| A rare IL33 loss-of-function mutation reduces blood eosinophil counts and protects from asthma D Smith, H Helgason, P Sulem, US Bjornsdottir, AC Lim, ... PLoS Genetics 13 (3), e1006659, 2017 | 131 | 2017 |
| Mammalian ykt6 is a neuronal SNARE targeted to a specialized compartment by its profilin-like amino terminal domain H Hasegawa, S Zinsser, Y Rhee, EO Vik-Mo, S Davanger, JC Hay Molecular biology of the cell 14 (2), 698-720, 2003 | 97 | 2003 |
| A novel antibody engineering strategy for making monovalent bispecific heterodimeric IgG antibodies by electrostatic steering mechanism Z Liu, EC Leng, K Gunasekaran, M Pentony, M Shen, M Howard, J Stoops, ... Journal of Biological Chemistry 290 (12), 7535-7562, 2015 | 93 | 2015 |
| In Vivo Crystallization of Human IgG in the Endoplasmic Reticulum of Engineered Chinese Hamster Ovary (CHO) Cells H Hasegawa, J Wendling, F He, E Trilisky, R Stevenson, H Franey, ... Journal of Biological Chemistry 286 (22), 19917-19931, 2011 | 75 | 2011 |
| Native IL-32 is released from intestinal epithelial cells via a non-classical secretory pathway as a membrane-associated protein H Hasegawa, HJ Thomas, K Schooley, TL Born Cytokine 53 (1), 74-83, 2011 | 72 | 2011 |
| Intramolecular protein-protein and protein-lipid interactions control the conformation and subcellular targeting of neuronal Ykt6 H Hasegawa, Z Yang, L Oltedal, S Davanger, JC Hay Journal of Cell Science 117 (19), 4495-4508, 2004 | 67 | 2004 |
| Russell body inducing threshold depends on the variable domain sequences of individual human IgG clones and the cellular protein homeostasis J Stoops, S Byrd, H Hasegawa Biochimica et Biophysica Acta (BBA)-Molecular Cell Research 1823 (10), 1643-1657, 2012 | 45 | 2012 |
| Fusion partners can increase the expression of recombinant interleukins via transient transfection in 2936E cells J Carter, J Zhang, TL Dang, H Hasegawa, JD Cheng, I Gianan, JW O'Neill, ... Protein Science 19 (2), 357-362, 2010 | 36 | 2010 |
| Aggregates, crystals, gels, and amyloids: intracellular and extracellular phenotypes at the crossroads of immunoglobulin physicochemical property and cell physiology H Hasegawa International journal of cell biology 2013, 2013 | 31 | 2013 |
| Development of a high-throughput fluoroimmunoassay for Syk kinase and Syk kinase inhibitors N Yamamoto, H Hasegawa, H Seki, K Ziegelbauer, T Yasuda Analytical biochemistry 315 (2), 256-261, 2003 | 19 | 2003 |
| Russell body phenotype is preferentially induced by IgG mAb clones with high intrinsic condensation propensity: relations between the biosynthetic events in the ER and solution … H Hasegawa, CE Woods, F Kinderman, F He, AC Lim mAbs 6 (6), 1518-1532, 2014 | 18 | 2014 |
| Modulation of in vivo IgG crystallization in the secretory pathway by heavy chain isotype class switching and N-linked glycosylation H Hasegawa, C Forte, I Barber, S Turnbaugh, J Stoops, M Shen, AC Lim Biochimica et Biophysica Acta (BBA)-Molecular Cell Research 1843 (7), 1325–1338, 2014 | 16 | 2014 |
| R‐SNARE ykt6 resides in membrane‐associated protease‐resistant protein particles and modulates cell cycle progression when over‐expressed N Thayanidhi, Y Liang, H Hasegawa, DC Nycz, V Oorschot, ... Biology of the Cell 104 (7), 397-417, 2012 | 15 | 2012 |
| Single amino acid substitution in LC-CDR1 induces Russell body phenotype that attenuates cellular protein synthesis through eIF2α phosphorylation and thereby downregulates IgG … H Hasegawa, A Hsu, CE Tinberg, KE Siegler, AA Nazarian, MM Tsai mAbs 9 (5), 854-873, 2017 | 13 | 2017 |
| Simultaneous induction of distinct protein phase separation events in multiple subcellular compartments of a single cell H Hasegawa Experimental Cell Research 379 (1), 92-109, 2019 | 10 | 2019 |
| Topogenesis and cell surface trafficking of GPR34 are facilitated by positive-inside rule that effects through a tri-basic motif in the first intracellular loop H Hasegawa, N Patel, E Ettehadieh, P Li, AC Lim Biochimica et Biophysica Acta (BBA)-Molecular Cell Research 1863 (7), 1534-1551, 2016 | 7 | 2016 |
| CYCLIC CARBOXYLIC ACIDS AS INTEGRIN ANTAGONISTS T Lehmann, R Fischer, M Albers, T Roelle, G Mueller, G Hessler, M Tajimi, ... EP Patent 1,276,714, 2003 | 6 | 2003 |
| Membrane cholesterol modulates STEAP2 conformation during dynamic intracellular trafficking processes leading to broad subcellular distribution H Hasegawa, C Li, BM Alba, DM Penny, Z Xia, MR Dayao, P Li, J Zhang, ... Experimental Cell Research 370 (2), 208-226, 2018 | 5 | 2018 |
| Overexpression of cryoglobulin‐like single‐chain antibody induces morular cell phenotype via liquid–liquid phase separation in the secretory pathway organelles H Hasegawa, N Patel, AC Lim FEBS Journal 282 (15), 2777-2795, 2015 | 5 | 2015 |
| Diverse functions of reactive cysteines facilitate unique biosynthetic processes of aggregate-prone interleukin-31 M Shen, S Siu, S Byrd, KH Edelmann, N Patel, RR Ketchem, C Mehlin, ... Experimental Cell Research 317 (7), 976-993, 2011 | 5 | 2011 |
