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Aidan CA Tomlinson
Aidan CA Tomlinson
Scientist I, RevMed
Verified email at revmed.com
Title
Cited by
Cited by
Year
The human coronavirus HCoV-229E S-protein structure and receptor binding
Z Li, ACA Tomlinson, AHM Wong, D Zhou, M Desforges, PJ Talbot, ...
Elife 8, e51230, 2019
2062019
Receptor-binding loops in alphacoronavirus adaptation and evolution
AHM Wong, ACA Tomlinson, D Zhou, M Satkunarajah, K Chen, C Sharon, ...
Nature communications 8 (1), 1735, 2017
932017
Chemical remodeling of a cellular chaperone to target the active state of mutant KRAS
CJ Schulze, KJ Seamon, Y Zhao, YC Yang, J Cregg, D Kim, A Tomlinson, ...
Science 381 (6659), 794-799, 2023
412023
Discovery of RMC-5552, a selective bi-steric inhibitor of mTORC1, for the treatment of mTORC1-activated tumors
GL Burnett, YC Yang, JB Aggen, J Pitzen, MK Gliedt, CM Semko, ...
Journal of medicinal chemistry 66 (1), 149-169, 2022
232022
Concurrent inhibition of oncogenic and wild-type RAS-GTP for cancer therapy
M Holderfield, BJ Lee, J Jiang, A Tomlinson, KJ Seamon, A Mira, ...
Nature, 1-8, 2024
102024
A first-in-class tri-complex KRASG13C(ON) inhibitor validates therapeutic targeting of KRASG13Cand drives tumor regressions in preclinical models
CJ Schulze, J Cregg, KJ Seamon, YC Yang, Z Wang, LS Garrenton, ...
Cancer Research 82 (12_Supplement), 3598-3598, 2022
52022
Translational and therapeutic evaluation of RAS-GTP inhibition by RMC-6236 in RAS-driven cancers
J Jiang, L Jiang, BJ Maldonato, Y Wang, M Holderfield, I Aronchik, ...
Cancer Discovery 14 (6), 994-1017, 2024
42024
Concurrent inhibition of oncogenic and wild-type RAS-GTP for cancer therapy
M Singh, M Holderfield, B Lee, J Jiang, A Tomlinson, K Seamon, A Mira, ...
42023
Abstract ND07: Discovery of RMC-6291, a tri-complex KRASG12C(ON) inhibitor
J Cregg, RJ Nichols, YC Yang, CJ Schulze, Z Wang, R Dua, J Jiang, ...
Cancer Research 83 (7_Supplement), ND07-ND07, 2023
22023
RM-046, a first-in-class, mutant-selective, and oral KRASQ61H(ON) inhibitor that drives tumor regression in preclinical models and validates KRASQ61H as a …
YC Yang, S Thompson, D Montgomery, AJ Quiñones, X Wei, B Madej, ...
Cancer Research 83 (7_Supplement), 1598-1598, 2023
12023
Abstract B137: Selective inhibition of the active state of KRASG12V with the non-covalent, tri-complex inhibitor RM-048
BJ Lee, J Cregg, A Edwards, J Chen, A Eriksson, E Tonogai, A Tomlinson, ...
Molecular Cancer Therapeutics 22 (12_Supplement), B137-B137, 2023
2023
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