| The allosteric vestibule of a seven transmembrane helical receptor controls G-protein coupling A Bock, N Merten, R Schrage, C Dallanoce, J Bätz, J Klöckner, J Schmitz, ... Nature communications 3 (1), 1044, 2012 | 155 | 2012 |
| Optical mapping of cAMP signaling at the nanometer scale A Bock, P Annibale, C Konrad, A Hannawacker, SE Anton, I Maiellaro, ... Cell 182 (6), 1519-1530. e17, 2020 | 138 | 2020 |
| Single-molecule analysis reveals agonist-specific dimer formation of µ-opioid receptors J Möller, A Isbilir, T Sungkaworn, B Osberg, C Karathanasis, V Sunkara, ... Nature Chemical Biology 16 (9), 946-954, 2020 | 104 | 2020 |
| Receptor-associated independent cAMP nanodomains mediate spatiotemporal specificity of GPCR signaling SE Anton, C Kayser, I Maiellaro, K Nemec, J Möller, A Koschinski, ... Cell 185 (7), 1130-1142. e11, 2022 | 95 | 2022 |
| A biased ligand for OXE-R uncouples Gα and Gβγ signaling within a heterotrimer S Blättermann, L Peters, PA Ottersbach, A Bock, V Konya, CD Weaver, ... Nature chemical biology 8 (7), 631-638, 2012 | 95 | 2012 |
| Ligand binding ensembles determine graded agonist efficacies at a G protein-coupled receptor A Bock, M Bermudez, F Krebs, C Matera, B Chirinda, D Sydow, ... Journal of Biological Chemistry 291 (31), 16375-16389, 2016 | 80 | 2016 |
| Allosteric modulators targeting CNS muscarinic receptors A Bock, R Schrage, K Mohr Neuropharmacology 136, 427-437, 2018 | 75 | 2018 |
| Dynamic ligand binding dictates partial agonism at a G protein–coupled receptor A Bock, B Chirinda, F Krebs, R Messerer, J Bätz, M Muth, C Dallanoce, ... Nature chemical biology 10 (1), 18-20, 2014 | 65 | 2014 |
| Stepwise activation of a class C GPCR begins with millisecond dimer rearrangement EO Grushevskyi, T Kukaj, R Schmauder, A Bock, U Zabel, T Schwabe, ... Proceedings of the National Academy of Sciences 116 (20), 10150-10155, 2019 | 60 | 2019 |
| Experimental and mathematical analysis of cAMP nanodomains C Lohse, A Bock, I Maiellaro, A Hannawacker, LR Schad, MJ Lohse, ... PLoS One 12 (4), e0174856, 2017 | 52 | 2017 |
| Rational Design of Partial Agonists for the Muscarinic M1 Acetylcholine Receptor X Chen, J Klöckner, J Holze, C Zimmermann, WK Seemann, R Schrage, ... Journal of medicinal chemistry 58 (2), 560-576, 2015 | 45 | 2015 |
| Allosteric coupling and biased agonism in G protein‐coupled receptors A Bock, M Bermudez The FEBS Journal 288 (8), 2513-2528, 2021 | 40 | 2021 |
| Pilot the pulse: controlling the multiplicity of receptor dynamics A Bock, E Kostenis, C Tränkle, MJ Lohse, K Mohr Trends in pharmacological sciences 35 (12), 630-638, 2014 | 37 | 2014 |
| Quantitative single-residue bioorthogonal labeling of G protein-coupled receptors in live cells R Serfling, L Seidel, A Bock, MJ Lohse, P Annibale, I Coin ACS chemical biology 14 (6), 1141-1149, 2019 | 35 | 2019 |
| Ligand-Specific Restriction of Extracellular Conformational Dynamics Constrains Signaling of the M2 Muscarinic Receptor M Bermudez, A Bock, F Krebs, U Holzgrabe, K Mohr, MJ Lohse, G Wolber ACS chemical biology 12 (7), 1743-1748, 2017 | 27 | 2017 |
| Dualsteric GPCR targeting and functional selectivity: the paradigmatic M2 muscarinic acetylcholine receptor A Bock, K Mohr Drug Discovery Today: Technologies 10 (2), e245-e252, 2013 | 25 | 2013 |
| Determination of G-protein–coupled receptor oligomerization by molecular brightness analyses in single cells A Işbilir, R Serfling, J Möller, R Thomas, C De Faveri, U Zabel, M Scarselli, ... Nature Protocols 16 (3), 1419-1451, 2021 | 24 | 2021 |
| Does divergent binding pocket closure drive ligand bias for class A GPCRs? M Bermudez, A Bock Trends in pharmacological sciences 40 (4), 236-239, 2019 | 23 | 2019 |
| Ligand-specific allosteric coupling controls G-protein-coupled receptor signaling J Holze, M Bermudez, EM Pfeil, M Kauk, T Bödefeld, M Irmen, C Matera, ... ACS pharmacology & translational science 3 (5), 859-867, 2020 | 20 | 2020 |
| A New Molecular Mechanism To Engineer Protean Agonism at a G Protein–Coupled Receptor A De Min, C Matera, A Bock, J Holze, J Kloeckner, M Muth, C Traenkle, ... Molecular pharmacology 91 (4), 348-356, 2017 | 16 | 2017 |
