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Patrick C. Freitag
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iMATCH: an integrated modular assembly system for therapeutic combination high-capacity adenovirus gene therapy
D Brücher, N Kirchhammer, SN Smith, J Schumacher, N Schumacher, ...
Molecular Therapy-Methods & Clinical Development 20, 572-586, 2021
252021
The SHREAD gene therapy platform for paracrine delivery improves tumor localization and intratumoral effects of a clinical antibody
SN Smith, R Schubert, B Simic, D Brücher, M Schmid, N Kirk, PC Freitag, ...
Proceedings of the National Academy of Sciences 118 (21), e2017925118, 2021
212021
Unravelling receptor and RGD motif dependence of retargeted adenoviral vectors using advanced tumor model systems
M Chernyavska, M Schmid, PC Freitag, V Palacio-Castañeda, A Piruska, ...
Scientific reports 9 (1), 18568, 2019
182019
Programmable DARPin-based receptors for the detection of thrombotic markers
T Strittmatter, Y Wang, A Bertschi, L Scheller, PC Freitag, PG Ray, ...
Nature chemical biology 18 (10), 1125-1134, 2022
102022
Modular adapters utilizing binders of different molecular types expand cell-targeting options for adenovirus gene delivery
PC Freitag, F Brandl, D Brücher, F Weiss, B Dreier, A Plückthun
Bioconjugate Chemistry 33 (9), 1595-1601, 2022
72022
Targeted adenovirus-mediated transduction of human T cells in vitro and in vivo
PC Freitag, M Kaulfuss, L Flühler, J Mietz, F Weiss, D Brücher, J Kolibius, ...
Molecular Therapy-Methods & Clinical Development 29, 120-132, 2023
52023
Targeted shock-and-kill HIV-1 gene therapy approach combining CRISPR activation, suicide gene tBid and retargeted adenovirus delivery
S Klinnert, CD Schenkel, PC Freitag, HF Günthard, A Plückthun, ...
Gene Therapy 31 (3), 74-84, 2024
32024
FAP-retargeted Ad5 enables in vivo gene delivery to stromal cells in the tumor microenvironment
KP Hartmann, M van Gogh, PC Freitag, F Kast, G Nagy-Davidescu, ...
Molecular Therapy 31 (10), 2914-2928, 2023
32023
Transient Thermal-hydraulic Simulation of a Small modular Reactor in RELAP 5
P Freitag
32018
Dendritic cell targeting in lymph nodes with engineered modular adapters improves HAdV5 and HC-HAdV5 tumor vaccination by co-secretion of IL-2v and IL-21
F Weiss, J Kolibius, PC Freitag, F Gantenbein, A Kipar, A Plueckthun
bioRxiv, 2024.04. 27.591433, 2024
2024
Adapter Development for Targeted Adenoviral-Mediated Engineering of Human T Cells in Vitro and In Vivo
PC Freitag
University of Zurich, 2023
2023
Targeting HIV-1 with CRISPR/Cas9 delivered by retargeted adenoviruses effectively suppresses viral replication
S Klinnert, PC Freitag, A Plueckthun, KJ Metzner
bioRxiv, 2023.12. 18.572146, 2023
2023
Engineering adenoviral vectors for a targeted delivery of therapeutic payloads
KP Hartmann, M Van Gogh, G Nagy-Davidescu, PC Freitag, A Plueckthun
HUMAN GENE THERAPY 33 (23-24), A56-A57, 2022
2022
Zellspezifische Produktion von multiplen Therapeutika im Körper
D Brücher, PC Freitag, A Plückthun
BIOspektrum 28 (2), 155-158, 2022
2022
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