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Jonathan Cairns
Jonathan Cairns
Unknown affiliation
Verified email at astrazeneca.com
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Cited by
Year
Lineage-specific genome architecture links enhancers and non-coding disease variants to target gene promoters
BM Javierre, OS Burren, SP Wilder, R Kreuzhuber, SM Hill, S Sewitz, ...
Cell 167 (5), 1369-1384. e19, 2016
9652016
CHiCAGO: robust detection of DNA looping interactions in Capture Hi-C data
J Cairns, P Freire-Pritchett, SW Wingett, C Várnai, A Dimond, V Plagnol, ...
Genome biology 17, 1-17, 2016
3932016
Lineage-specific dynamic and pre-established enhancer–promoter contacts cooperate in terminal differentiation
AJ Rubin, BC Barajas, M Furlan-Magaril, V Lopez-Pajares, MR Mumbach, ...
Nature genetics 49 (10), 1522-1528, 2017
2872017
AZD7648 is a potent and selective DNA-PK inhibitor that enhances radiation, chemotherapy and olaparib activity
JHL Fok, A Ramos-Montoya, M Vazquez-Chantada, PWG Wijnhoven, ...
Nature communications 10 (1), 5065, 2019
2312019
Dynamic rewiring of promoter-anchored chromatin loops during adipocyte differentiation
R Siersbæk, JGS Madsen, BM Javierre, R Nielsen, EK Bagge, J Cairns, ...
Molecular cell 66 (3), 420-435. e5, 2017
2052017
Global reorganisation of cis-regulatory units upon lineage commitment of human embryonic stem cells
P Freire-Pritchett, S Schoenfelder, C Várnai, SW Wingett, J Cairns, ...
Elife 6, e21926, 2017
1522017
Long-range enhancer interactions are prevalent in mouse embryonic stem cells and are reorganized upon pluripotent state transition
CL Novo, BM Javierre, J Cairns, A Segonds-Pichon, SW Wingett, ...
Cell reports 22 (10), 2615-2627, 2018
1032018
Integrated in vitro models for hepatic safety and metabolism: evaluation of a human Liver-Chip and liver spheroid
AJ Foster, B Chouhan, SL Regan, H Rollison, S Amberntsson, ...
Archives of toxicology 93 (4), 1021-1037, 2019
892019
Chromosome contacts in activated T cells identify autoimmune disease candidate genes
OS Burren, A Rubio García, BM Javierre, DB Rainbow, J Cairns, ...
Genome biology 18, 1-19, 2017
852017
BASH: a tool for managing BeadArray spatial artefacts
JM Cairns, MJ Dunning, ME Ritchie, R Russell, AG Lynch
Bioinformatics 24 (24), 2921-2922, 2008
822008
Platelet function is modified by common sequence variation in megakaryocyte super enhancers
R Petersen, JJ Lambourne, BM Javierre, L Grassi, R Kreuzhuber, ...
Nature communications 8 (1), 16058, 2017
622017
Phenotype specific analyses reveal distinct regulatory mechanism for chronically activated p53
K Kirschner, SA Samarajiwa, JM Cairns, S Menon, PA Pérez-Mancera, ...
PLoS genetics 11 (3), e1005053, 2015
622015
BayesPeak—an R package for analysing ChIP-seq data
J Cairns, C Spyrou, R Stark, ML Smith, AG Lynch, S Tavaré
Bioinformatics 27 (5), 713-714, 2011
542011
The global and promoter-centric 3D genome organization temporally resolved during a circadian cycle
M Furlan-Magaril, M Ando-Kuri, RG Arzate-Mejía, J Morf, J Cairns, ...
Genome biology 22 (1), 162, 2021
282021
RNA proximity sequencing reveals the spatial organization of the transcriptome in the nucleus
J Morf, SW Wingett, I Farabella, J Cairns, M Furlan-Magaril, ...
Nature biotechnology 37 (7), 793-802, 2019
282019
Chicdiff: a computational pipeline for detecting differential chromosomal interactions in Capture Hi-C data
J Cairns, WR Orchard, V Malysheva, M Spivakov
Bioinformatics 35 (22), 4764-4766, 2019
242019
Single‐cell study of neural stem cells derived from human iPSCs reveals distinct progenitor populations with neurogenic and gliogenic potential
M Lam, T Sanosaka, A Lundin, K Imaizumi, D Etal, FH Karlsson, ...
Genes to Cells 24 (12), 836-847, 2019
222019
Detecting chromosomal interactions in Capture Hi-C data with CHiCAGO and companion tools
P Freire-Pritchett, H Ray-Jones, M Della Rosa, CQ Eijsbouts, WR Orchard, ...
Nature protocols 16 (9), 4144-4176, 2021
212021
Consortium B, Stunnenberg HG, Todd JA, Zerbino DR, Stegle O, Ouwehand WH, Frontini M, Wallace C, Spivakov M, Fraser P. Lineage-specific genome architecture links enhancers and …
BM Javierre, OS Burren, SP Wilder, R Kreuzhuber, SM Hill, S Sewitz, ...
Cell 167 (5), 1369-138419, 2016
152016
Radiopotentiation profiling of multiple inhibitors of the DNA damage response for early clinical development
SJ Gill, PWG Wijnhoven, JHL Fok, RL Lloyd, J Cairns, J Armenia, J Nikkilä, ...
Molecular cancer therapeutics 20 (9), 1614-1626, 2021
132021
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