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Chemical remodeling of a cellular chaperone to target the active state of mutant KRAS CJ Schulze, KJ Seamon, Y Zhao, YC Yang, J Cregg, D Kim, A Tomlinson, ... Science 381 (6659), 794-799, 2023 | 41 | 2023 |
Discovery of RMC-5552, a selective bi-steric inhibitor of mTORC1, for the treatment of mTORC1-activated tumors GL Burnett, YC Yang, JB Aggen, J Pitzen, MK Gliedt, CM Semko, ... Journal of medicinal chemistry 66 (1), 149-169, 2022 | 23 | 2022 |
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A first-in-class tri-complex KRASG13C(ON) inhibitor validates therapeutic targeting of KRASG13Cand drives tumor regressions in preclinical models CJ Schulze, J Cregg, KJ Seamon, YC Yang, Z Wang, LS Garrenton, ... Cancer Research 82 (12_Supplement), 3598-3598, 2022 | 5 | 2022 |
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