Senolytics reduce coronavirus-related mortality in old mice CD Camell, MJ Yousefzadeh, Y Zhu, LGPL Prata, MA Huggins, M Pierson, ... Science 373 (6552), eabe4832, 2021 | 219 | 2021 |
Cellular senescence in aging and age-related diseases: Implications for neurodegenerative diseases EOW Gerdes, Y Zhu, BM Weigand, U Tripathi, TC Burns, T Tchkonia, ... International review of neurobiology 155, 203-234, 2020 | 72 | 2020 |
SARS-CoV-2 causes senescence in human cells and exacerbates the senescence-associated secretory phenotype through TLR-3 U Tripathi, R Nchioua, LGPL Prata, Y Zhu, EOW Gerdes, N Giorgadze, ... Aging (albany NY) 13 (18), 21838, 2021 | 64 | 2021 |
Impact of senescent cell subtypes on tissue dysfunction and repair: importance and research questions U Tripathi, A Misra, T Tchkonia, JL Kirkland Mechanisms of ageing and development 198, 111548, 2021 | 57 | 2021 |
Partial inhibition of mitochondrial complex I ameliorates Alzheimer’s disease pathology and cognition in APP/PS1 female mice A Stojakovic, S Trushin, A Sheu, L Khalili, SY Chang, X Li, T Christensen, ... Communications biology 4 (1), 61, 2021 | 41 | 2021 |
Orally-active, clinically-translatable senolytics restore α-Klotho in mice and humans Y Zhu, LGPL Prata, EOW Gerdes, JME Netto, T Pirtskhalava, N Giorgadze, ... EBioMedicine 77, 2022 | 39 | 2022 |
Differential effect of amyloid beta peptides on mitochondrial axonal trafficking depends on their state of aggregation and binding to the plasma membrane L Zhang, S Trushin, TA Christensen, U Tripathi, C Hong, RE Geroux, ... Neurobiology of disease 114, 1-16, 2018 | 39 | 2018 |
MICU1 confers protection from MCU-dependent manganese toxicity J Wettmarshausen, V Goh, KT Huang, DM Arduino, U Tripathi, A Leimpek, ... Cell Reports 25 (6), 1425-1435. e7, 2018 | 27 | 2018 |
A genome-wide association study in human lymphoblastoid cells supports safety of mitochondrial complex I inhibitor H Gao, U Tripathi, S Trushin, L Okromelidze, NP Pichurin, L Wei, ... Mitochondrion 58, 83-94, 2021 | 6 | 2021 |
Transplanting old organs promotes senescence in young recipients J Iske, MJ Roesel, F Martin, A Schroeter, T Matsunaga, R Maenosono, ... American Journal of Transplantation 24 (3), 391-405, 2024 | 4 | 2024 |
Development of a novel senolytic by precise disruption of FOXO4-p53 complex U Tripathi, S Chaib, EOW Gerdes, KA Hogan, Y Zhu EBioMedicine 74, 2021 | 4 | 2021 |
Partial inhibition of mitochondrial complex I attenuates neurodegeneration and restores energy homeostasis and synaptic function in a symptomatic Alzheimer’s mouse model A Stojakovic, S Trushin, A Sheu, L Khalili, SY Chang, X Li, T Christensen, ... BioRxiv, 2020.07. 01.182428, 2020 | 2 | 2020 |
Synaptic dysfunction and extracellular matrix dysregulation in dopaminergic neurons from sporadic and E326K-GBA1 Parkinson’s disease patients I Rosh, U Tripathi, Y Hussein, WA Rike, J Djamus, B Shklyar, A Manole, ... npj Parkinson's Disease 10 (1), 38, 2024 | 1 | 2024 |
Upregulated ECM genes and increased synaptic activity in Parkinson’s human DA neurons with PINK1/ PRKN mutations U Tripathi, I Rosh, R Ben Ezer, R Nayak, Y Hussein, A Choudhary, ... npj Parkinson's Disease 10 (1), 103, 2024 | | 2024 |
Targeting Cell Senescence and Senolytics: Novel Interventions for Age-Related Endocrine Dysfunction M Suda, KH Paul, U Tripathi, T Minamino, T Tchkonia, JL Kirkland Endocrine Reviews, bnae010, 2024 | | 2024 |
Partial inhibition of mitochondrial complex I ameliorates Alzheimer's disease pathology and cognition in APP/PS1 female mice (vol 4, 61, 2021) A Stojakovic, S Trushin, A Sheu, L Khalili, SY Chang, X Li, T Christensen, ... COMMUNICATIONS BIOLOGY 7 (1), 2024 | | 2024 |
Author Correction: Partial inhibition of mitochondrial complex I ameliorates Alzheimer’s disease pathology and cognition in APP/PS1 female mice A Stojakovic, S Trushin, A Sheu, L Khalili, SY Chang, X Li, T Christensen, ... Communications Biology 7 (1), 234, 2024 | | 2024 |
Predicting Suicide Risk in Bipolar Disorder patients from Lymphoblastoid Cell Lines genetic signatures O Sharma, R Nayak, L Mizrahi, WA Rike, A Choudhary, Y Hussein, I Rosh, ... bioRxiv, 2024.05. 30.596645, 2024 | | 2024 |
Endothelial Cell Specific Senescent Cell Clearance Alleviated Vascular Stiffness And Metabolic Dysfunction In Obese Mice M Suda, R Huang, CM Roos, L Leon, U Tripathi, JD Miller, T Tchikonia, ... CIRCULATION RESEARCH 133, 2023 | | 2023 |
Abstract P2146: Endothelial Cell Specific Senescent Cell Clearance Alleviated Vascular Stiffness And Metabolic Dysfunction In Obese Mice M Suda, R Huang, CM Roos, L Leon, U Tripathi, JD Miller, T Tchikonia, ... Circulation Research 133 (Suppl_1), AP2146-AP2146, 2023 | | 2023 |