Manfred Jung

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Wolfgang SipplProfessor of Medicinal ChemistryVerified email at pharmazie.uni-halle.de
Martin MarekResearch Scientist & Team Leader, Loschmidt Laboratories, Masaryk UniversityVerified email at recetox.muni.cz
Eric VerdinCEO & President, Buck Institute for Research on AgingVerified email at buckinstitute.org
Attila LehotzkyInstitute of Enzymology, Research Centre of Natural SciencesVerified email at ttk.hu
Guilherme OliveiraInstituto Tecnológico ValeVerified email at itv.org
Lucia Altucci, MD, PhDSeconda Università di NapoliVerified email at unina2.it
Stefan GüntherProfessor for Pharmaceutical Bioinformatics, Freiburg UniversityVerified email at pharmazie.uni-freiburg.de
Bernhard BreitAlbert-Ludwigs-Universität FreiburgVerified email at chemie.uni-freiburg.de
Brian J. NorthCreighton University School of MedicineVerified email at creighton.edu
Antonello MaiProfessore di Chimica Farmaceutica, Sapienza Università di RomaVerified email at uniroma1.it
David ChristiansonProfessor of Chemistry, University of PennsylvaniaVerified email at sas.upenn.edu
Melanie OttVerified email at gladstone.ucsf.edu
Clarissa GerhauserGroup Leader, German Cancer Research Center (dkfz.) HeidelbergVerified email at dkfz.de
Xavier LucasSenior scientist in computational drug design at Monte Rosa Therapeutics, BaselVerified email at monterosatx.com
Matthias KassackProfessorVerified email at uni-duesseldorf.de
Martin PippelBioinformatician, NBIS - National Bioinformatics Infrastructure SwedenVerified email at nbis.se
Dante Rotili, PhDProfessor of Medicinal Chemistry, "Sapienza" University of RomeVerified email at uniroma1.it
Suhaib ShekfehMartin-Luther-University Medicinal ChemistryVerified email at pharmazie.uni-hale.de
Huanbiao MoProfessor of Nutrition, Georgia State UniversityVerified email at gsu.edu
David A. SinclairHarvard Medical School (Genetics)Verified email at hms.harvard.edu

Manfred Jung

Institute of Pharmaceutical Sciences, University of Freiburg; former University of Münster, Ottawa

Verified email at pharmazie.uni-freiburg.de - Homepage

Medicinal Chemistry Chemical Biology: Chemical Epigenetics Histone acetyltransferases deacetylases methyltransferases


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Histone deacetylase (HDAC) inhibitors in recent clinical trials for cancer therapy JM Wagner, B Hackanson, M Lübbert, M Jung Clinical epigenetics 1 (3), 117-136, 2010	445	2010
SIRT1 regulates HIV transcription via Tat deacetylation S Pagans, A Pedal, BJ North, K Kaehlcke, BL Marshall, A Dorr, ... PLoS biology 3 (2), e41, 2005	395	2005
Targeting histone methyltransferases and demethylases in clinical trials for cancer therapy L Morera, M Lübbert, M Jung Clinical epigenetics 8, 1-16, 2016	378	2016
Inhibitors of histone deacetylase as new anticancer agents M Jung Current medicinal chemistry 8 (12), 1505-1511, 2001	284	2001
Amide analogues of trichostatin A as inhibitors of histone deacetylase and inducers of terminal cell differentiation M Jung, G Brosch, D Kölle, H Scherf, C Gerhäuser, P Loidl Journal of medicinal chemistry 42 (22), 4669-4679, 1999	259	1999
Chemically induced degradation of sirtuin 2 (Sirt2) by a proteolysis targeting chimera (PROTAC) based on sirtuin rearranging ligands (SirReals) M Schiedel, D Herp, S Hammelmann, S Swyter, A Lehotzky, D Robaa, ... Journal of medicinal chemistry 61 (2), 482-491, 2018	236	2018
Selective Sirt2 inhibition by ligand-induced rearrangement of the active site T Rumpf, M Schiedel, B Karaman, C Roessler, BJ North, A Lehotzky, ... Nature communications 6 (1), 6263, 2015	233	2015
HDAC8: a multifaceted target for therapeutic interventions A Chakrabarti, I Oehme, O Witt, G Oliveira, W Sippl, C Romier, RJ Pierce, ... Trends in pharmacological sciences 36 (7), 481-492, 2015	228	2015
Structure–Activity Studies on Suramin Analogues as Inhibitors of NAD⁺‐Dependent Histone Deacetylases (Sirtuins) J Trapp, R Meier, D Hongwiset, MU Kassack, W Sippl, M Jung ChemMedChem: Chemistry Enabling Drug Discovery 2 (10), 1419-1431, 2007	220	2007
Adenosine mimetics as inhibitors of NAD+-dependent histone deacetylases, from kinase to sirtuin inhibition J Trapp, A Jochum, R Meier, L Saunders, B Marshall, C Kunick, E Verdin, ... Journal of medicinal chemistry 49 (25), 7307-7316, 2006	190	2006
The emerging therapeutic potential of histone methyltransferase and demethylase inhibitors A Spannhoff, AT Hauser, R Heinke, W Sippl, M Jung ChemMedChem: Chemistry Enabling Drug Discovery 4 (10), 1568-1582, 2009	187	2009
Structure–activity studies on splitomicin derivatives as sirtuin inhibitors and computational prediction of binding mode RC Neugebauer, U Uchiechowska, R Meier, H Hruby, V Valkov, E Verdin, ... Journal of medicinal chemistry 51 (5), 1203-1213, 2008	186	2008
Structural Basis for the Inhibition of Histone Deacetylase 8 (HDAC8), a Key Epigenetic Player in the Blood Fluke Schistosoma mansoni M Marek, S Kannan, AT Hauser, M Moraes Mourão, S Caby, V Cura, ... PLoS pathogens 9 (9), e1003645, 2013	184	2013
Enhancement of radiation sensitivity of human squamous carcinoma cells by histone deacetylase inhibitors Y Zhang, M Jung, A Dritschilo, M Jung Radiation research 161 (6), 667-674, 2004	171	2004
Inhibitors of human histone deacetylase: synthesis and enzyme and cellular activity of straight chain hydroxamates SW Remiszewski, LC Sambucetti, P Atadja, KW Bair, WD Cornell, ... Journal of medicinal chemistry 45 (4), 753-757, 2002	165	2002
Target-based approach to inhibitors of histone arginine methyltransferases A Spannhoff, R Heinke, I Bauer, P Trojer, E Metzger, R Gust, R Schüle, ... Journal of medicinal chemistry 50 (10), 2319-2325, 2007	159	2007
Subtype selective substrates for histone deacetylases B Heltweg, F Dequiedt, BL Marshall, C Brauch, M Yoshida, N Nishino, ... Journal of medicinal chemistry 47 (21), 5235-5243, 2004	150	2004
Impairment of prostate cancer cell growth by a selective and reversible LSD1 inhibitor D Willmann, S Lim, S Wetzel, E Metzger, A Jandausch, W Wilk, M Jung, ... International Journal of Cancer 128, 574-586, 2012	145*	2012
In vitro assays for the determination of histone deacetylase activity B Heltweg, J Trapp, M Jung Methods 36 (4), 332-337, 2005	144	2005
Characterization of novel inhibitors of histone acetyltransferases ED Eliseeva, V Valkov, M Jung, MO Jung Molecular cancer therapeutics 6 (9), 2391-2398, 2007	141	2007

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