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Thomas Bobinski
Thomas Bobinski
Medicinal Chemist
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Year
Fragment-Based Discovery of MRTX1719, a Synthetic Lethal Inhibitor of the PRMT5•MTA Complex for the Treatment of MTAP-Deleted Cancers
CR Smith, R Aranda, TP Bobinski, DM Briere, AC Burns, JG Christensen, ...
Journal of Medicinal Chemistry 65 (3), 1749-1766, 2022
652022
Highly efficient, convergent, and enantioselective synthesis of phthioceranic acid
S Xu, A Oda, T Bobinski, H Li, Y Matsueda, E Negishi
Angewandte Chemie International Edition 54 (32), 9319-9322, 2015
372015
KRas G12C inhibitors
MA Marx, TP Bobinski, AC Burns, J Gaudino, J Haas, JM Ketcham, ...
US Patent 10,647,715, 2020
102020
EZH2 inhibitors
MA Marx, MR Lee, RA Galemmo, TP Bobinski
US Patent 10,266,542, 2019
62019
Citric acid mediated catalytic osmylation/oxidative cleavage of electron deficient olefins: A vinyl sulfone study
TP Bobinski, PL Fuchs
Tetrahedron letters 56 (28), 4151-4154, 2015
62015
Kras g12c inhibitors
MA Marx, TP Bobinski, AC Burns, J Gaudino, J Haas, JM Ketcham, ...
US Patent App. 16/868,258, 2020
52020
PRC2 inhibitors
MAZ Marx, MR Lee, TP Bobinski, AC Burns, N Arora, JG Christensen, ...
WO2019152419A1, 2019
42019
Mechanism-specified 5-exo termini differentiation of a C32-desmethyl C28–C34 aplyronine A analog segment
TP Bobinski, PL Fuchs
Tetrahedron letters 56 (28), 4155-4158, 2015
42015
Substituted imidazo [1, 2-c] pyrimidines as PRC2 inhibitors
MA Marx, MR Lee, TP Bobinski, AC Burns, N Arora, JG Christensen, ...
US Patent 11,485,738, 2022
22022
Mta-cooperative prmt5 inhibitors
TP BOBINSKI, CR Smith, MA Marx, JM KETCHAM, AC BURNS, ...
12022
Substituted imidazo [1, 2-c] pyrimidines as PRC2 inhibitors
MA Marx, MR Lee, TP Bobinski, AC Burns, N Arora, JG Christensen, ...
US Patent 11,220,509, 2022
12022
Substituted imidazo [1, 2-c] pyrimidines as PRC2 inhibitors
MA Marx, MR Lee, TP Bobinski, AC Burns, N Arora, JG Christensen, ...
US Patent 11,091,495, 2021
12021
MTA-cooperative PRMT5 inhibitors
TP BOBINSKI, CR Smith, MA Marx, JM KETCHAM, AC BURNS, ...
12021
Triphenylphosphine Dibromide
JR Dormoy, B Castro, TP Bobinski
Encyclopedia of Reagents for Organic Synthesis, 1-13, 2001
12001
Abstract ND04: Discovery of ORIC-944, a novel inhibitor of PRC2 with best-in-class properties for the treatment of prostate cancer
MA Marx, AC Burns, N Arora, TP Bobinski, DM Briere, A Calinisan, ...
Cancer Research 84 (7_Supplement), ND04-ND04, 2024
2024
Substituted isoquinolines as rock kinase inhibitors
MR Lee, AJ Varano, TP Bobinski
US Patent 11,912,719, 2024
2024
SUBSTITUTED IMIDAZO [1, 2-c] PYRIMIDINES AS PRC2 INHIBITORS
MA Marx, MR Lee, TP Bobinski, AC Burns, N Arora, JG Christensen, ...
US Patent App. 17/822,667, 2023
2023
MTA-Cooperative PRMT5 Inhibitors
TP Bobinski, CR Smith, MA Marx, JM Ketcham, AC Burns, JD Lawson, ...
US Patent App. 17/942,367, 2023
2023
Inhibidores prmt5 cooperativos de mta
TP Bobinski, CR Smith, MA Marx, JM Ketcham, AC Burns, JD Lawson, ...
2023
MTA-cooperative PRMT5 inhibitors
TP Bobinski, CR Smith, MA Marx, JM Ketcham, AC Burns, JD Lawson, ...
US Patent 11,492,351, 2022
2022
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