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Charles "Clint" Valentine
Charles "Clint" Valentine
TwinStrand Biosciences
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Year
Mutational spectra of aflatoxin B1 in vivo establish biomarkers of exposure for human hepatocellular carcinoma
S Chawanthayatham, CC Valentine III, BI Fedeles, EJ Fox, LA Loeb, ...
Proceedings of the National Academy of Sciences 114 (15), E3101-E3109, 2017
1242017
Ultra-sensitive TP53 sequencing for cancer detection reveals progressive clonal selection in normal tissue over a century of human lifespan
JJ Salk, K Loubet-Senear, E Maritschnegg, CC Valentine, LN Williams, ...
Cell Reports 28 (1), 132-144. e3, 2019
782019
Direct quantification of in vivo mutagenesis and carcinogenesis using duplex sequencing
CC Valentine III, RR Young, MR Fielden, R Kulkarni, LN Williams, T Li, ...
Proceedings of the National Academy of Sciences 117 (52), 33414-33425, 2020
632020
Ultra-accurate Duplex Sequencing for the assessment of pretreatment ABL1 kinase domain mutations in Ph+ ALL
NJ Short, H Kantarjian, R Kanagal-Shamanna, K Sasaki, F Ravandi, ...
Blood cancer journal 10 (5), 61, 2020
302020
Duplex sequencing identifies genomic features that determine susceptibility to benzo (a) pyrene-induced in vivo mutations
DPM LeBlanc, M Meier, FY Lo, E Schmidt, C Valentine III, A Williams, ...
BMC genomics 23 (1), 542, 2022
232022
Genetic toxicity testing using human in vitro organotypic airway cultures: Assessing DNA damage with the CometChip and mutagenesis by Duplex Sequencing
Y Wang, RA Mittelstaedt, R Wynne, Y Chen, X Cao, L Muskhelishvili, ...
Environmental and Molecular Mutagenesis 62 (5), 306-318, 2021
192021
Quantification of measurable residual disease using duplex sequencing in adults with acute myeloid leukemia
LW Dillon, J Higgins, H Nasif, M Othus, L Beppu, TH Smith, E Schmidt, ...
Haematologica 109 (2), 401, 2024
102024
Duplex sequencing provides detailed characterization of mutation frequencies and spectra in the bone marrow of MutaMouse males exposed to procarbazine hydrochloride
AE Dodge, DPM LeBlanc, G Zhou, A Williams, MJ Meier, P Van, FY Lo, ...
Archives of Toxicology 97 (8), 2245-2259, 2023
102023
Error-corrected duplex sequencing enables direct detection and quantification of mutations in human TK6 cells with strong inter-laboratory consistency
E Cho, CD Swartz, A Williams, MV Rivas, L Recio, KL Witt, EK Schmidt, ...
Mutation Research/Genetic Toxicology and Environmental Mutagenesis 889, 503649, 2023
62023
Adopting duplex sequencing technology for genetic toxicity testing: A proof-of-concept mutagenesis experiment with N-ethyl-N-nitrosourea (ENU)-exposed rats
SL Smith-Roe, CA Hobbs, V Hull, JT Auman, L Recio, MA Streicker, ...
Mutation Research/Genetic Toxicology and Environmental Mutagenesis 891, 503669, 2023
42023
Methods and reagents for characterizing genomic editing, clonal expansion, and associated applications
CC VALENTINE III
US Patent App. 17/259,501, 2021
42021
Methods and reagents for detecting and assessing genotoxicity
CC VALENTINE III
US Patent App. 16/969,531, 2021
32021
Methods and reagents for resolving nucleic acid mixtures and mixed cell populations and associated applications
CC VALENTINE III, P DANAHER, FY Lo
US Patent App. 17/055,473, 2021
32021
Mitochondrial haplotype and mito-nuclear matching drive somatic mutation and selection throughout ageing
IM Serrano, M Hirose, CC Valentine, S Roesner, E Schmidt, G Pratt, ...
Nature Ecology & Evolution, 1-14, 2024
22024
Next Generation Sequencing Workshop at the Royal Society of Medicine (London, May 2022): how genomics is on the path to modernizing genetic toxicology
AM Lynch, TB Zanoni, JJ Salk, I Martincorena, RR Young, J Kucab, ...
Mutagenesis 38 (4), 192-200, 2023
22023
Methods and reagents for efficient genotyping of large numbers of samples via pooling
P DANAHER, CC VALENTINE III
US Patent App. 17/285,846, 2022
12022
Duplex Sequencing for Ultra-Low Frequency Measurable Residual Disease Detection in Adult Acute Myeloid Leukemia
J Higgins, M Othus, LW Dillon, TH Smith, E Schmidt, J Yaplee, FY Lo, ...
Blood 138, 3475, 2021
12021
Adopting Duplex Sequencing. Technology for Genetic Toxicity Testing: A Proof-of-Concept Mutagenesis Experiment with N-Ethyl-N-Nitrosourea (ENU)-Exposed Rats.
SL Smith-Roe, CA Hobbs, L Recio, MA Streicker, M Rivas, GA Pratt, ...
Environmental and Molecular Mutagenesis 61, 63-63, 2020
12020
Redefining “Gold Standard”: Ultra-Sensitive Characterization of Commercial DNA Standards with Duplex Sequencing
J Higgins, G Pratt, CC Valentine, LN Williams, JJ Salk
Blood 134, 2093, 2019
12019
Ultra-accurate assessment of pretreatment ABL1 kinase domain (KD) mutations in patients (pts) with newly diagnosed Philadelphia chromosome-positive acute lymphoblastic leukemia …
NJ Short, HM Kantarjian, R Kanagal-Shamanna, K Sasaki, F Ravandi, ...
Blood 134, 2578, 2019
12019
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