| The tyrosine kinase negative regulator c-Cbl as a RING-type, E2-dependent ubiquitin-protein ligase CAP Joazeiro, SS Wing, H Huang, JD Leverson, T Hunter, YC Liu Science 286 (5438), 309-312, 1999 | 1304 | 1999 |
| The E3 ubiquitin ligase itch couples JNK activation to TNFα-induced cell death by inducing c-FLIPL turnover L Chang, H Kamata, G Solinas, JL Luo, S Maeda, K Venuprasad, YC Liu, ... Cell 124 (3), 601-613, 2006 | 863 | 2006 |
| Calcineurin imposes T cell unresponsiveness through targeted proteolysis of signaling proteins V Heissmeyer, F Macián, SH Im, R Varma, S Feske, K Venuprasad, H Gu, ... Nature immunology 5 (3), 255-265, 2004 | 612 | 2004 |
| Jun turnover is controlled through JNK-dependent phosphorylation of the E3 ligase Itch M Gao, T Labuda, Y Xia, E Gallagher, D Fang, YC Liu, M Karin Science 306 (5694), 271-275, 2004 | 487 | 2004 |
| Recognition and ubiquitination of Notch by Itch, a hect-type E3 ubiquitin ligase L Qiu, C Joazeiro, N Fang, HY Wang, C Elly, Y Altman, D Fang, T Hunter, ... Journal of Biological Chemistry 275 (46), 35734-35737, 2000 | 435 | 2000 |
| Dysregulation of T lymphocyte function in itchy mice: a role for Itch in TH2 differentiation D Fang, C Elly, B Gao, N Fang, Y Altman, C Joazeiro, T Hunter, ... Nature immunology 3 (3), 281-287, 2002 | 417 | 2002 |
| Essential role of the E3 ubiquitin ligase Cbl-b in T cell anergy induction MS Jeon, A Atfield, K Venuprasad, C Krawczyk, R Sarao, C Elly, C Yang, ... Immunity 21 (2), 167-177, 2004 | 377 | 2004 |
| Isolation of high-affinity peptide antagonists of 14-3-3 proteins by phage display B Wang, H Yang, YC Liu, T Jelinek, L Zhang, E Ruoslahti, H Fu Biochemistry 38 (38), 12499-12504, 1999 | 369 | 1999 |
| The ubiquitin–protein ligase Itch regulates p73 stability M Rossi, V De Laurenzi, E Munarriz, DR Green, YC Liu, KH Vousden, ... The EMBO journal 24 (4), 836-848, 2005 | 367 | 2005 |
| Ubiquitin ligases and the immune response YC Liu Annu. Rev. Immunol. 22, 81-127, 2004 | 353 | 2004 |
| Proteolysis-independent regulation of PI3K by Cbl-b–mediated ubiquitination in T cells D Fang, YC Liu Nature immunology 2 (9), 870-875, 2001 | 338 | 2001 |
| Activation of the E3 ubiquitin ligase Itch through a phosphorylation-induced conformational change E Gallagher, M Gao, YC Liu, M Karin Proceedings of the National Academy of Sciences 103 (6), 1717-1722, 2006 | 332 | 2006 |
| Immunity by ubiquitylation: a reversible process of modification YC Liu, J Penninger, M Karin Nature Reviews Immunology 5 (12), 941-952, 2005 | 316 | 2005 |
| Transcription factors Foxo3a and Foxo1 couple the E3 ligase Cbl-b to the induction of Foxp3 expression in induced regulatory T cells Y Harada, Y Harada, C Elly, G Ying, JH Paik, RA DePinho, YC Liu Journal of experimental medicine 207 (7), 1381-1391, 2010 | 315 | 2010 |
| Genotoxic stress targets human Chk1 for degradation by the ubiquitin-proteasome pathway YW Zhang, DM Otterness, GG Chiang, W Xie, YC Liu, F Mercurio, ... Molecular cell 19 (5), 607-618, 2005 | 313 | 2005 |
| The tight junction-specific protein occludin is a functional target of the E3 ubiquitin-protein ligase itch A Traweger, D Fang, YC Liu, W Stelzhammer, IA Krizbai, F Fresser, ... Journal of Biological Chemistry 277 (12), 10201-10208, 2002 | 242 | 2002 |
| Cbl-b, a RING-type E3 ubiquitin ligase, targets phosphatidylinositol 3-kinase for ubiquitination in T cells D Fang, HY Wang, N Fang, Y Altman, C Elly, YC Liu Journal of Biological Chemistry 276 (7), 4872-4878, 2001 | 241 | 2001 |
| The E3 ubiquitin ligase Itch regulates expression of transcription factor Foxp3 and airway inflammation by enhancing the function of transcription factor TIEG1 K Venuprasad, H Huang, Y Harada, C Elly, M Subramaniam, T Spelsberg, ... Nature immunology 9 (3), 245-253, 2008 | 216 | 2008 |
| E3 ubiquitin ligase VHL regulates hypoxia-inducible factor-1α to maintain regulatory T cell stability and suppressive capacity JH Lee, C Elly, Y Park, YC Liu Immunity 42 (6), 1062-1074, 2015 | 210 | 2015 |
| Cbl promotes ubiquitination of the T cell receptor ζ through an adaptor function of Zap-70 HY Wang, Y Altman, D Fang, C Elly, Y Dai, Y Shao, YC Liu Journal of Biological Chemistry 276 (28), 26004-26011, 2001 | 199 | 2001 |
