| Mammalian target of rapamycin up-regulation of pyruvate kinase isoenzyme type M2 is critical for aerobic glycolysis and tumor growth Q Sun, X Chen, J Ma, H Peng, F Wang, X Zha, Y Wang, Y Jing, H Yang, ... Proceedings of the National Academy of Sciences 108 (10), 4129-4134, 2011 | 651 | 2011 |
| Regulable neural progenitor-specific Tsc1 loss yields giant cells with organellar dysfunction in a model of tuberous sclerosis complex J Goto, DM Talos, P Klein, W Qin, YI Chekaluk, S Anderl, IA Malinowska, ... Proceedings of the National Academy of Sciences 108 (45), E1070-E1079, 2011 | 185 | 2011 |
| NR2B tyrosine phosphorylation modulates fear learning as well as amygdaloid synaptic plasticity T Nakazawa, S Komai, AM Watabe, Y Kiyama, M Fukaya, ... The EMBO journal 25 (12), 2867-2877, 2006 | 166 | 2006 |
| Exome sequencing implicates genetic disruption of prenatal neuro-gliogenesis in sporadic congenital hydrocephalus SC Jin, W Dong, AJ Kundishora, S Panchagnula, A Moreno-De-Luca, ... Nature medicine 26 (11), 1754-1765, 2020 | 106 | 2020 |
| Neuronal Tsc1/2 complex controls autophagy through AMPK-dependent regulation of ULK1 A Di Nardo, MH Wertz, E Kwiatkowski, PT Tsai, JD Leech, ... Human molecular genetics 23 (14), 3865-3874, 2014 | 105 | 2014 |
| Therapeutic value of prenatal rapamycin treatment in a mouse brain model of tuberous sclerosis complex S Anderl, M Freeland, DJ Kwiatkowski, J Goto Human molecular genetics 20 (23), 4597-4604, 2011 | 85 | 2011 |
| A mutation in Ccdc39 causes neonatal hydrocephalus with abnormal motile cilia development in mice Z Abdelhamed, SM Vuong, L Hill, C Shula, A Timms, D Beier, K Campbell, ... Development 145 (1), dev154500, 2018 | 67 | 2018 |
| Loss of Fyn tyrosine kinase on the C57BL/6 genetic background causes hydrocephalus with defects in oligodendrocyte development J Goto, T Tezuka, T Nakazawa, H Sagara, T Yamamoto Molecular and Cellular Neuroscience 38 (2), 203-212, 2008 | 66 | 2008 |
| Smooth muscle protein-22-mediated deletion of Tsc1 results in cardiac hypertrophy that is mTORC1-mediated and reversed by rapamycin AJ Malhowski, H Hira, S Bashiruddin, R Warburton, J Goto, B Robert, ... Human molecular genetics 20 (7), 1290-1305, 2011 | 56 | 2011 |
| Impaired neurogenesis alters brain biomechanics in a neuroprogenitor-based genetic subtype of congenital hydrocephalus PQ Duy, SC Weise, C Marini, XJ Li, D Liang, PJ Dahl, S Ma, A Spajic, ... Nature neuroscience 25 (4), 458-473, 2022 | 54 | 2022 |
| TSC1 loss synergizes with KRAS activation in lung cancer development in the mouse and confers rapamycin sensitivity MC Liang, J Ma, L Chen, P Kozlowski, W Qin, D Li, J Goto, T Shimamura, ... Oncogene 29 (11), 1588-1597, 2010 | 52 | 2010 |
| Prenatal rapamycin results in early and late behavioral abnormalities in wildtype C57BL/6 mice PT Tsai, E Greene-Colozzi, J Goto, S Anderl, DJ Kwiatkowski, M Sahin Behavior genetics 43, 51-59, 2013 | 47 | 2013 |
| Brain-expressed X-linked 2 is pivotal for hyperactive mechanistic target of rapamycin (mTOR)-mediated tumorigenesis Z Hu, Y Wang, F Huang, R Chen, C Li, F Wang, J Goto, DJ Kwiatkowski, ... Journal of Biological Chemistry 290 (42), 25756-25765, 2015 | 40 | 2015 |
| A hypomorphic allele of Tsc2 highlights the role of TSC1/TSC2 in signaling to AKT and models mild human TSC2 alleles K Pollizzi, I Malinowska-Kolodziej, C Doughty, C Betz, J Ma, J Goto, ... Human molecular genetics 18 (13), 2378-2387, 2009 | 37 | 2009 |
| Essential hydrophilic carboxyl-terminal regions including cysteine residues of the yeast stretch-activated calcium-permeable channel Mid1 T Maruoka, Y Nagasoe, S Inoue, Y Mori, J Goto, M Ikeda, H Iida Journal of Biological Chemistry 277 (14), 11645-11652, 2002 | 25 | 2002 |
| Impaired neural differentiation and glymphatic CSF flow in the Ccdc39 rat model of neonatal hydrocephalus: genetic interaction with L1cam AS Emmert, E Iwasawa, C Shula, P Schultz, D Lindquist, RS Dunn, ... Disease Models & Mechanisms 12 (11), dmm040972, 2019 | 22 | 2019 |
| Survival benefit and phenotypic improvement by hamartin gene therapy in a tuberous sclerosis mouse brain model S Prabhakar, X Zhang, J Goto, S Han, C Lai, R Bronson, M Sena-Esteves, ... Neurobiology of disease 82, 22-31, 2015 | 19 | 2015 |
| Neonatal hydrocephalus leads to white matter neuroinflammation and injury in the corpus callosum of Ccdc39 hydrocephalic mice DS Goulding, RC Vogel, CD Pandya, C Shula, JC Gensel, FT Mangano, ... Journal of Neurosurgery: Pediatrics 25 (5), 476-483, 2020 | 18 | 2020 |
| Stochastic Model of Tsc1 Lesions in Mouse Brain S Prabhakar, J Goto, X Zuang, M Sena-Esteves, R Bronson, J Brockmann, ... PLoS One 8 (5), e64224, 2013 | 17 | 2013 |
| Diphtheria toxin induced but not CSF1R inhibitor mediated microglia ablation model leads to the loss of CSF/ventricular spaces in vivo that is independent of cytokine upregulation A Bedolla, A Taranov, F Luo, J Wang, F Turcato, EM Fugate, NH Greig, ... Journal of Neuroinflammation 19 (1), 3, 2022 | 16 | 2022 |
David J. KwiatkowskiProfessor of Medicine, Harvard Medical SchoolVerified email at rics.bwh.harvard.edu
