| Synthesis and biological evaluation of pyrrole-based chalcones as CYP1 enzyme inhibitors, for possible prevention of cancer and overcoming cisplatin resistance IS Williams, P Joshi, L Gatchie, M Sharma, NK Satti, RA Vishwakarma, ... Bioorganic & Medicinal Chemistry Letters 27 (16), 3683-3687, 2017 | 51 | 2017 |
| Discovery and characterization of novel CYP1B1 inhibitors based on heterocyclic chalcones: Overcoming cisplatin resistance in CYP1B1-overexpressing lines NJ Horley, KJM Beresford, T Chawla, GJP McCann, KC Ruparelia, ... European journal of medicinal chemistry 129, 159-174, 2017 | 47 | 2017 |
| Glycyrrhiza glabra extract and quercetin reverses cisplatin resistance in triple-negative MDA-MB-468 breast cancer cells via inhibition of cytochrome P450 1B1 enzyme R Sharma, L Gatchie, IS Williams, SK Jain, RA Vishwakarma, ... Bioorganic & medicinal chemistry letters 27 (24), 5400-5403, 2017 | 43 | 2017 |
| Biphenyl urea derivatives as selective CYP1B1 inhibitors MUM Siddique, GJP McCann, V Sonawane, N Horley, IS Williams, ... Organic & Biomolecular Chemistry 14 (38), 8931-8936, 2016 | 25 | 2016 |
| Furanoflavones pongapin and lanceolatin B blocks the cell cycle and induce senescence in CYP1A1-overexpressing breast cancer cells R Sharma, IS Williams, L Gatchie, VR Sonawane, B Chaudhuri, ... Bioorganic & Medicinal Chemistry 26 (23-24), 6076-6086, 2018 | 18 | 2018 |
| Identification of karanjin isolated from the Indian beech tree as a potent CYP1 enzyme inhibitor with cellular efficacy via screening of a natural product repository P Joshi, VR Sonawane, IS Williams, GJP McCann, L Gatchie, R Sharma, ... Medchemcomm 9 (2), 371-382, 2018 | 18 | 2018 |
| Biotransformation, Using Recombinant CYP450-Expressing Baker’s Yeast Cells, Identifies a Novel CYP2D6.10A122V Variant Which Is a Superior Metabolizer of … IS Williams, L Gatchie, SB Bharate, B Chaudhuri ACS omega 3 (8), 8903-8912, 2018 | 17 | 2018 |
| (E)-3-(3, 4, 5-Trimethoxyphenyl)-1-(pyridin-4-yl) prop-2-en-1-one, a heterocyclic chalcone is a potent and selective CYP1A1 inhibitor and cancer chemopreventive agent NJ Horley, KJM Beresford, S Kaduskar, P Joshi, GJP McCann, ... Bioorganic & Medicinal Chemistry Letters 27 (24), 5409-5414, 2017 | 14 | 2017 |
| Biotransformation of chrysin to baicalein: selective C6-hydroxylation of 5, 7-dihydroxyflavone using whole yeast cells stably expressing human CYP1A1 enzyme IS Williams, S Chib, VK Nuthakki, L Gatchie, P Joshi, NA Narkhede, ... Journal of agricultural and food chemistry 65 (34), 7440-7446, 2017 | 14 | 2017 |
| CYP enzymes, expressed within live human suspension cells, are superior to widely-used microsomal enzymes in identifying potent CYP1A1/CYP1B1 inhibitors: Identification of … VR Sonawane, MUM Siddique, L Gatchie, IS Williams, SB Bharate, ... European Journal of Pharmaceutical Sciences 131, 177-194, 2019 | 13 | 2019 |
| Nonantioxidant tetramethoxystilbene abrogates α-synuclein-induced yeast cell death but not that triggered by the Bax or βA4 peptide A Derf, R Mudududdla, D Akintade, IS Williams, M Abdullaha, ... ACS omega 3 (8), 9513-9532, 2018 | 13 | 2018 |
| Khellinoflavanone, a Semisynthetic Derivative of Khellin, Overcomes Benzo[a]pyrene Toxicity in Human Normal and Cancer Cells That Express CYP1A1 R Sharma, IS Williams, L Gatchie, VR Sonawane, B Chaudhuri, ... ACS omega 3 (8), 8553-8566, 2018 | 13 | 2018 |
| A non-faradaic impedimetric biosensor for monitoring of caspase 9 in mammalian cell culture B Chen, J Kiely, I Williams, R Luxton Bioelectrochemistry 153, 108456, 2023 | 5 | 2023 |
| FUEL GAS PLANTS FOR PROCESS INDUSTRIES BURN COAL CLEANLY, EFFICIENTLY I WILLIAMs Process Engineering, 52-&, 1974 | 1 | 1974 |
| A propofol sensor D Ferrier, I Williams, J Kiely, R Luxton, M O’connell US Patent App. 17/927,209, 2023 | | 2023 |
| A propofol sensor D Ferrier, I WILLIAMS, J Kiely, R Luxton, M O'connell | | 2021 |
| yl) prop-2-en-1-one, a heterocyclic chalcone is a potent and selective CYP1A1 inhibitor and cancer chemopreventive agent NJ Horley, KJM Beresford, S Kaduskar, P Joshi, GJP McCann, ... | | 2017 |
| Glycyrrhiza glabra extract and quercetin reverses cisplatin resistance in triple-negative MDA-MB-468 breast cancer cells via inhibition of cytochrome P450 1B1 … RS Rajni Sharma, L Gatchie, IS Williams, SK Jain, RA Vishwakarma, ... | | 2017 |
| Developing novel systems for expression of intracellular membrane-bound human cytochrome P450 enzymes in baker's yeast IS Williams De Montfort University, 2017 | | 2017 |
| Article a Non-Faradaic Impedimetric Biosensor for Monitoring of Caspase 9 in Mammalian Cell Culture B Chen, J Kiely, R Luxton, I Williams Available at SSRN 4070649, 0 | | |
VINAY SONAWANEEarly Career Research Fellow in Molecular Medicine, De Montfort UniversityVerified email at dmu.ac.uk
