Deborah M. Muoio
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Mitochondrial overload and incomplete fatty acid oxidation contribute to skeletal muscle insulin resistance
TR Koves, JR Ussher, RC Noland, D Slentz, M Mosedale, O Ilkayeva, ...
Cell metabolism 7 (1), 45-56, 2008
Molecular and metabolic mechanisms of insulin resistance and β-cell failure in type 2 diabetes
DM Muoio, CB Newgard
Nature reviews Molecular cell biology 9 (3), 193-205, 2008
Energy metabolism in uncoupling protein 3 gene knockout mice
AJ Vidal-Puig, D Grujic, CY Zhang, T Hagen, O Boss, Y Ido, A Szczepanik, ...
Journal of Biological Chemistry 275 (21), 16258-16266, 2000
Leptin directly alters lipid partitioning in skeletal muscle
DM Muoio, GL Dohn, FT Fiedorek Jr, EB Tapscott, RA Coleman
Diabetes 46 (8), 1360-1363, 1997
Genome-wide chromatin state transitions associated with developmental and environmental cues
J Zhu, M Adli, JY Zou, G Verstappen, M Coyne, X Zhang, T Durham, ...
Cell 152 (3), 642-654, 2013
Peroxisome proliferator-activated receptor-γ co-activator 1α-mediated metabolic remodeling of skeletal myocytes mimics exercise training and reverses lipid-induced …
TR Koves, P Li, J An, T Akimoto, D Slentz, O Ilkayeva, GL Dohm, Z Yan, ...
Journal of Biological Chemistry 280 (39), 33588-33598, 2005
AMP-activated kinase reciprocally regulates triacylglycerol synthesis and fatty acid oxidation in liver and muscle: evidence that sn-glycerol-3-phosphate acyltransferase is a …
DM Muoio, K Seefeld, LA Witters, RA Coleman
Biochemical Journal 338 (3), 783-791, 1999
Hepatic expression of malonyl-CoA decarboxylase reverses muscle, liver and whole-animal insulin resistance
J An, DM Muoio, M Shiota, Y Fujimoto, GW Cline, GI Shulman, TR Koves, ...
Nature medicine 10 (3), 268-274, 2004
Fatty acid homeostasis and induction of lipid regulatory genes in skeletal muscles of peroxisome proliferator-activated receptor (PPAR) α knock-out mice: evidence for …
DM Muoio, PS MacLean, DB Lang, S Li, JA Houmard, JM Way, ...
Journal of Biological Chemistry 277 (29), 26089-26097, 2002
The failing heart relies on ketone bodies as a fuel
G Aubert, OJ Martin, JL Horton, L Lai, RB Vega, TC Leone, T Koves, ...
Circulation 133 (8), 698-705, 2016
Obesity-related derangements in metabolic regulation
DM Muoio, CB Newgard
Annu. Rev. Biochem. 75, 367-401, 2006
Elevated stearoyl-CoA desaturase-1 expression in skeletal muscle contributes to abnormal fatty acid partitioning in obese humans
MW Hulver, JR Berggren, MJ Carper, M Miyazaki, JM Ntambi, EP Hoffman, ...
Cell metabolism 2 (4), 251-261, 2005
Physiological and nutritional regulation of enzymes of triacylglycerol synthesis
RA Coleman, TM Lewin, DM Muoio
Annual review of nutrition 20, 77, 2000
Carnitine insufficiency caused by aging and overnutrition compromises mitochondrial performance and metabolic control
RC Noland, TR Koves, SE Seiler, H Lum, RM Lust, O Ilkayeva, ...
Journal of biological chemistry 284 (34), 22840-22852, 2009
Inhibition of de novo ceramide synthesis reverses diet-induced insulin resistance and enhances whole-body oxygen consumption
JR Ussher, TR Koves, VJJ Cadete, L Zhang, JS Jaswal, SJ Swyrd, ...
Diabetes 59 (10), 2453-2464, 2010
Metabolomics applied to diabetes research: moving from information to knowledge
JR Bain, RD Stevens, BR Wenner, O Ilkayeva, DM Muoio, CB Newgard
Diabetes 58 (11), 2429-2443, 2009
Understanding the cellular and molecular mechanisms of physical activity-induced health benefits
PD Neufer, MM Bamman, DM Muoio, C Bouchard, DM Cooper, ...
Cell metabolism 22 (1), 4-11, 2015
Lipid-induced mitochondrial stress and insulin action in muscle
DM Muoio, PD Neufer
Cell metabolism 15 (5), 595-605, 2012
Muscle-specific deletion of carnitine acetyltransferase compromises glucose tolerance and metabolic flexibility
DM Muoio, RC Noland, JP Kovalik, SE Seiler, MN Davies, KL DeBalsi, ...
Cell metabolism 15 (5), 764-777, 2012
SIRT4 coordinates the balance between lipid synthesis and catabolism by repressing malonyl CoA decarboxylase
G Laurent, NJ German, AK Saha, VCJ de Boer, M Davies, TR Koves, ...
Molecular cell 50 (5), 686-698, 2013
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