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| First selective 12-LOX inhibitor, ML355, impairs thrombus formation and vessel occlusion in vivo with minimal effects on hemostasis R Adili, BE Tourdot, K Mast, J Yeung, JC Freedman, A Green, DK Luci, ... Arteriosclerosis, thrombosis, and vascular biology 37 (10), 1828-1839, 2017 | 95 | 2017 |
| 12(S)-HETrE, a 12-Lipoxygenase Oxylipin of Dihomo-γ-Linolenic Acid, Inhibits Thrombosis via Gαs Signaling in Platelets J Yeung, BE Tourdot, R Adili, AR Green, CJ Freedman, ... Arteriosclerosis, thrombosis, and vascular biology 36 (10), 2068-2077, 2016 | 75 | 2016 |
| 15-Lipoxygenase-1 biosynthesis of 7S, 14S-diHDHA implicates 15-lipoxygenase-2 in biosynthesis of resolvin D5 [S] SC Perry, C Kalyanaraman, BE Tourdot, WS Conrad, O Akinkugbe, ... Journal of lipid research 61 (7), 1087-1103, 2020 | 44 | 2020 |
| Biochemical and Cellular Characterization and Inhibitor Discovery of Pseudomonas aeruginosa 15-Lipoxygenase JD Deschamps, AF Ogunsola, JB Jameson, A Yasgar, BA Flitter, ... Biochemistry 55 (23), 3329-3340, 2016 | 40 | 2016 |
| 12-HETrE inhibits platelet reactivity and thrombosis in part through the prostacyclin receptor BE Tourdot, R Adili, ZR Isingizwe, M Ebrahem, JC Freedman, TR Holman, ... Blood advances 1 (15), 1124-1131, 2017 | 32 | 2017 |
| 5S,15S-Dihydroperoxyeicosatetraenoic Acid (5,15-diHpETE) as a Lipoxin Intermediate: Reactivity and Kinetics with Human Leukocyte 5-Lipoxygenase, Platelet 12 … AR Green, C Freedman, J Tena, BE Tourdot, B Liu, M Holinstat, ... Biochemistry 57 (48), 6726-6734, 2018 | 31 | 2018 |
| Biosynthesis of the maresin intermediate, 13S, 14S-Epoxy-DHA, by human 15-lipoxygenase and 12-lipoxygenase and its regulation through negative allosteric modulators C Freedman, A Tran, BE Tourdot, C Kalyanaraman, S Perry, M Holinstat, ... Biochemistry 59 (19), 1832-1844, 2020 | 29 | 2020 |
| DHA 12‐LOX‐derived oxylipins regulate platelet activation and thrombus formation through a PKA‐dependent signaling pathway A Yamaguchi, L Stanger, CJ Freedman, M Standley, T Hoang, R Adili, ... Journal of Thrombosis and Haemostasis 19 (3), 839-851, 2021 | 25 | 2021 |
| Omega-6 DPA and its 12-lipoxygenase–oxidized lipids regulate platelet reactivity in a nongenomic PPARα-dependent manner J Yeung, R Adili, A Yamaguchi, CJ Freedman, A Chen, R Shami, A Das, ... Blood advances 4 (18), 4522-4537, 2020 | 18 | 2020 |
| A potent and selective inhibitor targeting human and murine 12/15-LOX MM Armstrong, CJ Freedman, JE Jung, Y Zheng, C Kalyanaraman, ... Bioorganic & medicinal chemistry 24 (6), 1183-1190, 2016 | 17 | 2016 |
| Human 15-LOX-1 active site mutations alter inhibitor binding and decrease potency M Armstrong, C van Hoorebeke, T Horn, J Deschamps, JC Freedman, ... Bioorganic & medicinal chemistry 24 (21), 5380-5387, 2016 | 7 | 2016 |
| Supplementation with omega‐3 or omega‐6 fatty acids attenuates platelet reactivity in postmenopausal women A Yamaguchi, L Stanger, JC Freedman, A Prieur, R Thav, J Tena, ... Clinical and Translational Science 15 (10), 2378-2391, 2022 | 6 | 2022 |
| Fatty acids negatively regulate platelet function through formation of noncanonical 15‐lipoxygenase‐derived eicosanoids A Yamaguchi, C van Hoorebeke, BE Tourdot, SC Perry, G Lee, N Rhoads, ... Pharmacology Research & Perspectives 11 (1), e01056, 2023 | 3 | 2023 |
| Investigations Into Human Lipoxygenase Biosynthesis of Oxylipins, Their Roles in Inflammation, and Drug Discovery JC Freedman UC Santa Cruz, 2019 | 1 | 2019 |
| 207 Omega-3 and omega-6 fatty acids attenuate platelet reactivity in postmenopausal women A Yamaguchi, L Stanger, A Prieur, R Tav, C Freedman, TR Holman, ... Journal of Clinical and Translational Science 6 (s1), 31-32, 2022 | | 2022 |
| Altered specificity of 15-LOX-1 in the biosynthesis of 7S, 14S-diHDHA implicates 15-LOX-2 in biosynthesis of resolvin D5 SC Perry, C Kalyanaraman, BE Tourdot, WS Conrad, O Akinkugbe, ... bioRxiv, 2020.03. 25.008573, 2020 | | 2020 |
| The Antithrombotic Effects of 12‐LOX Derived Metabolites of DPA, ω‐6 A Chen, J Yeung, A Szatkowski, M Jackson, J Watson, C Freedman, ... The FASEB Journal 32, 571.5-571.5, 2018 | | 2018 |
| 12 (S)-HETrE, a 12-Lipoxygenase Oxylipin of Dihomo-γ-Linolenic Acid, Inhibits Thrombosis via Gα J Yeung, BE Tourdot, R Adili, AR Green, CJ Freedman, ... | | 2016 |
| Biochemical and Cellular Characterization and Inhibitor Discovery of Pseudomonas aeruginosa 15-Lipoxygenase CJ Freedman, JA Melvin, JVMH Nguyen, DJ Maloney, A Jadhav, ... | | |
