关注
Angel Guzman-Perez
Angel Guzman-Perez
Head of Drug Discovery, Scorpion Therapeutics
在 scorpiontx.com 的电子邮件经过验证
标题
引用次数
引用次数
年份
The catalytic enantioselective construction of molecules with quaternary carbon stereocenters
EJ Corey, A GuzmanPerez
Angewandte Chemie International Edition 37 (4), 388-401, 1998
13761998
Correction to Analyzing Learned Molecular Representations for Property Prediction.
K Yang, K Swanson, W Jin, C Coley, P Eiden, H Gao, A Guzman-Perez, ...
Journal of chemical information and modeling 59 (12), 5304, 2019
1221*2019
Analyzing learned molecular representations for property prediction
K Yang, K Swanson, W Jin, C Coley, P Eiden, H Gao, A Guzman-Perez, ...
Journal of chemical information and modeling 59 (8), 3370-3388, 2019
12212019
Der katalytische enantioselektive Aufbau von Molekülen mit quartären KohlenstoffStereozentren
EJ Corey, A GuzmanPerez
Angewandte Chemie 110 (4), 402-415, 1998
2991998
The application of a mechanistic model leads to the extension of the Sharpless asymmetric dihydroxylation to allylic 4-methoxybenzoates and conformationally related amine and …
EJ Corey, A Guzman-Perez, MC Noe
Journal of the American Chemical Society 117 (44), 10805-10816, 1995
1891995
Proline-rich tyrosine kinase 2 regulates osteoprogenitor cells and bone formation, and offers an anabolic treatment approach for osteoporosis
L Buckbinder, DT Crawford, H Qi, HZ Ke, LM Olson, KR Long, ...
Proceedings of the National Academy of Sciences 104 (25), 10619-10624, 2007
1772007
Demonstration of the synthetic power of oxazaborolidine-catalyzed enantioselective Diels-Alder reactions by very efficient routes to cassiol and gibberellic acid
EJ Corey, A Guzman-Perez, TP Loh
Journal of the American Chemical Society 116 (8), 3611-3612, 1994
1361994
Discovery of (S)-6-(3-Cyclopentyl-2-(4-(trifluoromethyl)-1H-imidazol-1-yl)propanamido)nicotinic Acid as a Hepatoselective Glucokinase Activator Clinical …
JA Pfefferkorn, A Guzman-Perez, J Litchfield, R Aiello, JL Treadway, ...
Journal of medicinal chemistry 55 (3), 1318-1333, 2012
1322012
Short enantioselective synthesis of (-)-ovalicin, a potent inhibitor of angiogenesis, using substrate-enhanced catalytic asymmetric dihydroxylation
EJ Corey, A Guzman-Perez, MC Noe
Journal of the American Chemical Society 116 (26), 12109-12110, 1994
1261994
A novel sodium-hydrogen exchanger isoform-1 inhibitor, zoniporide, reduces ischemic myocardial injury in vitro and in vivo
DR Knight, AH Smith, DM Flynn, JT MacAndrew, SS Ellery, JX Kong, ...
Journal of Pharmacology and Experimental Therapeutics 297 (1), 254-259, 2001
1052001
Discovery of PF-04620110, a potent, selective, and orally bioavailable inhibitor of DGAT-1
RL Dow, JC Li, MP Pence, EM Gibbs, JL LaPerle, J Litchfield, ...
ACS medicinal chemistry letters 2 (5), 407-412, 2011
972011
Discovery of zoniporide: A potent and selective sodium–hydrogen exchanger type 1 (NHE-1) inhibitor with high aqueous solubility
A Guzman-Perez, RT Wester, MC Allen, JA Brown, AR Buchholz, ...
Bioorganic & medicinal chemistry letters 11 (6), 803-807, 2001
962001
Discovery of novel, induced-pocket binding oxazolidinones as potent, selective, and orally bioavailable tankyrase inhibitors
H Bregman, N Chakka, A Guzman-Perez, H Gunaydin, Y Gu, X Huang, ...
Journal of medicinal chemistry 56 (11), 4320-4342, 2013
872013
Sulfoximine-substituted trifluoromethylpyrimidine analogs as inhibitors of proline-rich tyrosine kinase 2 (PYK2) show reduced hERG activity
DP Walker, MP Zawistoski, MA McGlynn, JC Li, DW Kung, PC Bonnette, ...
Bioorganic & medicinal chemistry letters 19 (12), 3253-3258, 2009
852009
Pyridones as glucokinase activators: identification of a unique metabolic liability of the 4-sulfonyl-2-pyridone heterocycle
JA Pfefferkorn, J Lou, ML Minich, KJ Filipski, M He, R Zhou, S Ahmed, ...
Bioorganic & medicinal chemistry letters 19 (12), 3247-3252, 2009
792009
Kinetic resolution by enantioselective dihydroxylation of secondary allylic 4-methoxybenzoate esters using a mechanistically designed cinchona alkaloid catalyst
EJ Corey, MC Noe, A Guzman-Perez
Journal of the American Chemical Society 117 (44), 10817-10824, 1995
781995
An Enantioselective Synthetic Route to Atractyligenin Using the Oxazaborolidine-Catalyzed Reduction of β-Silyl-or β-Stannyl-Substituted α, β-Enones as a Key Step
EJ Corey, A Guzman-Perez, SE Lazerwith
Journal of the American Chemical Society 119 (49), 11769-11776, 1997
771997
Designing glucokinase activators with reduced hypoglycemia risk: discovery of N, N-dimethyl-5-(2-methyl-6-((5-methylpyrazin-2-yl)-carbamoyl) benzofuran-4-yloxy) pyrimidine-2 …
JA Pfefferkorn, A Guzman-Perez, PJ Oates, J Litchfield, G Aspnes, ...
MedChemComm 2 (9), 828-839, 2011
762011
Functionalization of Aromatic Amino Acids via Direct C− H Activation: Generation of Versatile Building Blocks for Accessing Novel Peptide Space
FM Meyer, S Liras, A Guzman-Perez, C Perreault, J Bian, K James
Organic Letters 12 (17), 3870-3873, 2010
702010
Sulfonamides as Selective NaV1.7 Inhibitors: Optimizing Potency, Pharmacokinetics, and Metabolic Properties to Obtain Atropisomeric Quinolinone (AM-0466) that …
RF Graceffa, AA Boezio, J Able, S Altmann, LM Berry, C Boezio, JR Butler, ...
Journal of medicinal chemistry 60 (14), 5990-6017, 2017
642017
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