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Timothy R. Baffi
Timothy R. Baffi
Senior Scientist, Pfizer
Verified email at pfizer.com - Homepage
Title
Cited by
Cited by
Year
mTORC2 controls the activity of PKC and Akt by phosphorylating a conserved TOR interaction motif
TR Baffi, G Lordén, JM Wozniak, A Feichtner, W Yeung, AP Kornev, ...
Science signaling 14 (678), eabe4509, 2021
742021
Protein Kinase C Quality Control by Phosphatase PHLPP1 Unveils Loss-of-Function Mechanism in Cancer
TR Baffi, AAN Van, W Zhao, GB Mills, AC Newton
Molecular cell 74 (2), 378-392, 2019
492019
KinView: a visual comparative sequence analysis tool for integrated kinome research
DI McSkimming, S Dastgheib, TR Baffi, DP Byrne, S Ferries, ST Scott, ...
Molecular bioSystems 12 (12), 3651-3665, 2016
462016
Integrative annotation and knowledge discovery of kinase post-translational modifications and cancer-associated mutations through federated protein ontologies and resources
LC Huang, KE Ross, TR Baffi, H Drabkin, KJ Kochut, Z Ruan, ...
Scientific reports 8 (1), 6518, 2018
282018
Protein kinase C fusion proteins are paradoxically loss of function in cancer
AAN Van, MT Kunkel, TR Baffi, G Lordén, CE Antal, S Banerjee, ...
Journal of Biological Chemistry 296, 2021
242021
PHLPPing the Script: Emerging Roles of PHLPP Phosphatases in Cell Signaling
TR Baffi, K Cohen-Katsenelson, AC Newton
Annual Review of Pharmacology and Toxicology 61, 723-43, 2021
162021
mTOR regulation of AGC kinases: new twist to an old tail
TR Baffi, AC Newton
Molecular Pharmacology 101 (4), 213-218, 2022
142022
Protein kinase C: release from quarantine by mTORC2
TR Baffi, AC Newton
Trends in biochemical sciences 47 (6), 518-530, 2022
122022
Mutations in protein kinase Cγ promote spinocerebellar ataxia type 14 by impairing kinase autoinhibition
CA Pilo, TR Baffi, AP Kornev, MT Kunkel, M Malfavon, DH Chen, ...
Science signaling 15 (753), eabk1147, 2022
32022
Protein Kinase Cγ Mutations Drive Spinocerebellar Ataxia Type 14 by Impairing Autoinhibition
CA Pilo, TR Baffi, AP Kornev, MT Kunkel, M Malfavon, DH Chen, ...
bioRxiv, 2021.06. 24.449810, 2021
12021
Mechanistic biomarker for predicting the survival of pancreatic cancer patients
AC Newton, TR Baffi, GB Mills
US Patent App. 17/909,908, 2023
2023
The Molecular Basis of Protein Kinase C Regulatory Mechanisms in Cancer and Neurodegenerative Disease
TR Baffi
University of California, San Diego, 2019
2019
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