| Retinoic acid receptor-related orphan receptor gamma-t (RORγt) inhibitors in clinical development for the treatment of autoimmune diseases: a patent review (2016-present) N Sun, H Guo, Y Wang Expert Opinion on Therapeutic Patents 29 (9), 663-674, 2019 | 66 | 2019 |
| In Vivo Imaging of Senescent Vascular Cells in Atherosclerotic Mice Using a β-Galactosidase-Activatable Nanoprobe JA Chen, W Guo, Z Wang, N Sun, H Pan, J Tan, Z Ouyang, W Fu, Y Wang, ... Analytical Chemistry 92 (18), 12613-12621, 2020 | 37 | 2020 |
| Discovery of novel BTK PROTACs for B-Cell lymphomas Y Zhao, Y Shu, J Lin, Z Chen, Q Xie, Y Bao, L Lu, N Sun, Y Wang European Journal of Medicinal Chemistry 225, 113820, 2021 | 28 | 2021 |
| Discovery of carbazole carboxamides as novel RORγt inverse agonists Y Huang, M Yu, N Sun, T Tang, F Yu, X Song, Q Xie, W Fu, L Shao, ... European Journal of Medicinal Chemistry 148, 465-476, 2018 | 24 | 2018 |
| Agonist lock touched and untouched retinoic acid receptor-related orphan receptor-γt (RORγt) inverse agonists: classification based on the molecular mechanisms of action N Sun, Q Xie, Y Dang, Y Wang Journal of Medicinal Chemistry 64 (15), 10519-10536, 2021 | 20 | 2021 |
| Molecular mechanism of action of RORγt agonists and inverse agonists: Insights from molecular dynamics simulation N Sun, C Yuan, X Ma, Y Wang, X Gu, W Fu Molecules 23 (12), 3181, 2018 | 19 | 2018 |
| Discovery of N-indanyl benzamides as potent RORγt inverse agonists J Tian, N Sun, M Yu, X Gu, Q Xie, L Shao, J Liu, L Liu, Y Wang European Journal of Medicinal Chemistry 167, 37-48, 2019 | 18 | 2019 |
| Discovery of aryl-substituted indole and indoline derivatives as RORγt agonists Y Zhu, N Sun, M Yu, H Guo, Q Xie, Y Wang European Journal of Medicinal Chemistry 182, 111589, 2019 | 14 | 2019 |
| Discovery of novel N-sulfonamide-tetrahydroisoquinolines as potent retinoic acid receptor-related orphan receptor γt agonists X Ma, N Sun, X Li, W Fu European Journal of Medicinal Chemistry 222, 113585, 2021 | 11 | 2021 |
| Discovery of tetrahydroquinolines and benzomorpholines as novel potent RORγt agonists Y Xia, M Yu, Y Zhao, L Xia, Y Huang, N Sun, M Song, H Guo, Y Zhang, ... European Journal of Medicinal Chemistry 211, 113013, 2021 | 10 | 2021 |
| Discovery of carboxyl-containing biaryl ureas as potent RORγt inverse agonists N Sun, Y Huang, M Yu, Y Zhao, JA Chen, C Zhu, M Song, H Guo, Q Xie, ... European Journal of Medicinal Chemistry 202, 112536, 2020 | 9 | 2020 |
| Discovery of novel N-sulfonamide-tetrahydroquinolines as potent retinoic acid receptor-related orphan receptor γt inverse agonists for the treatment of autoimmune diseases N Sun, X Ma, K Zhou, C Zhu, Z Cao, Y Wang, J Xu, W Fu European Journal of Medicinal Chemistry 187, 111984, 2020 | 9 | 2020 |
| Molecular dynamics simulations on RORγt: insights into its functional agonism and inverse agonism C Yuan, H Chen, N Sun, X Ma, J Xu, W Fu Acta Pharmacologica Sinica 40 (11), 1480-1489, 2019 | 9 | 2019 |
| Crystallography-guided discovery of carbazole-based retinoic acid-related orphan receptor gamma-t (RORγt) modulators: insights into different protein behaviors with “short” and … M Yu, F Yang, X Ding, N Sun, Z Jiang, Y Huang, Y Yan, C Zhu, Q Xie, ... Acta Pharmacologica Sinica 42 (9), 1524-1534, 2021 | 6 | 2021 |
| Ontogeny of RORγt+ cells in the intestine of newborns and its role in the development of experimental necrotizing enterocolitis X Zhao, W Liang, Y Wang, R Yi, L Luo, W Wang, N Sun, M Yu, W Xu, ... Cell & Bioscience 12 (1), 3, 2022 | 5 | 2022 |
| Development and therapeutic potential of allosteric retinoic acid receptor-related orphan receptor γt (RORγt) inverse agonists for autoimmune diseases L Lu, N Sun, Y Wang European Journal of Medicinal Chemistry, 115574, 2023 | 3 | 2023 |
| Optimization of carbazole carboxamide RORγt agonists: Challenges in improving the metabolic stability and maintaining the agonistic activity N Sun, M Yu, Z Jiang, F Yang, L Lu, Y Xia, Y Zhao, Y Huang, S Chen, ... European Journal of Medicinal Chemistry 251, 115213, 2023 | 2 | 2023 |
| Discovery of Biaryl Amide Derivatives as Potent, Selective, and Orally Bioavailable RORγt Agonists for Cancer Immunotherapy L Lu, Y Huang, M Song, N Sun, L Xia, M Yu, M Zhao, R Qiu, J Chen, ... Journal of Medicinal Chemistry 66 (23), 16091-16108, 2023 | | 2023 |
| Modes of action insights from the crystallographic structures of retinoic acid receptor-related orphan receptor-γt (RORγt) J Zhang, B Chen, C Zhang, N Sun, X Huang, W Wang, W Fu European Journal of Medicinal Chemistry 247, 115039, 2023 | | 2023 |
| Discovery of carbazole carboxamides as novel ROR gamma t agonists M Yu, N Sun, Y Huang, Y Yan, C Zhu, Q Xie, Y Wang Abstracts of Papers of the American Chemical Society 258, 2019 | | 2019 |
