|Mitochondrial overload and incomplete fatty acid oxidation contribute to skeletal muscle insulin resistance|
TR Koves, JR Ussher, RC Noland, D Slentz, M Mosedale, O Ilkayeva, ...
Cell metabolism 7 (1), 45-56, 2008
|Molecular and metabolic mechanisms of insulin resistance and β-cell failure in type 2 diabetes|
DM Muoio, CB Newgard
Nature reviews Molecular cell biology 9 (3), 193-205, 2008
|Energy metabolism in uncoupling protein 3 gene knockout mice|
AJ Vidal-Puig, D Grujic, CY Zhang, T Hagen, O Boss, Y Ido, A Szczepanik, ...
Journal of Biological Chemistry 275 (21), 16258-16266, 2000
|Leptin directly alters lipid partitioning in skeletal muscle|
DM Muoio, GL Dohn, FT Fiedorek Jr, EB Tapscott, RA Coleman
Diabetes 46 (8), 1360-1363, 1997
|Genome-wide chromatin state transitions associated with developmental and environmental cues|
J Zhu, M Adli, JY Zou, G Verstappen, M Coyne, X Zhang, T Durham, ...
Cell 152 (3), 642-654, 2013
|Peroxisome proliferator-activated receptor-γ co-activator 1α-mediated metabolic remodeling of skeletal myocytes mimics exercise training and reverses lipid-induced …|
TR Koves, P Li, J An, T Akimoto, D Slentz, O Ilkayeva, GL Dohm, Z Yan, ...
Journal of Biological Chemistry 280 (39), 33588-33598, 2005
|AMP-activated kinase reciprocally regulates triacylglycerol synthesis and fatty acid oxidation in liver and muscle: evidence that sn-glycerol-3-phosphate acyltransferase is a …|
DM Muoio, K Seefeld, LA Witters, RA Coleman
Biochemical Journal 338 (3), 783-791, 1999
|Hepatic expression of malonyl-CoA decarboxylase reverses muscle, liver and whole-animal insulin resistance|
J An, DM Muoio, M Shiota, Y Fujimoto, GW Cline, GI Shulman, TR Koves, ...
Nature medicine 10 (3), 268-274, 2004
|Fatty acid homeostasis and induction of lipid regulatory genes in skeletal muscles of peroxisome proliferator-activated receptor (PPAR) α knock-out mice: evidence for …|
DM Muoio, PS MacLean, DB Lang, S Li, JA Houmard, JM Way, ...
Journal of Biological Chemistry 277 (29), 26089-26097, 2002
|The failing heart relies on ketone bodies as a fuel|
G Aubert, OJ Martin, JL Horton, L Lai, RB Vega, TC Leone, T Koves, ...
Circulation 133 (8), 698-705, 2016
|Obesity-related derangements in metabolic regulation|
DM Muoio, CB Newgard
Annu. Rev. Biochem. 75, 367-401, 2006
|Elevated stearoyl-CoA desaturase-1 expression in skeletal muscle contributes to abnormal fatty acid partitioning in obese humans|
MW Hulver, JR Berggren, MJ Carper, M Miyazaki, JM Ntambi, EP Hoffman, ...
Cell metabolism 2 (4), 251-261, 2005
|Physiological and nutritional regulation of enzymes of triacylglycerol synthesis|
RA Coleman, TM Lewin, DM Muoio
Annual review of nutrition 20, 77, 2000
|Carnitine insufficiency caused by aging and overnutrition compromises mitochondrial performance and metabolic control|
RC Noland, TR Koves, SE Seiler, H Lum, RM Lust, O Ilkayeva, ...
Journal of biological chemistry 284 (34), 22840-22852, 2009
|Inhibition of de novo ceramide synthesis reverses diet-induced insulin resistance and enhances whole-body oxygen consumption|
JR Ussher, TR Koves, VJJ Cadete, L Zhang, JS Jaswal, SJ Swyrd, ...
Diabetes 59 (10), 2453-2464, 2010
|Metabolomics applied to diabetes research: moving from information to knowledge|
JR Bain, RD Stevens, BR Wenner, O Ilkayeva, DM Muoio, CB Newgard
Diabetes 58 (11), 2429-2443, 2009
|Understanding the cellular and molecular mechanisms of physical activity-induced health benefits|
PD Neufer, MM Bamman, DM Muoio, C Bouchard, DM Cooper, ...
Cell metabolism 22 (1), 4-11, 2015
|Lipid-induced mitochondrial stress and insulin action in muscle|
DM Muoio, PD Neufer
Cell metabolism 15 (5), 595-605, 2012
|Muscle-specific deletion of carnitine acetyltransferase compromises glucose tolerance and metabolic flexibility|
DM Muoio, RC Noland, JP Kovalik, SE Seiler, MN Davies, KL DeBalsi, ...
Cell metabolism 15 (5), 764-777, 2012
|SIRT4 coordinates the balance between lipid synthesis and catabolism by repressing malonyl CoA decarboxylase|
G Laurent, NJ German, AK Saha, VCJ de Boer, M Davies, TR Koves, ...
Molecular cell 50 (5), 686-698, 2013