| p27 allosterically activates cyclin-dependent kinase 4 and antagonizes palbociclib inhibition KZ Guiley, JW Stevenson, K Lou, KJ Barkovich, V Kumarasamy, ... Science 366 (6471), eaaw2106, 2019 | 184 | 2019 |
| CDK/cyclin dependencies define extreme cancer cell-cycle heterogeneity and collateral vulnerabilities ES Knudsen, V Kumarasamy, R Nambiar, JD Pearson, P Vail, ... Cell reports 38 (9), 2022 | 82 | 2022 |
| Targeting dual signalling pathways in concert with immune checkpoints for the treatment of pancreatic cancer ES Knudsen, V Kumarasamy, S Chung, A Ruiz, P Vail, S Tzetzo, J Wu, ... Gut 70 (1), 127-138, 2021 | 72 | 2021 |
| Cell cycle plasticity driven by MTOR signaling: integral resistance to CDK4/6 inhibition in patient-derived models of pancreatic cancer ES Knudsen, V Kumarasamy, A Ruiz, J Sivinski, S Chung, A Grant, P Vail, ... Oncogene 38 (18), 3355-3370, 2019 | 58 | 2019 |
| Functional determinants of cell cycle plasticity and sensitivity to CDK4/6 inhibition V Kumarasamy, P Vail, R Nambiar, AK Witkiewicz, ES Knudsen Cancer research 81 (5), 1347-1360, 2021 | 54 | 2021 |
| Chemotherapy and CDK4/6 inhibitors: unexpected bedfellows PJ Roberts, V Kumarasamy, AK Witkiewicz, ES Knudsen Molecular cancer therapeutics 19 (8), 1575-1588, 2020 | 50 | 2020 |
| Involvement of G-quadruplex structures in regulation of human RET gene expression by small molecules in human medullary thyroid carcinoma TT cells YJ Shin, V Kumarasamy, D Camacho, D Sun Oncogene 34 (10), 1292-1299, 2015 | 43 | 2015 |
| Selective repression of RET proto-oncogene in medullary thyroid carcinoma by a natural alkaloid berberine VM Kumarasamy, YJ Shin, J White, D Sun BMC cancer 15, 1-13, 2015 | 36 | 2015 |
| Chemotherapy impacts on the cellular response to CDK4/6 inhibition: distinct mechanisms of interaction and efficacy in models of pancreatic cancer V Kumarasamy, A Ruiz, R Nambiar, AK Witkiewicz, ES Knudsen Oncogene 39 (9), 1831-1845, 2020 | 33 | 2020 |
| Cancer cell cycle dystopia: heterogeneity, plasticity, and therapy AK Witkiewicz, V Kumarasamy, I Sanidas, ES Knudsen Trends in cancer 8 (9), 711-725, 2022 | 24 | 2022 |
| Demonstration of a potent RET transcriptional inhibitor for the treatment of medullary thyroid carcinoma based on an ellipticine derivative VM Kumarasamy, D Sun International Journal of Oncology 51 (1), 145-157, 2017 | 18 | 2017 |
| The BET inhibitor/degrader ARV-825 prolongs the growth arrest response to Fulvestrant+ Palbociclib and suppresses proliferative recovery in ER-positive breast cancer RM Finnegan, AM Elshazly, NH Patel, L Tyutyunyk-Massey, TH Tran, ... Frontiers in Oncology 12, 966441, 2023 | 16 | 2023 |
| Salinomycin and its derivatives as potent RET transcriptional inhibitors for the treatment of medullary thyroid carcinoma T Alqahtani, VM Kumarasamy, A Huczyński, D Sun International Journal of Oncology 56 (1), 348-358, 2020 | 14 | 2020 |
| RB loss determines selective resistance and novel vulnerabilities in ER-positive breast cancer models V Kumarasamy, R Nambiar, J Wang, H Rosenheck, AK Witkiewicz, ... Oncogene 41 (27), 3524-3538, 2022 | 11 | 2022 |
| The extracellular niche and tumor microenvironment enhance KRAS inhibitor efficacy in pancreatic cancer V Kumarasamy, J Wang, C Frangou, Y Wan, A Dynka, H Rosenheck, ... Cancer research 84 (7), 1115-1132, 2024 | 10 | 2024 |
| PROTAC-mediated CDK degradation differentially impacts cancer cell cycles due to heterogeneity in kinase dependencies V Kumarasamy, Z Gao, B Zhao, B Jiang, SM Rubin, K Burgess, ... British journal of cancer 129 (8), 1238-1250, 2023 | 5 | 2023 |
| Adefovir Dipivoxil as a Therapeutic Candidate for Medullary Thyroid Carcinoma: Targeting RET and STAT3 Proto-Oncogenes T Alqahtani, V Kumarasamy, SS Alghamdi, RS Suliman, K Bin Saleh, ... Cancers 15 (7), 2163, 2023 | 5 | 2023 |
| Pharmacologically targeting KRASG12D in PDAC models: tumor cell intrinsic and extrinsic impact V Kumarasamy, C Frangou, J Wang, Y Wan, A Dynka, H Rosenheck, ... bioRxiv, 2023.03. 18.533261, 2023 | 2 | 2023 |
| Synthesis of Constrained Heterocycles Employing Two Post‐Ugi Cyclization Methods for Rapid Library Generation with In Cellulo Activity N McConnell, Z Xu, V Kumarasamy, D Sun, B Frett, H Li ChemistrySelect 2 (35), 11821-11825, 2017 | 2 | 2017 |
| A natural alkaloid, berberine, as a novel transcriptional repressor of RET proto-oncogene in medullary thyroid carcinoma D Sun, V Kumarasamy Cancer Research 75 (15_Supplement), 5546-5546, 2015 | 2 | 2015 |
