Matthew Hirschey
Matthew Hirschey
Associate Professor, Duke University
Verified email at - Homepage
Cited by
Cited by
SIRT3 regulates mitochondrial fatty-acid oxidation by reversible enzyme deacetylation
MD Hirschey, T Shimazu, E Goetzman, E Jing, B Schwer, DB Lombard, ...
Nature 464 (7285), 121-125, 2010
Mammalian Sir2 homolog SIRT3 regulates global mitochondrial lysine acetylation
DB Lombard, FW Alt, HL Cheng, J Bunkenborg, RS Streeper, ...
Molecular and cellular biology 27 (24), 8807-8814, 2007
Calorie restriction reduces oxidative stress by SIRT3-mediated SOD2 activation
X Qiu, K Brown, MD Hirschey, E Verdin, D Chen
Cell metabolism 12 (6), 662-667, 2010
Suppression of oxidative stress by β-hydroxybutyrate, an endogenous histone deacetylase inhibitor
T Shimazu, MD Hirschey, J Newman, W He, K Shirakawa, N Le Moan, ...
Science 339 (6116), 211-214, 2013
SIRT3 deficiency and mitochondrial protein hyperacetylation accelerate the development of the metabolic syndrome
MD Hirschey, T Shimazu, E Jing, CA Grueter, AM Collins, B Aouizerat, ...
Molecular cell 44 (2), 177-190, 2011
Sirtuin regulation of mitochondria: energy production, apoptosis, and signaling
E Verdin, MD Hirschey, LWS Finley, MC Haigis
Trends in biochemical sciences 35 (12), 669-675, 2010
Lysine glutarylation is a protein posttranslational modification regulated by SIRT5
M Tan, C Peng, KA Anderson, P Chhoy, Z Xie, L Dai, J Park, Y Chen, ...
Cell metabolism 19 (4), 605-617, 2014
Sirtuin-3 (Sirt3) regulates skeletal muscle metabolism and insulin signaling via altered mitochondrial oxidation and reactive oxygen species production
E Jing, B Emanuelli, MD Hirschey, J Boucher, KY Lee, D Lombard, ...
Proceedings of the national academy of sciences 108 (35), 14608-14613, 2011
SIRT3 deacetylates mitochondrial 3-hydroxy-3-methylglutaryl CoA synthase 2 and regulates ketone body production
T Shimazu, MD Hirschey, L Hua, KE Dittenhafer-Reed, B Schwer, ...
Cell metabolism 12 (6), 654-661, 2010
Metabolic regulation by lysine malonylation, succinylation, and glutarylation
MD Hirschey, Y Zhao
Molecular & Cellular Proteomics 14 (9), 2308-2315, 2015
Nonenzymatic protein acylation as a carbon stress regulated by sirtuin deacylases
GR Wagner, MD Hirschey
Molecular cell 54 (1), 5-16, 2014
Mitochondrial sirtuins
JY Huang, MD Hirschey, T Shimazu, L Ho, E Verdin
Biochimica et Biophysica Acta (BBA)-Proteins and Proteomics 1804 (8), 1645-1651, 2010
Designing a broad-spectrum integrative approach for cancer prevention and treatment
KI Block, C Gyllenhaal, L Lowe, A Amedei, ARMR Amin, A Amin, ...
Seminars in cancer biology 35, S276-S304, 2015
Dysregulated metabolism contributes to oncogenesis
MD Hirschey, RJ DeBerardinis, AME Diehl, JE Drew, C Frezza, MF Green, ...
Seminars in cancer biology 35, S129-S150, 2015
The sirtuins, oxidative stress and aging: an emerging link
PI Merksamer, Y Liu, W He, MD Hirschey, D Chen, E Verdin
Aging (Albany NY) 5 (3), 144, 2013
Mitochondrial protein acetylation regulates metabolism
I Scott, KA Anderson, MD Hirschey
Essays in biochemistry 52, 23-35, 2012
Mitochondria, energetics, epigenetics, and cellular responses to stress
DT Shaughnessy, K McAllister, L Worth, AC Haugen, JN Meyer, ...
Environmental health perspectives 122 (12), 1271-1278, 2014
Lipids reprogram metabolism to become a major carbon source for histone acetylation
E McDonnell, SB Crown, DB Fox, B Kitir, OR Ilkayeva, CA Olsen, ...
Cell reports 17 (6), 1463-1472, 2016
SIRT3 regulates mitochondrial protein acetylation and intermediary metabolism
MD Hirschey, T Shimazu, JY Huang, B Schwer, E Verdin
Cold Spring Harbor symposia on quantitative biology 76, 267-277, 2011
Hepatic insulin signaling is required for obesity-dependent expression of SREBP-1c mRNA but not for feeding-dependent expression
JT Haas, J Miao, D Chanda, Y Wang, E Zhao, ME Haas, M Hirschey, ...
Cell metabolism 15 (6), 873-884, 2012
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