A novel humanized mouse model of Huntington disease for preclinical development of therapeutics targeting mutant huntingtin alleles AL Southwell, NH Skotte, EB Villanueva, ME Østergaard, X Gu, ... Human Molecular Genetics 26 (6), 1115-1132, 2017 | 37 | 2017 |
Human pluripotent stem cells to model islet defects in diabetes D Balboa, DG Iworima, TJ Kieffer Frontiers in Endocrinology 12, 642152, 2021 | 35 | 2021 |
Kif5 regulates mitochondrial movement, morphology, function and neuronal survival DG Iworima, BA Pasqualotto, GL Rintoul Molecular and Cellular Neuroscience 72, 22-33, 2016 | 23 | 2016 |
Augmented two-dimensional correlation spectroscopy for the joint analysis of correlated changes in spectroscopic and disparate sources HG Schulze, S Rangan, MZ Vardaki, DG Iworima, TJ Kieffer, MW Blades, ... Applied Spectroscopy 75 (5), 520-530, 2021 | 10 | 2021 |
Process parameter development for the scaled generation of stem cell-derived pancreatic endocrine cells DG Iworima, S Rieck, TJ Kieffer Stem Cells Translational Medicine 10 (11), 1459-1469, 2021 | 5 | 2021 |
Protocol development to further differentiate and transition stem cell-derived pancreatic progenitors from a monolayer into endocrine cells in suspension culture MJS Braam, J Zhao, S Liang, S Ida, NK Kloostra, DG Iworima, M Tang, ... Scientific Reports 13 (1), 8877, 2023 | 3 | 2023 |
The impact of different implantation sites and sex on the differentiation of human pancreatic endoderm cells into insulin-secreting cells in vivo N Saber, CE Ellis, DG Iworima, RK Baker, A Rezania, TJ Kieffer Diabetes 72 (5), 590-598, 2023 | 3 | 2023 |
Metabolic switching, growth kinetics and cell yields in the scalable manufacture of stem cell-derived insulin-producing cells DG Iworima, RK Baker, C Ellis, C Sherwood, L Zhan, A Rezania, JM Piret, ... Stem Cell Research & Therapy 15 (1), 1, 2024 | 1 | 2024 |
Process Development and Manufacturing: CELL THERAPY MANUFACTURING PROCESS ANALYTICAL UTILITY OF RAMAN SPECTROSCOPY J Piret, HG Schulze, S Rangan, M Vardaki, KN MacDonald, D Iworima, ... Cytotherapy 25 (6), S199, 2023 | 1 | 2023 |
Analysis of the effects of bench-scale cell culture platforms and inoculum cell concentrations on PSC aggregate formation and culture DG Iworima, RK Baker, JM Piret, TJ Kieffer Frontiers in Bioengineering and Biotechnology 11, 2023 | 1 | 2023 |
IDENTIFYING CRITICAL PROCESS PARAMETERS AND CRITICAL QUALITY ATTRIBUTES ASSOCIATED WITH SCALABLE MANUFACTURE OF STEM CELL-DERIVED PANCREATIC ENDOCRINE CELL TYPES DG Iworima, RK Baker, CE Ellis, C Sherwood, L Zhan, J Piret, TJ Kieffer Cytotherapy 26 (6), S111, 2024 | | 2024 |
Differentiation of Human Pluripotent Stem Cells into Insulin-Producing Islet Clusters J Zhao, S Liang, MJS Braam, RK Baker, DG Iworima, N Quiskamp, ... JoVE (Journal of Visualized Experiments), e64840, 2023 | | 2023 |
Process analytical utility of Raman spectroscopy for cell therapy manufacturing J Piret, HG Schulze, S Rangan, MZ Vardaki, K MacDonald, DG Iworima, ... | | 2023 |
Evaluation of Tavakol et al.: Harnessing organs-on-a-chip to model tissue regeneration S Abbasi, A Adoungotchodo, U Ansari, M Baghdadi, K Baral, O Bashth, ... Cell Stem Cell 28 (6), 979-982, 2021 | | 2021 |
Disruption of Kif5c mediated movement affects mitochondrial form, function and cellular health in rat primary cortical neurons and astrocytes DG Iworima Simon Fraser University, 2013 | | 2013 |
Kif5c mediated mitochondrial trafficking affects mitochondrial morphology and function in rat primary cortical neurons D Iworima, G Rintoul MOLECULAR BIOLOGY OF THE CELL 24, 2013 | | 2013 |