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Desmond Wai Loon Chin
Desmond Wai Loon Chin
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Disruption of Runx1 and Runx3 leads to bone marrow failure and leukemia predisposition due to transcriptional and DNA repair defects
CQ Wang, V Krishnan, LS Tay, DWL Chin, CP Koh, JY Chooi, GSS Nah, ...
Cell reports 8 (3), 767-782, 2014
1042014
PRMT5 modulates splicing for genome integrity and preserves proteostasis of hematopoietic stem cells
DQ Tan, Y Li, C Yang, J Li, SH Tan, DWL Chin, A Nakamura-Ishizu, ...
Cell reports 26 (9), 2316-2328. e6, 2019
902019
Rap1 regulates hematopoietic stem cell survival and affects oncogenesis and response to chemotherapy
E Khattar, KZY Maung, CL Chew, A Ghosh, MMH Mok, P Lee, J Zhang, ...
Nature Communications 10 (1), 5349, 2019
412019
High mitochondrial mass is associated with reconstitution capacity and quiescence of hematopoietic stem cells
Y Takihara, A Nakamura-Ishizu, DQ Tan, M Fukuda, T Matsumura, ...
Blood Advances 3 (15), 2323-2327, 2019
362019
Mouse models for core binding factor leukemia
DWL Chin, N Watanabe-Okochi, CQ Wang, V Tergaonkar, M Osato
Leukemia 29 (10), 1970-1980, 2015
282015
Cbfb deficiency results in differentiation blocks and stem/progenitor cell expansion in hematopoiesis
CQ Wang, DWL Chin, JY Chooi, WJ Chng, I Taniuchi, V Tergaonkar, ...
Leukemia 29 (3), 753-757, 2015
242015
Adhesion, proliferation, and gene expression profile of human umbilical vein endothelial cells cultured on bilayered polyelectrolyte coatings composed of glycosaminoglycans
BC Heng, PP Bezerra, QR Meng, DWL Chin, LB Koh, H Li, H Zhang, ...
Biointerphases 5 (3), FA53-FA62, 2010
222010
RUNX1 haploinsufficiency results in granulocyte colony-stimulating factor hypersensitivity
DWL Chin, M Sakurai, GSS Nah, L Du, B Jacob, T Yokomizo, ...
Blood cancer journal 6 (1), e379-e379, 2016
212016
Canonical Notch signaling is dispensable for adult steady-state and stress myelo-erythropoiesis
S Duarte, PS Woll, N Buza-Vidas, DWL Chin, H Boukarabila, TC Luis, ...
Blood, The Journal of the American Society of Hematology 131 (15), 1712-1719, 2018
192018
Aged healthy mice acquire clonal hematopoiesis mutations
DWL Chin, T Yoshizato, S Virding Culleton, F Grasso, M Barbachowska, ...
Blood, The Journal of the American Society of Hematology 139 (4), 629-634, 2022
172022
Thrombopoietin maintains cell numbers of hematopoietic stem and progenitor cells with megakaryopoietic potential
A O’Neill, D Chin, D Tan, A Nakamura-Ishizu, T Suda
haematologica 106 (7), 1883, 2021
132021
Prolonged maintenance of hematopoietic stem cells that escape from thrombopoietin deprivation
A Nakamura-Ishizu, DWL Chin, T Matsumura, DQ Tan, ...
Blood, The Journal of the American Society of Hematology 137 (19), 2609-2620, 2021
62021
AT cell receptor targeting a recurrent driver mutation in FLT3 mediates elimination of primary human acute myeloid leukemia in vivo
E Giannakopoulou, M Lehander, S Virding Culleton, W Yang, Y Li, ...
Nature Cancer 4 (10), 1474-1490, 2023
32023
Panhematopoietic RNA barcoding enables kinetic measurements of nucleate and anucleate lineages and the activation of myeloid clones following acute platelet depletion
EE Wojtowicz, JJ Mistry, V Uzun, C Hellmich, A Scoones, DW Chin, ...
Genome Biology 24 (1), 152, 2023
12023
Phospholipid metabolic adaptation promotes survival of IDH2 mutant acute myeloid leukemia cells
T Morishima, K Takahashi, DWL Chin, Y Wang, K Tokunaga, Y Arima, ...
Cancer science 115 (1), 197-210, 2024
2024
Oncometabolite-Independent Anti-Apoptotic Feature Via Phospholipid Metabolic Adaptation in IDH2 Mutant AML Cells
T Morishima, K Takahashi, DWL Chin, K Tokunaga, Y Arima, M Matsuoka, ...
Blood 140 (Supplement 1), 3012-3013, 2022
2022
Parallel clonal and molecular profiling of hematopoietic stem cells using RNA barcoding
EE Wojtowicz, J Mistry, V Uzun, A Scoones, DW Chin, L Kettyle, F Grasso, ...
bioRxiv, 2022.05. 16.491933, 2022
2022
CHARACTERIZATION OF THPO-INDEPENDENT HEMATOPOIETIC STEM CELLS WHICH ARE INDUCED TO QUIESCENCE
A Nakamura-Ishizu, D Chin, T Matsumura, T Suda
Experimental Hematology 76, S80, 2019
2019
Genetic Ablation or Pharmacological Inhibition of PRMT5 Affects Maintenance of Genomic Integrity in Hematopoietic Stem Cells
DQ Tan, DWL Chin, Y Li, A Nakamura-Ishizu, H Yang, T Suda
Blood 130, 711, 2017
2017
PRMT5 is required for the maintenance of genomic integrity in hematopoietic stem cells
D Tan, D Chin, Y Li, KP Ng, A Nakamura-Ishizu, H Yang, T Suda
Experimental Hematology 53, S48, 2017
2017
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