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Michael P Hay
Michael P Hay
Associate Professor, University of Auckland
Verified email at auckland.ac.nz - Homepage
Title
Cited by
Cited by
Year
Targeting hypoxia in cancer therapy
WR Wilson, MP Hay
Nature Reviews Cancer 11 (6), 393-410, 2011
26802011
Targeting GLUT1 and the Warburg effect in renal cell carcinoma by chemical synthetic lethality
DA Chan, PD Sutphin, P Nguyen, S Turcotte, EW Lai, A Banh, ...
Science translational medicine 3 (94), 94ra70-94ra70, 2011
4502011
A molecule targeting VHL-deficient renal cell carcinoma that induces autophagy
S Turcotte, DA Chan, PD Sutphin, MP Hay, WA Denny, AJ Giaccia
Cancer cell 14 (1), 90-102, 2008
2662008
Use of three-dimensional tissue cultures to model extravascular transport and predict in vivo activity of hypoxia-targeted anticancer drugs
KO Hicks, FB Pruijn, TW Secomb, MP Hay, R Hsu, JM Brown, WA Denny, ...
Journal of the National Cancer Institute 98 (16), 1118-1128, 2006
1622006
Recent developments in the design of bioreductive drugs.
WA Denny, WR Wilson, MP Hay
The British journal of cancer. Supplement 27, S32, 1996
1351996
Structure− activity relationships of 1, 2, 4-benzotriazine 1, 4-dioxides as hypoxia-selective analogues of tirapazamine
MP Hay, SA Gamage, MS Kovacs, FB Pruijn, RF Anderson, AV Patterson, ...
Journal of medicinal chemistry 46 (1), 169-182, 2003
1282003
Pharmacokinetic/pharmacodynamic modeling identifies SN30000 and SN29751 as tirapazamine analogues with improved tissue penetration and hypoxic cell killing in tumors
KO Hicks, BG Siim, JK Jaiswal, FB Pruijn, AM Fraser, R Patel, A Hogg, ...
Clinical Cancer Research 16 (20), 4946-4957, 2010
1262010
Activation of 3-amino-1, 2, 4-benzotriazine 1, 4-dioxide antitumor agents to oxidizing species following their one-electron reduction
RF Anderson, SS Shinde, MP Hay, SA Gamage, WA Denny
Journal of the American Chemical Society 125 (3), 748-756, 2003
1192003
Hypoxia-selective antitumor agents. 8. Bis (nitroimidazolyl) alkanecarboxamides: a new class of hypoxia-selective cytotoxins and hypoxic cell radiosensitizers
MP Hay, WR Wilson, JW Moselen, BD Palmer, WA Denny
Journal of medicinal chemistry 37 (3), 381-391, 1994
931994
DNA-targeted 1, 2, 4-benzotriazine 1, 4-dioxides: Potent analogues of the hypoxia-selective cytotoxin tirapazamine
MP Hay, FB Pruijn, SA Gamage, HDS Liyanage, MS Kovacs, ...
Journal of medicinal chemistry 47 (2), 475-488, 2004
882004
Synthesis and evaluation of nitroheterocyclic carbamate prodrugs for use with nitroreductase-mediated gene-directed enzyme prodrug therapy
MP Hay, RF Anderson, DM Ferry, WR Wilson, WA Denny
Journal of medicinal chemistry 46 (25), 5533-5545, 2003
882003
Tricyclic [1, 2, 4] triazine 1, 4-dioxides as hypoxia selective cytotoxins
MP Hay, KO Hicks, K Pchalek, HH Lee, A Blaser, FB Pruijn, RF Anderson, ...
Journal of medicinal chemistry 51 (21), 6853-6865, 2008
782008
Selective reaction of glycine residues in hydrogen atom transfer from amino acid derivatives
VA Burgess, CJ Easton, MP Hay
Journal of the American Chemical Society 111 (3), 1047-1052, 1989
761989
A 2-nitroimidazole carbamate prodrug of 5-amino-1-(chloromethyl)-3-[(5, 6, 7-trimethoxyindol-2-yl) carbonyl]-1, 2-dihydro-3H-benz [e] indole (amino-seco-CBI-TMI) for use with …
MP Hay, BM Sykes, WA Denny, WR Wilson
Bioorganic & medicinal chemistry letters 9 (15), 2237-2242, 1999
731999
Substituent effects on the kinetics of reductively-initiated fragmentation of nitrobenzyl carbamates designed as triggers for bioreductive prodrugs
MP Hay, BM Sykes, WA Denny, CJ O’Connor
Journal of the Chemical Society, Perkin Transactions 1, 2759-2770, 1999
721999
4-Pyridylanilinothiazoles that selectively target von Hippel− Lindau deficient renal cell carcinoma cells by inducing autophagic cell death
MP Hay, S Turcotte, JU Flanagan, M Bonnet, DA Chan, PD Sutphin, ...
Journal of medicinal chemistry 53 (2), 787-797, 2010
672010
The 2-nitroimidazole EF5 is a biomarker for oxidoreductases that activate the bioreductive prodrug CEN-209 under hypoxia
J Wang, A Foehrenbacher, J Su, R Patel, MP Hay, KO Hicks, WR Wilson
Clinical Cancer Research 18 (6), 1684-1695, 2012
642012
Design, synthesis and evaluation of imidazolylmethyl carbamate prodrugs of alkylating agents
MP Hay, WR Wilson, WA Denny
Tetrahedron 56 (4), 645-657, 2000
632000
A novel enediyne prodrug for antibody-directed enzyme prodrug therapy (ADEPT) using E. coli B nitroreductase
MP Hay, WR Wilson, WA Denny
Bioorganic & Medicinal Chemistry Letters 5 (23), 2829-2834, 1995
601995
Extravascular transport of drugs in tumor tissue: effect of lipophilicity on diffusion of tirapazamine analogues in multicellular layer cultures
FB Pruijn, JR Sturman, HDS Liyanage, KO Hicks, MP Hay, WR Wilson
Journal of medicinal chemistry 48 (4), 1079-1087, 2005
592005
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