| Remdesivir is a direct-acting antiviral that inhibits RNA-dependent RNA polymerase from severe acute respiratory syndrome coronavirus 2 with high potency CJ Gordon, EP Tchesnokov, E Woolner, JK Perry, JY Feng, DP Porter, ... Journal of Biological Chemistry 295 (20), 6785-6797, 2020 | 960 | 2020 |
| The antiviral compound remdesivir potently inhibits RNA-dependent RNA polymerase from Middle East respiratory syndrome coronavirus CJ Gordon, EP Tchesnokov, JY Feng, DP Porter, M Götte Journal of Biological Chemistry 295 (15), 4773-4779, 2020 | 958 | 2020 |
| Molnupiravir promotes SARS-CoV-2 mutagenesis via the RNA template CJ Gordon, EP Tchesnokov, RF Schinazi, M Götte Journal of Biological Chemistry 297 (1), 2021 | 275 | 2021 |
| Template-dependent inhibition of coronavirus RNA-dependent RNA polymerase by remdesivir reveals a second mechanism of action EP Tchesnokov, CJ Gordon, E Woolner, D Kocinkova, JK Perry, JY Feng, ... Journal of Biological Chemistry 295 (47), 16156-16165, 2020 | 143 | 2020 |
| Mutations in the SARS-CoV-2 RNA-dependent RNA polymerase confer resistance to remdesivir by distinct mechanisms LJ Stevens, AJ Pruijssers, HW Lee, CJ Gordon, EP Tchesnokov, J Gribble, ... Science translational medicine 14 (656), eabo0718, 2022 | 123 | 2022 |
| Efficient incorporation and template-dependent polymerase inhibition are major determinants for the broad-spectrum antiviral activity of remdesivir CJ Gordon, HW Lee, EP Tchesnokov, JK Perry, JY Feng, JP Bilello, ... Journal of Biological Chemistry 298 (2), 2022 | 30 | 2022 |
| Evolution of naturally arising SARS-CoV-2 defective interfering particles S Girgis, Z Xu, S Oikonomopoulos, AD Fedorova, EP Tchesnokov, ... Communications Biology 5 (1), 1140, 2022 | 17 | 2022 |
| Inhibition of viral RNA-dependent RNA polymerases with clinically relevant nucleotide analogs K Maheden, B Todd, CJ Gordon, EP Tchesnokov, M Götte The Enzymes 49, 315-354, 2021 | 11 | 2021 |
| The nucleoside/nucleotide analogs tenofovir and emtricitabine are inactive against SARS-CoV-2 JY Feng, V Du Pont, D Babusis, CJ Gordon, EP Tchesnokov, JK Perry, ... Molecules 27 (13), 4212, 2022 | 10 | 2022 |
| Distinct genetic determinants and mechanisms of SARS-CoV-2 resistance to remdesivir LJ Stevens, AJ Pruijssers, HW Lee, CJ Gordon, EP Tchesnokov, J Gribble, ... BioRxiv, 2022.01. 25.477724, 2022 | 4 | 2022 |
| NRTIs tenofovir, TAF, TDF, and FTC are inactive against SARS-CoV-2 JY Feng, JP Bilello, D Babusis, CJ Gordon, EP Tchesnokov, JK Perry, ... Communications 11, 5214, 2020 | 3 | 2020 |
| Mechanism and spectrum of inhibition of a 4′-cyano modified nucleotide analog against diverse RNA polymerases of prototypic respiratory RNA viruses CJ Gordon, SM Walker, EP Tchesnokov, D Kocincova, J Pitts, DS Siegel, ... bioRxiv, 2024.04. 22.590607, 2024 | | 2024 |
| Distinct genetic determinants and mechanisms of SARS-CoV-2 resistance to remdesivir (preprint) LJ Stevens, AJ Pruijssers, HW Lee, CJ Gordon, EP Tchesnokov, J Gribble, ... | | 2022 |
