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Michael Beer
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QM/MM simulations reveal the determinants of carbapenemase activity in class A β-lactamases
EI Chudyk, M Beer, MAL Limb, CA Jones, J Spencer, MW Van der Kamp, ...
ACS Infectious Diseases 8 (8), 1521-1532, 2022
122022
Tautomer-specific deacylation and Ω-loop flexibility explain the carbapenem-hydrolyzing broad-spectrum activity of the KPC-2 β-lactamase
CL Tooke, P Hinchliffe, M Beer, K Zinovjev, CK Colenso, CJ Schofield, ...
Journal of the American Chemical Society 145 (13), 7166-7180, 2023
92023
Electric Fields Are a Key Determinant of Carbapenemase Activity in Class A β-Lactamases
H Jabeen, M Beer, J Spencer, MW Van der Kamp, HA Bunzel, ...
ACS catalysis 14 (9), 7166-7172, 2024
12024
Restricted Rotational Flexibility of the C5α-Methyl-Substituted Carbapenem NA-1-157 Leads to Potent Inhibition of the GES-5 Carbapenemase
NK Stewart, M Toth, P Quan, M Beer, JD Buynak, CA Smith, ...
ACS infectious diseases 10 (4), 1232-1249, 2024
2024
Dynamical Responses Predict a Distal Site that Modulates Activity in an Antibiotic Resistance Enzyme
M Beer, ASF Oliveira, CL Tooke, P Hinchliffe, ATY Li, B Balega, J Spencer, ...
bioRxiv, 2024.04. 29.591639, 2024
2024
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