Matthew, ...
Journal of medicinal chemistry 64 (16), 11972-11989, 2021
112021
Viral proteases: structure, mechanism and inhibition. Enzymes 50: 301-333
J Zephyr, N Kurt Yilmaz, CA Schiffer
82021
Deciphering the molecular mechanism of HCV protease inhibitor Fluorination as a general approach to avoid drug resistance
J Zephyr, DN Rao, SV Vo, M Henes, K Kosovrasti, AN Matthew, ...
Journal of molecular biology 434 (9), 167503, 2022
62022
Avoiding drug resistance by substrate envelope-guided design: toward potent and robust HCV NS3/4A protease inhibitors. mBio 11 (2): e00172-20
AN Matthew, J Zephyr, D Nageswara Rao, M Henes, W Kamran, ...
52020
Allosteric quinoxaline-based inhibitors of the flavivirus NS2B/NS3 protease
J Zephyr, DN Rao, C Johnson, AM Shaqra, EA Nalivaika, A Jordan, ...
Bioorganic chemistry 131, 106269, 2023
32023
FruitFire: a luciferase based on a fruit fly metabolic enzyme
ST Adams Jr, J Zephyr, MF Bohn, CA Schiffer, SC Miller
bioRxiv, 2023
2023
Hepatitis c virus ns3/4a protease inhibitors
CA Schiffer, A Ali, J Zephyr, AN Matthew, NR Desaboini
US Patent App. 17/607,886, 2022
2022
Discovery of Quinoxaline-Based P1-P3 Macrocyclic NS3/4A Protease Inhibitors with Potent Activity against Drug-Resistant Hepatitis C Virus Variants
NR Desaboini, J Zephyr, M Henes, ET Chan, AN Matthew, A Hedger, ...
2021
Robust Drug Design Strategies and Discovery Targeting Viral Proteases
J Zephyr
2021
Avoiding Drug Resistance by Substrate Envelope Guided Design: Toward Potent and Robust HCV NS3/4A Protease Inhibitors
J Zephyr, AN Matthew, DN Rao, M Henes, W Kamran, AK Hedger, ...
The FASEB Journal 34 (S1), 1-1, 2020
2020
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LL Heckert
1976
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Articles 1–15