Tryptophan-derived butyrylcholinesterase inhibitors as promising leads against Alzheimer's disease A Meden, D Knez, M Jukič, X Brazzolotto, M Gršič, A Pišlar, A Zahirović, ... Chemical communications 55 (26), 3765-3768, 2019 | 77 | 2019 |
1, 3‐Diamine‐Derived Bifunctional Organocatalyst Prepared from Camphor S Ričko, J Svete, B Štefane, A Perdih, A Golobič, A Meden, U Grošelj Advanced Synthesis & Catalysis 358 (23), 3786-3796, 2016 | 50 | 2016 |
Structure-activity relationship study of tryptophan-based butyrylcholinesterase inhibitors A Meden, D Knez, N Malikowska-Racia, X Brazzolotto, F Nachon, J Svete, ... European Journal of Medicinal Chemistry 208, 112766, 2020 | 21 | 2020 |
From tryptophan-based amides to tertiary amines: Optimization of a butyrylcholinesterase inhibitor series A Meden, D Knez, X Brazzolotto, F Nachon, J Dias, J Svete, J Stojan, ... European journal of medicinal chemistry 234, 114248, 2022 | 17 | 2022 |
Organocatalyzed Deracemization of Δ2‐Pyrrolin‐4‐ones S Ričko, A Meden, A Ivančič, A Perdih, B Štefane, J Svete, U Grošelj Advanced Synthesis & Catalysis 359 (13), 2288-2296, 2017 | 15 | 2017 |
Construction of Vicinal Tetrasubstituted Stereogenic Centers via a Mannich‐Type Organocatalyzed Addition of Δ2‐Pyrrolin‐4‐ones to Isatin Imines S Ričko, A Meden, L Ciber, B Štefane, F Požgan, J Svete, U Grošelj Advanced Synthesis & Catalysis 360 (6), 1072-1076, 2018 | 14 | 2018 |
4-Phenethyl-1-propargylpiperidine-derived dual inhibitors of butyrylcholinesterase and monoamine oxidase B T Mazej, D Knez, A Meden, S Gobec, M Sova Molecules 26 (14), 4118, 2021 | 6 | 2021 |
Repurposing of 8‐Hydroxyquinoline‐Based Butyrylcholinesterase and Cathepsin B Ligands as Potent Nonpeptidic Deoxyribonuclease I Inhibitors M Gajic, D Knez, I Sosič, J Mravljak, A Meden, U Košak, L Leitzbach, ... ChemMedChem 17 (5), e202100694, 2022 | 5 | 2022 |
8-Hydroxyquinolylnitrones as multifunctional ligands for the therapy of neurodegenerative diseases D Knez, D Diez-Iriepa, M Chioua, A Gottinger, M Denic, F Chantegreil, ... Acta Pharmaceutica Sinica B 13 (5), 2152-2175, 2023 | 4 | 2023 |
Discovery of a fragment hit compound targeting D-Ala: D-Ala ligase of bacterial peptidoglycan biosynthesis M Proj, M Hrast, G Bajc, R Frlan, A Meden, M Butala, S Gobec Journal of enzyme inhibition and medicinal chemistry 38 (1), 387-397, 2023 | 2 | 2023 |
Pseudo-irreversible butyrylcholinesterase inhibitors: Structure–activity relationships, computational and crystallographic study of the N-dialkyl O-arylcarbamate warhead A Meden, D Knez, X Brazzolotto, F Modeste, A Perdih, A Pišlar, M Zorman, ... European journal of medicinal chemistry 247, 115048, 2023 | 2 | 2023 |
Focused peptide library screening as a route to a superior affinity ligand for antibody purification K Bozovičar, B Jenko Bizjan, A Meden, J Kovač, T Bratkovič Scientific reports 11 (1), 11650, 2021 | 2 | 2021 |
Načrtovanje in sinteza zaviralcev butirilholinesteraze s triptofanskim skeletom A Meden Univerza v Ljubljani, Fakulteta za farmacijo, 2019 | 2 | 2019 |
A set of experimentally validated decoys for the human CC chemokine receptor 7 (CCR7) obtained by virtual screening M Proj, S De Jonghe, T Van Loy, M Jukič, A Meden, L Ciber, Č Podlipnik, ... Frontiers in pharmacology 13, 855653, 2022 | 1 | 2022 |
Probing Alzheimer's pathology: Exploring the next generation of FDDNP analogues for amyloid β detection L Rejc, D Knez, G Molina-Aguirre, A Espargaró, J Kladnik, A Meden, ... Biomedicine & Pharmacotherapy 175, 116616, 2024 | | 2024 |
Disentangling the formation, mechanism, and evolvement of the covalent methanesulfonyl fluoride acetylcholinesterase adduct: Insights into an aged‐like inactive complex … J Stojan, A Pesaresi, A Meden, D Lamba Protein Science 33 (5), e4977, 2024 | | 2024 |
Synthesis and Cholinesterase Inhibitory Activity of Selected Indole-Based Compounds. M Gršič, A Meden, D Knez, M Jukič, J Svete, S Gobec, U Grošelj Acta Chimica Slovenica 70 (4), 2023 | | 2023 |
Strukturno podprto načrtovanje, sinteza in vrednotenje reverzibilnih in ireverzibilnih zaviralcev butirilholin esteraze A Meden Univerza v Ljubljani, Fakulteta za farmacijo, 2023 | | 2023 |
Pseudo-irreversible butyrylcholinesterase inhibitors: structure–activity relationships, and kinetic, computational, and crystallographic study of the N-dialkyl O-arylcarbamate … A Meden, D Knez, X Brazzolotto, F Modeste, A Perdih, A Pišlar, M Zorman, ... | | 2022 |
Pseudo-irreversible butyrylcholinesterase inhibitors: SAR, kinetic, computational, and crystallographic study of the N-dialkyl O-arylcarbamate warhead A Meden, D Knez, X Brazzolotto, F Modeste, A Perdih, A Pišlar, M Zorman, ... | | 2022 |