| Lanosterol reverses protein aggregation in cataracts L Zhao, XJ Chen, J Zhu, YB Xi, X Yang, LD Hu, H Ouyang, SH Patel, X Jin, ... Nature 523 (7562), 607-611, 2015 | 469 | 2015 |
| A novel CRYGD mutation (p.Trp43Arg) causing autosomal dominant congenital cataract in a Chinese family B Wang, C Yu, YB Xi, HC Cai, J Wang, S Zhou, S Zhou, Y Wu, YB Yan, ... Human mutation 32 (1), E1939-E1947, 2011 | 60 | 2011 |
| A novel mutation impairing the tertiary structure and stability of γC‐crystallin (CRYGC) leads to cataract formation in humans and zebrafish lens XQ Li, HC Cai, SY Zhou, JH Yang, YB Xi, XB Gao, WJ Zhao, P Li, ... Human mutation 33 (2), 391-401, 2012 | 43 | 2012 |
| The congenital cataract-linked G61C mutation destabilizes γD-crystallin and promotes non-native aggregation W Zhang, HC Cai, FF Li, YB Xi, X Ma, YB Yan PLoS One 6 (5), e20564, 2011 | 32 | 2011 |
| Congenital cataract-causing mutation G129C in γC-Crystallin promotes the accumulation of two distinct unfolding intermediates that form highly toxic aggregates YB Xi, XJ Chen, WJ Zhao, YB Yan Journal of molecular biology 427 (17), 2765-2781, 2015 | 28 | 2015 |
| The congenital cataract-linked A2V mutation impairs tetramer formation and promotes aggregation of βB2-crystallin J Xu, S Wang, WJ Zhao, YB Xi, YB Yan, K Yao PLoS One 7 (12), e51200, 2012 | 27 | 2012 |
| Synthesis, evaluation, and structure–activity relationship study of lanosterol derivatives to reverse mutant-crystallin-induced protein aggregation X Yang, XJ Chen, Z Yang, YB Xi, L Wang, Y Wu, YB Yan, Y Rao Journal of Medicinal Chemistry 61 (19), 8693-8706, 2018 | 23 | 2018 |
| Congenital microcornea-cataract syndrome-causing mutation X253R increases βB1-crystallin hydrophobicity to promote aggregate formation XY Leng, HY Li, J Wang, LB Qi, YB Xi, YB Yan Biochemical Journal 473 (14), 2087-2096, 2016 | 22 | 2016 |
| Cataract-linked mutation R188H promotes βB2-crystallin aggregation and fibrillization during acid denaturation YB Xi, K Zhang, AB Dai, SR Ji, K Yao, YB Yan Biochemical and Biophysical Research Communications 447 (2), 244-249, 2014 | 21 | 2014 |
| Membrane insertion of αA-crystallin is oligomer-size dependent HC Tjondro, YB Xi, XJ Chen, JT Su, YB Yan Biochemical and Biophysical Research Communications 473 (1), 1-7, 2016 | 20 | 2016 |
| Cataract-causing mutation R233H affects the stabilities of βB1-and βA3/βB1-crystallins with different pH-dependence YB Xi, WJ Zhao, XT Zuo, HC Tjondro, J Li, AB Dai, S Wang, YB Yan Biochimica et Biophysica Acta (BBA)-Molecular Basis of Disease 1842 (11 …, 2014 | 18 | 2014 |
| The cataract-causing mutation G75V promotes γs-crystallin aggregation by modifying and destabilizing the native structure S Zhu, XB Xi, TL Duan, Y Zhai, J Li, YB Yan, K Yao International journal of biological macromolecules 117, 807-814, 2018 | 17 | 2018 |
| Nonretinoid chaperones improve rhodopsin homeostasis in a mouse model of retinitis pigmentosa A Vats, Y Xi, B Feng, OD Clinger, AJS Leger, X Liu, A Ghosh, ... JCI insight 7 (10), 2022 | 8 | 2022 |
| A novel F30S mutation in γS-crystallin causes autosomal dominant congenital nuclear cataract by increasing susceptibility to stresses KJ Wang, XY Liao, K Lin, YB Xi, S Wang, XH Wan, YB Yan International Journal of Biological Macromolecules 172, 475-482, 2021 | 5 | 2021 |
| Potent retinal protection by oral administration of a purine metabolite against age-related retinal degeneration and RHO-associated retinitis pigmentosa O Clinger, Y Xi, A Vats, A Wolf-Johnson, L Birder, E Jackson, JA Sahel, ... Investigative Ophthalmology & Visual Science 63 (7), 1777–F0326-1777–F0326, 2022 | 3 | 2022 |
| Nicotine dose-dependent epigenomic-wide DNA methylation changes in the mice with long-term electronic cigarette exposure G Peng, Y Xi, C Bellini, K Pham, ZW Zhuang, Q Yan, M Jia, G Wang, L Lu, ... American Journal of Cancer Research 12 (8), 3679, 2022 | 3 | 2022 |
| Celastrol regulates the oligomeric state and chaperone activity of ΑB-crystallin linked with protein homeostasis in the lens H Wang, Q Tian, Y Zhang, Y Xi, L Hu, K Yao, J Li, X Chen Fundamental Research, 2022 | 1 | 2022 |
| Oral 8-aminoguanine against age-related retinal degeneration Y Chen, A Vats, Y Xi, A Wolf-Johnston, O Clinger, R Arbuckle, C Dermond, ... | | 2024 |
| The 18th amino acid glycine plays an essential role in maintaining the structural stabilities of γS-crystallin linking with congenital cataract S Zhu, Y Xi, J Xu, L Hu, C Luo, K Yao, X Chen International Journal of Biological Macromolecules 251, 126339, 2023 | | 2023 |
| 8-Aminoguanine protects the retina from age-related degeneration. Y Chen, A Vats, Y Xi, A Wolf-johnston, OD Clinger, R Arbuckle, L Birder, ... Investigative Ophthalmology & Visual Science 64 (8), 2598-2598, 2023 | | 2023 |
