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Joseph J. Muldoon
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The COMET toolkit for composing customizable genetic programs in mammalian cells
PS Donahue, JW Draut, JJ Muldoon, HI Edelstein, N Bagheri, JN Leonard
Nature Communications 11 (1), 1–19, 2020
632020
Macrophages employ quorum licensing to regulate collective activation
JJ Muldoon, Y Chuang, N Bagheri, JN Leonard
Nature Communications 11 (1), 1–14, 2020
512020
The modifier of transcription 1 (Mot1) ATPase and Spt16 histone chaperone co-regulate transcription through preinitiation complex assembly and nucleosome organization
JD True*, JJ Muldoon*, MN Carver, K Poorey, SJ Shetty, S Bekiranov, ...
Journal of Biological Chemistry 291 (29), 15307–15319, 2016
372016
Multiplexing engineered receptors for multiparametric evaluation of environmental ligands
RM Hartfield*, KA Schwarz*, JJ Muldoon*, N Bagheri, JN Leonard
ACS Synthetic Biology 6 (11), 2042–2055, 2017
312017
Peptide-mediated delivery of CRISPR enzymes for the efficient editing of primary human lymphocytes
DV Foss*, JJ Muldoon*, DN Nguyen*, D Carr, SU Sahu, JM Hunsinger, ...
Nature Biomedical Engineering 7, 647–660, 2023
302023
Elucidation and refinement of synthetic receptor mechanisms
HI Edelstein*, PS Donahue*, JJ Muldoon, AK Kang, TB Dolberg, ...
Synthetic Biology 5 (1), ysaa017, 2020
262020
Model-guided design of mammalian genetic programs
JJ Muldoon, V Kandula, M Hong, PS Donahue, JD Boucher, N Bagheri, ...
Science Advances 7 (8), eabe9375, 2021
232021
An evolved AAV variant enables efficient genetic engineering of murine T cells
WA Nyberg*, J Ark*, A To, S Clouden, G Reeder, JJ Muldoon, JY Chung, ...
Cell 186, 446–460.e19, 2023
202023
Nanofountain probe electroporation enables versatile single‐cell intracellular delivery and investigation of postpulse electropore dynamics
SSP Nathamgari, N Pathak, V Lemaitre, P Mukherjee, JJ Muldoon, ...
Small, 2002616, 2020
202020
Network inference performance complexity: a consequence of topological, experimental, and algorithmic determinants
JJ Muldoon*, JS Yu*, MK Fassia, N Bagheri
Bioinformatics 35 (18), 3421–3432, 2019
142019
GAMES: A dynamic model development workflow for rigorous characterization of synthetic genetic systems
KE Dray, JJ Muldoon, NM Mangan, N Bagheri, JN Leonard
ACS Synthetic Biology 11 (2), 1009–1029, 2022
102022
Building with intent: technologies and principles for engineering mammalian cell-based therapies to sense and respond
JJ Muldoon*, PS Donahue*, TB Dolberg*, JN Leonard
Current Opinion in Biomedical Engineering 4, 127–133, 2017
102017
Ablation of Cullin-5 in Primary Human T Cells Improves Tumor Killing and Persistence in BCMA-Targeting CAR-T Cells in a Multiple Myeloma Model
S Bachl, A Talbot, C Ching, N Kale, Z Li, M Diolaiti, AP Chen, J Muldoon, ...
Blood 142, 99, 2023
12023
Tracking cell-cell interactions using intercellular barcode transfer
NQ Tay, T Juan, JJ Muldoon, J Eyquem, MT McManus
Cancer Research 84 (6_Supplement), 6633-6633, 2024
2024
Ultra-high efficiency T cell reprogramming at multiple loci with SEED-Selection
CR Chang, VS Vykunta, DB Goodman, JJ Muldoon, WA Nyberg, C Liu, ...
bioRxiv, 2024.02. 06.576175, 2024
2024
Targeted Integration of a Chimeric Antigen Receptor in Key Selected Loci in Primary Natural Killer Cells
V Allain, A Rothrock, W Nyberg, J Muldoon, A To, JY Chung, C Chang, ...
Blood 142, 4807, 2023
2023
Engineered mamalian genetic circuits and methods of using the same
JN Leonard, JJ Muldoon, PS Donahue
US Patent App. 18/026,734, 2023
2023
Computational Modeling of Synthetic Gene Circuits to Improve Stem Cell Differentiation
M Hong, J Muldoon, J Leonard
2018 AIChE Annual Meeting, 2018
2018
Computational Design of Synthetic Genetic Programs That Exhibit Pulse Dynamics
M Hong, J Muldoon, PS Donahue, JW Draut, J Leonard
2018 AIChE Annual Meeting, 2018
2018
Comet: A Novel Transcription Toolbox for Engineering Cellular Therapies
PS Donahue, JW Draut, JJ Muldoon, JN Leonard
MOLECULAR THERAPY 26 (5), 76–76, 2018
2018
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Articles 1–20